Univariate and multivariate analyses of prognostic factors for progression-free survival.

<p>Univariate and multivariate Cox regressions, with Kaplan-Meier estimations of the median, hazard ratio and p-value according to log-rank tests for progression-free survival. Nbr: number; Obs: observations; ULN: upper limit of normal.</p

Progression-free survival follows the alkaline phosphatase value.

<p>Progression-free survival follows the alkaline phosphatase value.</p

Comparison of AP values (in X ULN) follows the number of liver metastases (left panel) or tumor burden as a percentage of the total liver volume (right panel).

<p>Bar: median value, dot: mean value.</p

Characteristics of 49 patients with liver metastases from gastrointestinal neuroendocrine tumor grade 1 and 2; AP: Alkaline phosphatase, CGA: Chromogranin A, 5HIAA: Urinary 5 hydroxy-indole acetate acid; ULN: Upper limit of normal; mets: Metastases; D-Pas: Duodeno-pancreas.

<p>P values are given according to the Wilcoxon test for continuous variables and the Chi-squared test for categorical variables.</p