Solitary keratoacanthoma involving upper lip: a diagnostic dilemma - case report and a brief review

Keratoacanthoma (KA) is a benign epithelial proliferative lesion which frequently occurs on the sun exposed areas of the skin. KA originates within the pilosebaceous apparatus of the skin and may be solitary or multiple. Solitary KA can be difficult to differentiate from squamous cell carcinoma (SCC) both clinically and microscopically. However, the clinical course of the lesion and its ability to self involute makes it a distinct clinical entity. Solitary KA appears on the vermilion border of the lower lips with some frequency. A case of keratoacanthoma involving the upper lip is reported presenting as an exophytic growth that resolved after excisional biopsy. Photo- graphic documentation of the case along with relevant management protocol is discussed. The article emphasizes the significance of recognizing such lesion and discriminating it from SCC thus carrying diagnostic and therapeutic implications. However, in case of dilemma it is prudent to assume that the lesion is SCC unless proved otherwise clinically or histologically

Clinical and Laboratory Profile of Children Presenting With Seizure in A Tertiary Care Hospital: An Observational Cross Section Study

Background: Seizure is one of the common causes of childhood hospitalization with significant mortality and morbidity. Current study is to find type, clinical, demographic, biochemical profile and neuroimaging of children presenting with  seizure to tertiary center in Department of pediatrics Government Medical College and Hospital, Aurangabad. Subjects & Methods: This was a hospital based, prospective cross-sectional study conducted in Department of pediatrics Government Medical College and Hospital Aurangabad. Total 260 children between the age of 1 months to 12 years attending epilepsy clinic during the study period, were studied for clinical features, types, biochemical profile, imaging studies, EEG, etc. Results: Higher prevalence in the age group of 1 month to 1 year with male predominance (male/female = 1.6: 1) was found. In the present study Loss of consciousness (35.76 %), fever (25.76 %), vomiting (23.84 %), and headache (10.38 %) were four leading clinical complaints observed in children presenting with seizures . Generalized tonic-clonic seizures were the most common seizure semiology among the study cases. Conclusion: Appropriate study on clinical, demographic, biochemical profile and neuroimaging study of patients can help in proper understanding of the disease burden and to take appropriate measures for its control. Keywords: Electroencephalogram (EEG), Computed tomography (CT), Magnetic resonance Imaging (MRI), generalized tonic clonic Seizure (GTCS