FORMULATION AND EVALUATION OF BESIFLOXACIN NON-ERODIBLE OCULAR INSERTS

Objective: Ocular inserts offer many advantages over conventional dosage forms, like increased ocular residence, the possibility of releasing a drug at a slow and constant rate, accurate dosing, exclusion of preservatives, and increased shelf life. Besifloxacin is a very important drug for the treatment of infectious conjunctivitis. The present study was aimed to formulate and evaluate Besifloxacin Non-Erodible Ocular Insert using Pullulan and polyvinyl pyrrolidone as a drug reservoir, PEG 400 as a plasticizer, and Eudragit RS-100 as a rate-controlling membrane. Methods: Central composite design was employed to study the effect of independent variables, i.e., effects of Pullulan amount (X1) and PVP (X2) on the dependent variables, i.e., % moisture absorption and In vitro diffusion rate. After evaluation of all thirteen batches of ocular insert reservoir formulation, BSF2 and BSF4 were selected as a satisfactory formulation and was sandwiched between rate-controlling membrane, which was made up of Eudragit RS-100 (3 and 5%). Results: The drug content of all formulations was found to be in the range of 95.33 to 99.89 %. In vitro diffusion of Besifloxacin from reservoir formulations (BSF1 to BSF13) was found to be 62.44 to 70.62 %. In vitro diffusion rate of an ocular insert of Besifloxacin can offer benefits such as increasing residence time, prolonging drug release in the eye for 24 h. Eudragit RS-100, as a sustained drug release polymer, showed promising sustained released action. Conclusion: The study concluded that Besifloxacin non-erodible ocular inserts can be successfully developed using Pullulan and polyvinyl pyrrolidone, which will sustain the release of the drug also reduce the frequency of administration, and thereby may help to improve patient compliance

Face Recognition using SOM Network

This paper presents novel technique for recognizing faces. From the last two decades, face recognition is playing an important and vital role especially in the field of commercial, banking, social and law enforcement area. It is an interesting application of pattern recognition and hence received significant attention. The complete process of face recognition covers in three stages, face detection, feature extraction and recognition. Various techniques are then needed for these three stages. Also these techniques vary from various other surrounding factors such as face orientation, expression, lighting and background. The Self-Organizing Map (SOM) Neural Network has been used for training of database and simulation of FR system. In this paper the feature extraction methods discrete wavelet transform (DWT), discrete cosine transform (DCT) simulated in MATLAB are explained

Clinicopathological study of hysterectomised specimens

Background: Hysterectomy is the commonest major surgical procedure performed in gynecology. It can be done by abdominal or vaginal route and with the help of laparoscopy. Hysterectomy is an effective treatment option for many conditions like fibroid, abnormal uterine bleeding, endometriosis, adenomyosis, uterine prolapse, pelvic inflammatory disease and cancer of reproductive organ when other treatment options are contraindicated or have failed, or if the woman no longer wishes to retain her menstrual and reproductive. The aim and objective of the study was to correlate indications of hysterectomy with histopathological findings in hysterectomised patients.Methods: A retrospective study was carried on 113 hysterectomised cases over a period of one year from June 2015 to May 2016. The data regarding the patient’s age, parity, clinical diagnosis, type of hysterectomy and histopathological diagnosis were reviewed by the records and analyzed.Results: A total of 113 cases of hysterectomies were studied. Hysterectomies were distributed over a wide age ranging from 20 years to 75 years. Most common age group was 41-50 years. Among hystectomies majority were done through vaginal route 86 (76.1%) and 26 (23%) cases were done through abdominal route. Most common clinical diagnosis was fibroid uterus in 44(38.9%) cases. Most of the hysterectomies were done for benign conditions. In final histopathological report most common diagnosis was fibroid uterus in 45(39.8%) hysterectomy specimens. It was correlated well with clinical diagnosis. Next most common histopathological diagnosis was Adenomyosis.Conclusions: Histopathological analysis correlated well with preoperative clinical diagnosis in majority of cases. The commonest indication and histopathological finding in our study was fibroid uterus. Next most common histopathological finding was Adenomyosis. Most commonly hysterectomies were done through vaginal route in our study

Research Notes: G. B. Pant University of Agriculture and Technology

Singh et al. (1974) reported the inheritance as well as the pollen behaviour of 3 male-sterile lines of soybean , viz: \u27Semmes M.S.1\u27 , \u27Semmes M.S.2\u27 and \u27N 69-2774\u27. They observed monogenic inheritance with sterility being the recessive trait in all these lines. Semmes M.S.1 had nonfunctional pollen but of the same size as that of normal pollen grains; Semmes M.S.2 had no pollen at all, whereas N 69-2774 had nonfunctional pollen but these were much bigger as compared to the normal pollen grains

Fish Stupefying Plants Used by the Tribes of Nandurbar District.

