Anti-influenza IgG-response after influenza-vaccination in IFNβ-treated patients and in healthy controls.

<p>The concentration of anti-influenza A (panel A) and anti-influenza B (panel B) IgG is shown as detected before (day 0) and at day 7, 14 and 28 after influenza vaccination in IFNβ-treated patients with MS (IFNβ) and healthy controls (HC) (red lines indicate the median ± IQR). The percentage of patients fulfilling IgG sero-protection criteria for influenza A (panel C) and influenza B (panel D) is shown before (day 0) and at day 7, 14 and 28 after influenza vaccination in IFNβ-treated patients with MS (IFNβ) and healthy controls (HC). The percentage of IFNβ-treated patients with MS (IFNβ), and healthy controls (HC), converting from sero-negative pre-vaccination to seroprotection following vaccination is shown for influenza A (panel E) and influenza B (panel F) (day 7–28). * indicates p< 0.05; ** indicates p< 0.001</p

Clinical changes.

<p>Clinical changes over treatment period of 16 weeks are shown. Four of the five patients showed improvements in 2 min walking distance (A), the MFM total score (B) and the MFM D1 subscore (C).</p

Study profile according CONSORT flow chart.

<p>Study profile according CONSORT flow chart.</p