Frequency of nucleotide mutations across the heavy chain variable gene segment in normal (black) and HIV-1 (red) antibodies.

<p>The <i>x</i>-axis shows amino acid numbering of FWR and CDR areas. Data adapted from Rosner et al. [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002321#pbio.1002321.ref022" target="_blank">22</a>] and Scheid et al. [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002321#pbio.1002321.ref021" target="_blank">21</a>].</p