Encapsulation of water insoluble drugs in mesoporous silica nanoparticles using supercritical carbon dioxide

Mesoporous silica nanoparticles MCM – 41 were synthesized with two dimensional hexagonal p6mm symmetry, high specific surface area(~ 980m2/g) narrow pore size and an average particle size of 186 nm. The produced nanoparticles were used to encapsulate carbamazepine through a supercritical carbon dioxide process combined with various organic solvents. Supercritical processing was found to provide increased drug encapsulation. The loaded MCM - 41 nanoparticles were analyzed using X–ray diffraction and differential scanning calorimetry (DSC) to investigate the crystalline state of the encapsulated carbamazepine and it was found to be dependent on the nature of the organic solvent. Carbamazepine showed increased dissolution rates under sink conditions. Viability studies of Caco – 2 cells demonstrated negligible cytotoxicity for the MCM–41 nanoparticles

Experimental investigation of the response of a harmonically excited hard Duffing oscillator

A single degree-of-freedom torsional vibratory system, which constitutes a third-order dissipative dynamical system, has been fabricated as a mechanical analogue of hard Duffing equation with strong nonlinearity. The forced response of the system reveals complicated and chaotic motion at low frequency regime. Besides usual jump phenomenon, unpredictable jump phenomenon with two and three coexisting periodic attractors is also observed

An Algorithm to Avoid Confidential Data Theft from Storage Devices

No Abstrac

Novel Wireless Biometric System with Sensor Analysis

With increase in complexity of current Health & Disease scenario in society, Modern medical practices greatly relies on technology for analyzing patient’s health condition & for arriving at suitable best possible treatment. Use of technology is greatly assisting medical profession for quick & accurate decisions making but at the same time exponentially increasing medical expenses making it un-accessible to wide range of social class. Statistics reveal that every minute a human is losing his/her life across the globe. Motivation of this paper is to develop efficient & affordable wireless biometric system that can monitor multiple patients’ health parameters simultaneously and can effectively deliver the data to a patient monitoring system where it is stored permanently. It enables the doctors to monitor many parameters of patient’s health, in that our project investigates the potential of wireless biometric system to reliably, wirelessly collect, send and process the temperature & heart rate of multiple patients simultaneously. Thus we have designed and developed a reliable, energy efficient patient monitoring system. Use of suitable wireless communication technique to manage interference & accurately deliver information at user interface (output device) is one of major challenge that is considered here. We have tried to address this challenge by adopting scheduling scheme in data transmission & using unique ID for each patient’s noted parameters. The system also alerts the doctor/nurse of some measured value cross threshold limits. On the basis of monitored data performance evaluation is to be done which helps for performance of sensors. A data storage mechanism employed here become of help as a ready past data reference and remedial action by the doctor. At present, under current medical practice, there is individual patient monitoring system for every patient which makes it expensive, whereas our proposed system uses the same resources to monitor multiple patients, with more comfort and convenience which can pave way to distribute cost of system to multiple patients at the same time maintaining flexibility expected by and useful for the healthcare professionals. This project helps to provide a solution which not only is reliable and flexible but also affordable which is need of time considering huge burden of Medical Expenses which are hardly manageable by for vast range of patients

A parasitic myoma: clinicopathological study of a rare case

Leiomyoma is a benign tumour composed of smooth muscle cells with fibrous stroma and it is the commonest tumour amongst the tumours of uterus. As per FIGO classification system parasitic leiomyoma has no myometrial involvement or uterine attachment. These myomas get detached from the uterus and receive the blood supply from another source. The etiology and pathologic basis of these parasitic fibroids is not yet clearly understood. We report a rare case of parasitic myoma in a 29 years old female patient presented with abdominal discomfort and difficulty in micturition. Clinical examination and subsequent imaging studies revealed a pelvic mass. Histopathological examination of which proved it to be a parasitic myoma. Parasitic myoma is a rare entity which may be iatrogenically created after surgery particularly with morcellation technique. With increasing rates of laparoscopic procedures, surgeons should be aware of the possibility of formation of parasitic myoma and should take intraoperative precautions to minimise its formation

REVIEW ARTICLE: SOLUBILITY ENHANCEMENT BY SOLID DISPERSION

Enhancement of solubility, dissolution rate and bioavailability of the drug is a very challenging task in drug development, nearly 40% of the new chemical entities currently being discovered are poorly water soluble drugs. The solubility behaviour of the drugs remains one of the most challenging aspects in formulation development. This results in important products not reaching the market or not achieving their full potential. Solid dispersion is one of the techniques adopted for the formulation of such drugs and various methods are used for the preparation of solid dispersion. Solid dispersion is generally prepared with a drug which is having poor aqueous solubility and hydrophilic carrier. This article review various methods and concept of solid dispersion, criteria for drug selection, advantage and disadvantage, characterization, and application

Biometric Fusion and Recognition

Biometric is the science and technology of measuring and analyzing biological data of human body, extracting a feature set from the acquired data and comparing this set against the template set in the database. In this paper, Recognition through fusion of face and iris biometric images based on wavelet features and Kernel Fisher Discriminant Analysis (KFDA) is developed. Discrete Wavelet Transform (DWT) of face and iris image is used to reduce the dimensions which help to prevent from requirement of storage space of database. Nearest Neighbour classifier is selected to assign class to its nearest neighbour. Then, nonlinear original input space can be converted through a nonlinear map function into a linear high-dimensional feature space with the use of KFDA

SENSORIMOTOR CONTROL OF THE KNEE IN MALE AND FEMALE ATHLETES

Evidence suggests that the female predisposition to knee injuries may be related to sensorimotor control (Hewett et al., 2005). The purpose of this study was to compare the quadriceps and hamstrings muscle control strategies of male and female athletes using an established method of testing muscle control (Williams et al., 2003)

Integrating Fertilizer N Rates with Organics on Soil-Available Nutrients and Yield of Sapota under Semi-Arid Conditions of Karnataka

A field experiment was conducted for three consecutive years to study the effect of various combinations of nitrogenous fertilizer (in the form of urea), vermicompost and FYM on yield and soil-available nutrients in sapota. Largest number of fruits (4820 tree-1) and maximum fruit yield (31 tons ha-1) were recorded with 10kg vermicompost + 350:50:450g NPK tree-1, and was on par with application of 40kg FYM + 350:50:450g NPK tree-1. The net profit and yield trend over the years showed that application of 10kg vermicompost + 350:50:450g NPK tree-1 was more suitable for meeting nutrient requirement for enhanced yield in sapota. Application of organics (irrespective of source) showed positive, significant effect on organic matter content of the soil after three years. Highest build-up of organic matter in the soil was recorded with 10kg vermicompost alone (T10), which was at par with 40kg FYM alone (T5). Moreover, there was a clear trend of increasing total soil nitrogen content in plots supplied with increased levels of inorganic nitrogen with organic manures, and, this was subsequently reflected in potentially mineralized nitrogen, suggesting an improved labile pool of plant-available nitrogen. Therefore, there is an obvious need to include organic manures along with the inorganic nitrogenous fertilizer for optimizing the use-efficiency of soil and applied N to achieve sustainable yields in sapota for profit