42 research outputs found

    Synthesis, Spectral and Antimicrobial Studies of Lanthanide (III) Chloride Complexes with the Schiff’s Base Derived from 2-Benzimidazolyl Mercaptoaceto Hydrazide and 2-Acetyl Pyridine

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    AbstractFew lanthanide (III) chloride complexes with Schiff’s base obtained by the condensation of 2-benzimidazolyl mercaptoaceto hydrazide and 2-acetyl pyridine have been prepared and characterized on the basis of elemental analysis, molar conductance, magnetic, electronic, infrared and 1H NMR spectral studies, IR and 1H NMR spectra indicates coordination through azomethine nitrogen, pyridine ring nitrogen and the carbonyl oxygen of the hydrazone moiety. A coordination number eight is suggested for these complexes.  The ligand and complexes were screened for their antimicrobial activity.Keywords: Schiffs base; Lanthanide (III) chloride complexes; Antimicrobial activit

    REVIEW PAPER ON WORM GEAR ANAYLASIS

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    The worm & worm wheel is used in gear box of Winch machine for lifting sand bucket. During working worm wheel fails due to load coming on the teeth. The failure is due to stress concentration. The crack appears at central thickness of tooth. Hence the tooth breaks at the central thickness. The failure of wheel occurs within period of about 20 days. So the company has to replace the worm wheel which is not cost effective. The stress calculation of worm wheel at tooth thickness is a three dimensional problem. This paper represents the review of analysis of stress pattern by using 3D Photoelasticity techniques & FEA techniqu

    Efficacy of a high potency O1 Manisa monovalent vaccine against heterologous challenge with foot-and-mouth disease virus of O/SEA/Mya-98 lineage in sheep

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    Potency tests for commercial oil-adjuvanted foot-and-mouth disease (FMD) vaccines are usually carried out in cattle, using a full dose (2 ml) of vaccine and homologous virus challenge. However, in sheep the recommended vaccine dose is half of the cattle dose (1 ml) and most vaccines have not been potency tested for this species, especially with heterologous viruses. To determine the efficacy of a high potency (>6PD50) FMD virus (FMDV) O1Manisa vaccine in sheep, we carried out a study using a heterologous FMDV (FMDV O/SKR/2010 - Mya-98 strain) challenge. Groups of seven animals each were vaccinated with 2×, 1×, 1/2× or 1/4× dose (2 ml, 1 ml, 0.5 ml or 0.25 ml respectively) and challenged at 7 days post vaccination (dpv). Only 3 of the 7 sheep in the group vaccinated with 2 ml were protected. With 2 additional groups, receiving double or single doses and challenged at 14 dpv, 4 of 7 sheep were protected in each group. None of the sheep had measurable neutralising antibodies against the vaccine or challenge virus at 7 dpv. However, all vaccinated animals challenged at 14 dpv had a homologous neutralising response against FMDV O1 Manisa on the day of challenge and all but one animal also had a heterologous response to FMDV O/SKR/2010. Infectious FMDV and viral RNA could be found in nasal swabs between 1 and 6 days post challenge (dpc) in most vaccinated sheep, but those vaccinated with higher doses or challenged at 14 dpv showed significant decreases in the level of FMDV detection. Intermittent virus shedding was noticed between 1 and 35 dpc in all vaccinated groups, but persistent infection could be demonstrated only in 4 sheep (20%). This study showed that at the recommended dose, a high potency (>6 PD50) FMDV O1 Manisa vaccine does not protect sheep against a heterologous challenge at 7 dpv. However, partial protection was observed when a double dose was used at 7 dpv or when double or single dose vaccinated sheep were challenged at 14 dpv.Funding was provided in part by the livestock industries in Australia through Animal Health Australia (AHA). The relevant industry bodies are the Cattle Council of Australia, Australian Dairy Farmers, Australian Lot Feeders Association, Wool Producers Australia, Sheepmeat Council of Australia, Australian Pork Limited and the Goat Industry Council of Australia. The AHA funds are matched through the Meat and Livestock Australia Donor Company by the Australian Government under MLA Project P.PSH 0652. This work was also supported in part by USDA, Agricultural Research Service (ARS) (CRIS 1940-32000-057-00D). CS was recipient of a PIADC Research Participation Program fellowship administered by Oak Ridge Institute for Science and Education (ORISE) through an interagency agreement with the US Department of Energy.http://www.elsevier.com/locate/antiviral2018-09-30hj2017Production Animal Studie
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