The present paper deals with the identification of those plants which are used as natural toxins for capturing fishes from Nandurbar district of Maharashtra. Nandurbar district is tribal district, is rich in ethno biological diversity, its different tahasils have their own toxicant plants which can be used for capturing fishes. So this ethno biological survey was conducted in different tahasils of Nandurbar district viz Akkalkuwa, Dhadgaon, Shahada, Taloda, Nandurbar and Navapur. As fishes are the important source of protein for poor people living near the banks of rivers, they use few plants which are natural toxicants for fishes and capture the fishes. During this study, a number of toxicant plants are identified with the help of the people living near the river and dams. The general information related to vernacular name of the plant in different tahasil and plant parts used, have been identified by elders and knowledgeable people. Plants are identified taxonomically with the help of Botanist of Jijamata Education Society’s, Department of Botany For UG, PG and Research, Arts, Science and Commerce College, Nandurbar, Maharashtra. Extensive literature was also consulted for identification

Malignancy within a tail gut cyst:a case of retrorectal carcinoid tumour

Purpose. Tailgut cysts with malignant transformation are rare entities. We discuss the diagnostic strategy and treatment of a malignancy within a tailgut cyst. Methods. In this study we report on the case of a 61-year-old man with a malignant neuroendocrine tumour arising within a tailgut cyst and an overview of the literature emphasising the histopathological characteristics and differential diagnosis. Results. Our patient presented with lower back pain, rectal pain, and increased urgency of defecation. MRI scan and CT-guided biopsy on histological analysis revealed a diagnosis of carcinoid tumour of the presacral space. The patient subsequently underwent an abdominoperineal excision of the rectum. Conclusions. This case highlights the importance of tailgut cysts as a differential diagnosis of presacral masses. It is a rare congenital lesion developing from remnants of the embryonic postanal gut and is predominantly benign in nature. Approximately half of cases remain asymptomatic; therefore, diagnosis is often delayed. Magnetic resonance imaging is the investigation of choice and an awareness of the possibility of malignant potential is critical to avoiding missed diagnosis and subsequent morbidity. Complete surgical excision allows accurate diagnosis, confirmation of oncological clearance, and prevention of mortality

Nondescent vaginal hysterectomy: analysis of indications and complications

Background: Hysterectomy is the commonest major surgical procedure performed in gynecology. It can be done by abdominal or vaginal route and with the help of laparoscopy. Laparoscopic assisted vaginal hysterectomy (LAVH) and total laparoscopic hysterectomy (TLH) although gaining more popularity now a days, though it is associated with higher cost, longer duration of operation, and need general anaesthesia. The latest value study concluded that major haemorrhage, hematoma, ureteric injury, bladder injury, and anesthetic complications were more in laparoscopic assisted hysterectomy (LAVH) group when compared to abdominal and vaginal hysterectomies. In addition LAVH was accomplished in twice the time required for vaginal hysterectomy.The objective of the study was to analyse the indication and to study the complications of nondescent vaginal hysterectomy.Methods: This is a retrospective cohort study.  60 women who underwent nondescent vaginal hysterectomy in the department of OBG, B.G.S. Global Institute of Medical Sciences, Banglore, India were included in the study. Patients’ records were retrieved. Data regarding patient’s age, parity, indications for hysterectomy, uterine size in weeks, previous surgeries in the past, duration of surgery and complications were recorded. Data collected on a semi structured proforma and the same was analysed using suitable statistical analysis.Results: A total of 60 cases were operated for different indications. Among the study participants majority were in the age group of 41-45 years with 28 (46.7%). Most common indication for hysterectomies were dysfunctional uterine bleeding (DUB) with 27 (45%), followed by fibroid uterus 15 (25%). The mean duration of surgery time taken was 50+10minutes. Majority of the women who underwent hysterectomies had bulky uterus with 42 (70%).  Complications were very few. Fever, UTI (urinary tract infection) and headache were seen in 3 (5%) cases. There was one case of vault sepsis and one case of upper respiratory tract infection (URTI). In one patient vaginal hysterectomy could not be completed and abdominal hysterectomy was carried out. Mean hospital duration was 4 days.Conclusions: Vaginal hysterectomy is the least invasive with fewer complications and most economical route for hysterectomy. Nondescent vaginal hysterectomy should be the gynaecologists first choice for hysterectomy

Direct to consumer advertising via the Internet, a study of hip resurfacing

With increased use of the internet for health information and direct to consumer advertising from medical companies, there is a concern about the quality of the information available for patients. The aim of this study was to examine the quality of health information on the internet for hip resurfacing. An assessment tool was designed to measure quality of information. Websites were measured on credibility of source; usability; currentness of the information; content relevance; content accuracy/completeness and disclosure/bias. Each website assessed was given a total score, based on number of scores achieved from the above categories websites were further analysed on author, geographical origin and possession of an independent credibility check. There was positive correlation between the overall score for the website and the score of each website in each assessment category. Websites by implant companies, doctors and hospitals scored poorly. Websites with an independent credibility check such as Health on the Net (HoN) scored twice the total scores of websites without. Like other internet health websites, the quality of information on hip resurfacing websites is variable. This study highlights methods by which to assess the quality of health information on the internet and advocates that patients should look for a statement of an "independent credibility check" when searching for information on hip resurfacing

Attenuation in Artificially Dredged Channels for Ports Wave

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchiv