FORMULATION AND EVALUATION OF MUCOADHESIVE BUCCAL PATCHES OF PIROXICAM

The main objective of present investigation to formulate and evaluate mucoadhesive buccal patches of Piroxicam, using solvent casting method. HPMC K100 M were used as a mucocoadhesive polymer and PEG 400 used as a plasticizer as well as penetration enhancers. The formulated patches of piroxicam were evaluated for their appearance, weight variation, thickness, folding endurance, surface pH, swelling index, drug content, % elongation, mucoadhesive strength, in vitro drug release, kinetic release study and stability study. Among all formulated batches (S1-S8) of buccl patches batch S6 showing maximum drug release after 8 hours 94.77 % and mucoadhesive strength 10.21±0.35g). The stability study optimized batch S6 doesn’t show any changes with respect to previous evaluation carried out before stability study. It may concluded the mucoadhesive buccal patches of Piroxicam were successfully prepared using HPMC K100 M by solvent casting method, evaluated & it is better alternative to conventional drug delivery for the management of pain and arthititis

FORMULATION AND CHARACTERIZATION OF MUCOADHESIVE MICROSPHERES OF GLICLAZIDE HYDROCHLORIDE

This article illustrates the Formulation and Characterization of Mucoadhesive microspheres of Gliclazide Hydrochloride.The mucoadhesive microspheres were prepared by the Emulsion Solvent Evaporation method by using Eudragit L 100 and Ethyl Cellulose 22 CPS polymers & PEG 4000 added as a pore forming agent . Formulated microspheres were evaluated for various parameters. The characteristics like shape and structure of prepared microspheres were determined by Optical microscopy and scanning electron microscopy respectively. The prepared microspheres exhibited prolonged drug release (12 hrs) the mean particle size increased as the concentration of Eudragit L 100 increased. Decrease in size of microspheres leads to decrease in mucoadhesion time, % drug loading and faster the drug release. The optimized formulation shows following cumulative release after 12 hrs i.e. 96.40%. The microspheres exhibited 80% mucoadhesion and showed good drug entrapment efficiency i.e. 80.13±0.91% as well as drug loading efficiency is 26.70±0.75%.  It can be concluded that the present mucoadhesive microspheres can be an ideal system to deliver the Gliclazide Hydrochloride in the sustained release manner for management of Type II Diabetes Mellitus. Keywords: Mucoadhesive, Gliclazide Hydrochloride, Microspheres, Eudragit L 100, drug entrapment efficiency.Â