Distribution of the Total CCC Score (N = 7942).

<p>Distribution of the Total CCC Score (N = 7942).</p

Final model of 19 variables derived from the 77 independently associated variables from domain specific models by linear and ordinal regression (N = 7613).

<p>Variables are ranked by their partial correlation in linear regression. This is almost equivalent to ranking by effect size. Variables have been standardised to have a variance of 1. All p values in ordinal regression <0.0036 with 12 variables p< FDR criterion. The explanations of the log likelihood by the linear and ordinal models were 13.34% and 2.39% respectively. B>0 and ORs >1 are beneficial effects.</p><p>^a Part of Fragile inner self subscale at 18w</p><p>^b Part of EPDS at 32w</p><p>^c Part of maternal locus of control at 12w</p><p>^d As reported by the partner at 18w</p><p>^f p value > FDR criterion</p><p>Final model of 19 variables derived from the 77 independently associated variables from domain specific models by linear and ordinal regression (N = 7613).</p

Interaction effects on the Total CCC score (N = 7613).

<p>The figure shows four interactions: two with <i>Often unfairly blamed</i> (A) and two with <i>Processed dietary factor</i> (B and C). The significance of the interactions were p = 0.000019 and 0.000022 (A), p = 0.000071 (B) and p = 0.000048 (C).</p

Selection of variables in the analysis of the total CCC score.

<p>Selection of variables in the analysis of the total CCC score.</p

Q-Q plot of the p values from the analysis of all 3855 variables.

<p>The False Discovery Rate (FDR) method for multiple comparisons utilises a variable criterion ranging from the nominal significance level for the highest p value to the equivalent Bonferroni critical value for the lowest p value. The specific FDR criterion for a particular set of results is determined where this line intersects the observed p values. For these results, the FDR critical value was 0.0001572.</p

Additional file 1: of Autism diagnosis differentiates neurophysiological responses to faces in adults with tuberous sclerosis complex

Supplementary data. Group differences between TSC-only and TSC + ASD with IQ as a covariate

Additional file 2: Tables S1–S3. of Autism diagnosis differentiates neurophysiological responses to faces in adults with tuberous sclerosis complex

Table S1: Mean (SD) number of segments in each ERP average per stimulus and group during the face and gaze processing task. Table S2: Mean (SD) amplitude (in μV) and latency (in ms) for the P1 for each stimulus by group. Table S3: Mean amplitude (in μV) and latency (in ms) for the N170 for each stimulus by group

Additional file 2: of Attention training for infants at familial risk of ADHD (INTERSTAARS): study protocol for a randomised controlled trial

SPIRIT Checklist [44]. (PDF 106 kb

Additional file 1: Table S1. of Attention training for infants at familial risk of ADHD (INTERSTAARS): study protocol for a randomised controlled trial

Summary of measures. (PDF 99 kb

Genetic alterations identified in the control subject SWE_Q56_508.

<p>A. <i>SHANK2</i> splice mutation (IVS22+1G>T) detected in a Swedish female control, SWE_Q56_508. The mutation altered the donor splicing site of exon 22 and led to a premature stop in all <i>SHANK2</i> isoforms except for the <i>AF1411901</i> isoform, where it altered the protein sequence (G263V). B. CNVs in the same individual altering <i>LOC339822</i>, <i>SNTG2</i>, <i>PXDN</i> and <i>MYT1L</i>. The two close duplications span 264 kb and 245 kb on chromosome 2 and altered <i>LOC339822</i> and <i>SNTG2</i>, and <i>PXDN</i> and <i>MYT1L</i>, respectively. Dots show the B allele frequency (BAF; in green), Log R ratio (LRR; in red), and QuantiSNP score (in blue). Lower panel: all CNVs listed in the Database of Genomic Variants (DGV) are represented: loss (in red), gain (in blue), gain or loss (in brown). H, homer binding site; D, dynamin binding site; C, cortactin binding site.</p