1 research outputs found
Dynamic Light Scattering Investigation of the Kinetics and Fidelity of Supramolecular Copolymerizations in Water
The self-assembly
of supramolecular copolymers facilitates the
preparation of multifunctional materials, with tunable mechanical,
electronic, or bioactive properties. Compared to covalent copolymerization
protocols, controlling the molecular weight, stability, and monomer
sequence of a multicomponent supramolecular copolymer remains limited.
Here, we report a light scattering investigation of the charge-regulated
supramolecular copolymerization in neutral buffer of physiological
ionic strength, supported with electron microscopy and circular dichroism
spectroscopy experiments. Dendritic anionic and cationic peptide comonomers
self-assemble into AB-type heterocopolymers with a nanorod-like morphology,
a thickness of 11 nm, and a mean length of up to 70 nm. The fidelity
in the copolymerization is remarkably high, and excess of either monomer
of up to 50 mol % in the feed ratio does not lead to chain stoppering.
The narrow length distribution of the copolymers (<i>Đ</i> < 1.3) and high colloidal stability in physiological buffer support
their applications as biomedical carrier materials