Sialolipoma na glândula salivar sublingual em cão – primeiro relato

This report describes a 14-year-old Pit Bull dog presenting with a soft tissue swelling of 3-month progression in the right sublingual region. Histopathological analysis of the surgically resected specimen revealed large numbers of mature adipocytes and islets consisting of mucin-containing atrophic acini and dilated ducts surrounded by a thin fibrous capsule. Findings were consistent with sialolipoma of the sublingual salivary gland. To the authors’ knowledge, this is the first case of sialolipoma affecting the sublingual salivary gland in dogs.O presente relato descreve um cão Pit Bull, de 14 anos, com aumento de volume de consistência macia em região sublingual direita com evolução de 3 meses. Após excisão cirúrgica, a análise histopatológica revelou grande número de adipócitos maduros, tecido glandular composto por ductos dilatados e ácinos atróficos contendo mucina, circundados por fina cápsula fibrosa, achados compatíveis com sialolipoma da glândula salivar sublingual. Pelo conhecimento dos autores, este é o primeiro relato de sialolipoma acometendo glândula salivar sublingual em cão

A closer look at the health of cats showing urinary house-soiling (periuria): a case-control study

Objective The aim was to perform a case-control medical evaluation of cats from multi-cat households presenting with inappropriate latrining and spraying behavior. Methods Owners of 18 ‘spraying’ and 23 ‘latrining’ cats with normal control subjects available from the same households were recruited for a case-control study. Otherwise overtly healthy dyads (each dyad consisting of a case cat and a control cat) were brought together to the veterinary hospital of the University of São Paulo for a medical work-up (ie, physical examination, complete blood count, biochemical profile, urinalysis and urine culture, abdominal ultrasound of the urinary system and in females, where possible, cystoscopy). Results Medical problems were identified with similar frequency in the ‘sprayers’ (38.9%), ‘latriners’ (39.1%) and controls of the latrining group (26.1%), but not the controls of the spraying group (5.5%). The difference between ‘cases’ and ‘controls’ from spraying households was significant. Common potential health-related changes include renal insufficiency, cystitis and bladder lithiasis. Renal calculi, higher creatinine levels (within normal reference interval) and ‘glomerulations’ (detected during cystoscopy) were also found in the remaining sprayers and latriners that were considered clinically healthy. Post-cystoscopy, a new form of periuria occurred in two cats (one sprayer and one latriner). Conclusions and relevance These results indicate that spraying or latrining behavior in the home, as well as living with a cat that is not using the litter box as a latrine, are all associated with a higher level of urinary tract abnormalities, but not living with a cat that is spraying. The findings also suggest that both forms of periuria might be associated with interstitial cystitis. We therefore conclude that all cats with periuria need to be carefully evaluated medically and that treatment of latrine-related problems should consider all cats in the house, whereas spraying may be more focused on the individual displaying the problem

Local tumour response to neoadjuvant therapy with 2‐aminoethyl dihydrogen phosphate in dogs with soft tissue sarcoma

Abstract Background In cases of soft tissue sarcoma (STS), neoadjuvant therapy is indicated to downstage the tumour prior to surgery to achieve enhanced local tumour control. The antineoplastic phospholipid compound 2‐aminoethyl dihydrogen phosphate (2‐AEH2F) is an alkyl phosphate ester capable of inhibiting cell proliferation and inducing cell death by modifying the asymmetry of phospholipids in the cytoplasmic membrane Objectives This clinical study was designed to investigate local antitumoural effects of neoadjuvant therapy with 2‐AEH2F in dogs with naturally occurring STS Material and methods Dogs (n = 11) received four consecutive weekly intravenous injections of 2‐AEH2F (70 mg/kg) prior to tumour resection. Tomographic (CT) and thermal (TE) images were used to investigate changes in tumour size and local temperature in response to treatment Results Comparative analysis of CT images (n = 9/11) failed to reveal complete or partial remission according to selected assessment criteria (RECIST, WHO and volumetric). Comparative analysis of TE images (n = 10/11) revealed significantly (p = 0.01416) lower temperatures in tumoural areas relative to surrounding tissues over the course of treatment Conclusions 2‐AEH2F had no cytoreductive effects when used at doses and intervals described in this study. However, significant drop in skin temperatures recorded in tumoural areas suggest induction of physiological changes

Early parenteral nutrition in enterectomized dogs

ABSTRACT: The aim of this study was to explore the role of early central parenteral nutrition support with and without lipid emulsion in enterectomized dogs undergoing small bowel partial resection. Enterectomized dogs often cannot be fed properly via an oral or enteral route immediately post-surgery. After enterectomy, the animals received parenteral nutrition or crystalloid solution until they were able to voluntarily take in an oral diet. All dogs were recruited at the University of Sao Paulo veterinary teaching hospital. Eighteen dogs with intussusception, a foreign intestinal body, linear foreign intestinal body, or intussusception associated with a foreign intestinal body underwent enterectomy surgery and were randomly assigned to receive one of three treatments: crystalloid solution (CS group), parenteral nutrition with a mix of glucose and amino acids (GA group) or parenteral nutrition with a mix of glucose, amino acids and lipids (GAL group). A serum chemistry panel and complete blood count were collected prior to surgery and at the end of the study. Albumin increased in the GA and GAL group (p=0.042 and p=0.038 respectively) after hospitalization, but no significant differences were identified among the groups. Body weight decreased by 4.9% (p=0.042) in the CS group, but there were no significant changes in the GAL and GA groups. There was a significant decrease in the recovery scores in the GA and GAL groups during hospitalization (p=0.039 in both groups). Early parenteral nutrition was beneficial for patient recovery in post-surgical small bowel partial resection, indicating better quality, and no major complications or side effects were observed during the hospitalization period in the studied dogs

Postoperative pain and short-term complications after two elective sterilization techniques: ovariohysterectomy or ovariectomy in cats

Abstract Background Surgical sterilization of cats is one of the most commonly performed procedures in veterinary practice and it can be accomplished by two different techniques: ovariohysterectomy (OVH) or ovariectomy (OVE). Although there is an apparent preference for OVH in United States and Canada, OVE seems to be the standard of care in many European countries due to its advantages, such as a smaller surgical incision and potentially less complications associated with surgical manipulation of the uterus. The aim of this randomized, blind, prospective study was to compare postoperative pain and short-term complications in cats undergoing ovariohysterectomy or ovariectomy. Methods Twenty female cats were randomly assigned into two groups (OVH, n = 10 and OVE, n = 10). Pain was assessed prior to surgery (baseline) and 1, 2, 4, 8 12 and 24 h after the procedure using pain and sedation scales, physiologic parameters and blood glucose levels. Short-term complications were evaluated in the early postoperative period and reassessed at day 7 and day 10. Results Changes in cardiovascular parameters were not clinically relevant, however cats in OVH group had higher heart rates at T1 h compared with baseline (p = 0.0184). Blood glucose levels in OVH group were also higher at T1 h compared with baseline (p = 0.0135) and with OVE group (p = 0.0218). Surgical time was higher in OVH group (p = 0.0115). Even though no significant differences in pain scores were observed between groups or time points, cats in OVH group had greater need for rescue analgesia compared with OVE (2/10 and 0/10, respectively). Complications were not observed in any cat during surgery, at days 7 and 10 postoperatively or at discharge. Conclusions Both surgical techniques promoted similar intensity of postoperative pain in cats and there were no short-term complications throughout the study’s evaluation period. Therefore, both techniques may be indicated for surgical sterilization of cats, according to the surgeon’s preference and expertise. Cats that underwent ovariectomy did not require rescue analgesia and surgical time was shorter in that group