First-ever stroke and transient ischemic attack incidence and 30-day case-fatality rates in a population-based study in Argentina

Background and Purpose - Epidemiological data about stroke are scarce in low- and middle-income Latin-American countries. We investigated annual incidence of first-ever stroke and transient ischemic attack (TIA) and 30-day case-fatality rates in a population-based setting in Tandil, Argentina. Methods - We prospectively identified all first-ever stroke and TIA cases from overlapping sources between January 5, 2013, and April 30, 2015, in Tandil, Argentina. We calculated crude and standardized incidence rates. We estimated 30-day case-fatality rates. Results - We identified 334 first-ever strokes and 108 TIAs. Age-standardized incidence rate per 100 000 for Segi's World population was 76.5 (95% confidence interval [CI], 67.8-85.9) for first-ever stroke and 25.1 (95% CI, 20.2-30.7) for first-ever TIA, 56.1 (95% CI, 48.8-64.2) for ischemic stroke, 13.5 (95% CI, 9.9-17.9) for intracerebral hemorrhage, and 4.9 (95% CI, 2.7-8.1) for subarachnoid hemorrhage. Stroke incidence was slightly higher for men (87.8; 95% CI, 74.6-102.6) than for women (73.2; 95% CI, 61.7-86.1) when standardized for the Argentinean population. Thirty-day case-fatality rate was 14.7% (95% CI, 10.8-19.5) for ischemic stroke, 24.1% (95% CI, 14.2-36.6) for intracerebral hemorrhage, and 1.9% (95% CI, 0.4-5.8) for TIA. Conclusions - This study provides the first prospective population-based stroke and TIA incidence and case-fatality estimate in Argentina. First-ever stroke incidence was lower than that reported in previous Latin-American studies, but first-ever TIA incidence was higher. Thirty-day case-fatality rates were similar to those of other population-based Latin-American studies.Fil: Bahit, M. Cecilia. Ineco Neurociencias Oroño; ArgentinaFil: Coppola, Mariano L.. Hospital Municipal Sofía Santamarina; ArgentinaFil: Riccio, Patricia M.. Western University; CanadáFil: Cipriano, Lauren E.. Ivey Business School; CanadáFil: Roth, Gregory A.. University Of Washington; Estados UnidosFil: Lopes, Renato D.. Duke University Medical Center; Estados UnidosFil: Feigin, Valery L.. Auckland University Of Technology; Nueva ZelandaFil: Borrego Guerrero, Brenda. Sanatorio Tandil; ArgentinaFil: De Martino, Maximiliano. Hospital Municipal Sofía Santamarina; ArgentinaFil: Diaz, Alberto Alejandro. Hospital Municipal Sofía Santamarina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ferrante, Daniel. Ministerio de Salud de la Nación; ArgentinaFil: Funaro, Fernando. Nueva Clínica Chacabuco; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lavados, Pablo. Universidad del Desarrollo; Chile. Universidad de Chile; ChileFil: Lewin, M. Laura. Hospital Municipal Sofía Santamarina; ArgentinaFil: López, Daniel H.. Círculo Médico de Tandil; ArgentinaFil: Macarrone, Patricia. Nueva Clínica Chacabuco; ArgentinaFil: Marciello, Rafael. Hospital Municipal Sofía Santamarina; ArgentinaFil: Marino, Diego. Sanatorio Tandil; ArgentinaFil: Martens, Cecilia. Hospital Municipal Sofía Santamarina; ArgentinaFil: Martínez, Paula. Nueva Clínica Chacabuco; ArgentinaFil: Odriozola, Guillermo. Hospital Municipal Sofía Santamarina; ArgentinaFil: Rabinstein, Alejandro A.. Mayo Clinic; Estados UnidosFil: Saposnik, Gustavo. Saint Michael's Hospital University Of Toronto; CanadáFil: Silva, Damián. Hospital Municipal Sofía Santamarina; ArgentinaFil: Suasnabar, Ramón. Nueva Clínica Chacabuco; ArgentinaFil: Truelsen, Thomas. Rigshospitalet; DinamarcaFil: Uzcudun, Araceli. Hospital Municipal Sofía Santamarina; ArgentinaFil: Viviani, Carlos A.. Círculo Médico de Tandil; ArgentinaFil: Sposato, Luciano A.. Western University; Canad