How kinetics drives the two- to three-dimensional transition in semiconductor strained heterostructures: the case of InAs/GaAs(001)

The two- to three-dimensional growth transition in the InAs/GaAs(001) heterostructure has been investigated by atomic force microscopy. The kinetics of the density of three dimensional quantum dots evidences two transition thresholds at 1.45 and 1.59 ML of InAs coverage, corresponding to two separate families, small and large. Based on the scaling analysis, such families are characterized by different mechanisms of aggregation, involving the change of the critical nucleus size. Remarkably, the small ones give rise to a wealth of "monomers" through the erosion of the step edges, favoring the explosive nucleation of the large ones.Comment: 10 pages, 3 figures. Submitted to Phys. Rev. Let

RGS4 controls secretion of von Willebrand factor to the subendothelial matrix

The haemostatic protein von Willebrand Factor (VWF) exists in plasma and subendothelial pools; the former secreted from endothelial storage granules, Weibel-Palade bodies (WPBs), by basal secretion with a contribution from agonist-stimulated secretion, the latter secreted into the subendothelial matrix by a constitutive pathway, not involving WPBs. We set out to determine if the constitutive release of subendothelial VWF is actually regulated and if so, what functional consequences this might have. Constitutive VWF secretion can be increased by a range of factors; changes in VWF expression, levels of TNF-alpha or other environmental cues. An RNAseq analysis revealed that expression of RGS4 (Regulator of G protein signalling 4) was reduced in endothelial cells (HUVECs) grown under these conditions. si-RGS4 treatment of HUVECs increased constitutive basolateral secretion of VWF, probably by affecting the anterograde secretory pathway. In a simple model of endothelial damage we show that RGS4-silenced cells increased platelet recruitment onto the subendothelial matrix under flow. These results show that changes in RGS4 expression alter levels of subendothelial VWF, affecting platelet recruitment. This introduces a novel control over VWF function

k-String tensions and the 1/N expansion

We address the question of whether the large-N expansion in pure SU(N) gauge theories requires that k-string tensions must have a power series expansion in 1/N^2, as in the sine law, or whether 1/N contributions are also allowable, as in Casimir scaling. We find that k-string tensions may, in fact, have 1/N corrections, and consistency with the large-N expansion in the open-string sector depends crucially on an exact cancellation, which we will prove, among terms involving odd powers of 1/N in particular combinations of Wilson loops. It is shown how these cancellations are fulfilled, and consistency with the large-N expansion achieved, in a concrete example, namely, strong-coupling lattice gauge theory with the heat-kernel action. This is a model which has both a 1/N^2 expansion and Casimir scaling of the k-string tensions. Analysis of the closed string channel in this model confirms our conclusions, and provides further insights into the large-N dependence of energy eigenstates and eigenvalues.Comment: RevTeX4, 21 pages. Typos corrected, references added, some discussions expanded; conclusions unchanged. Version to appear on PR

Genetic structure of cultivated varieties of radicchio (Cichorium intybus l.): A comparison between F1 hybrids and synthetics

Cichorium intybus L., well known in Italy with the common name "Radicchio", is an important leafy vegetable that is prevalently reproduced by allogamy due to very efficient barriers of self-incompatibility. Marker-assisted breeding is widely used by seed firms to develop new hybrid varieties that manifest genetic distinctiveness, uniformity and stability. A total of 29 mapped microsatellite markers were used for genotyping 504 samples of the Red of Chioggia biotype: First, two synthetics, four F1 hybrids and two derived F2 populations were compared to assess the distinctiveness of their gene pool and structure; then, the uniformity and stability of 3 years of production of a commercial F1 variety were also investigated. Genetic similarity and diversity statistics as well as the genetic structure of populations were analysed, including allele and genotype frequencies. The mean estimates and ranges of genetic similarity enabled the molecular discrimination of OP synthetics from F1 varieties and their F2 progenies and the determination of individual plant memberships. Moreover, the genetic structure of F1 hybrids produced in 3 years unexpectedly revealed two main clusters that discriminate the first 2 years from the 3rd, mainly because of the presence of uncommon specific alleles and different allele frequencies. Overall, this molecular information will enable breeders to determine the genetic distinctness, uniformity and stability of commercial and experimental varieties, as well as their genetic relationships and relatedness. Hence, this work provides a useful tool for achieving the molecular characterisation and genetic identification of different radicchio populations

Degeneracy Between the Regge Slope of Mesons and Baryons from Supersymmetry

We consider the degeneracy between the Regge slope of mesons and baryons in QCD. We argue that within the "orientifold large-N approximation" asymptotically massive mesons and baryons become supersymmetric partners and hence degenerate. To this end, we generalize QCD by a SU(N) theory with a quark in the two-index antisymmetric representation. We show that in this framework the meson is represented by an oriented bosonic QCD-string and the baryon is represented by an un-oriented fermionic QCD-string. At large-N, due to an equivalence with super Yang-Mills, the tensions of the bosonic and the fermionic strings coincide. Our description of mesons and baryons as oriented and un-oriented bosonic and fermionic QCD-strings is in full agreement with the spectra of open strings in the dual type 0' string theory.Comment: v2: extended version. Appendices and references adde

Renormalization constants of the lattice energy momentum tensor using the gradient flow

We employ a new strategy for a non perturbative determination of the renormalized energy momentum tensor. The strategy is based on the definition of suitable lattice Ward identities probed by observables computed along the gradient flow. The new set of identities exhibits many interesting qualities, arising from the UV finiteness of flowed composite operators. In this paper we show how this method can be used to non perturbatively renormalize the energy momentum tensor for a SU(3) Yang-Mills theory, and report our numerical results

A precise determination of the psibar-psi anomalous dimension in conformal gauge theories

A strategy for computing the psibar-psi anomalous dimension at the fixed point in infrared-conformal gauge theories from lattice simulations is discussed. The method is based on the scaling of the spectral density of the Dirac operator or rather its integral, the mode number. It is relatively cheap, mainly for two reasons: (a) the mode number can be determined with quite high accuracy, (b) the psibar-psi anomalous dimension is extracted from a fit of several observables on the same set of configurations (no scaling in the Lagrangian parameters is needed). As an example the psibar-psi anomalous dimension has been computed in the SU(2) theory with 2 Dirac fermions in the adjoint representation of the gauge group, and has been found to be 0.371(20). In this particular case, the proposed strategy has proved to be very robust and effective.Comment: LaTeX, 16 pages, 3 PDF figures, [v3] minor cosmetic change

Early cross-sectional imaging following open and laparoscopic cholecystectomy : a primer for radiologists

Abstract: Performed on either an elective or urgent basis, cholecystectomy currently represents the most common abdominal operation due to the widespread use of laparoscopy and the progressively expanded indications. Compared to traditional open surgery, laparoscopic cholecystectomy minimised the duration of hospitalisation and perioperative mortality. Albeit generally considered safe, cholecystectomy may result in adverse outcomes with non-negligible morbidity. Furthermore, the incidence of worrisome haemorrhages and biliary complications has not been influenced by the technique shift. Due to the growing medico-legal concerns and the vast number of cholecystectomies, radiologists are increasingly requested to investigate recently operated patients. Aiming to increase familiarity with post-cholecystectomy cross-sectional imaging, this paper provides a brief overview of indications and surgical techniques and illustrates the expected early postoperative imaging findings. Afterwards, most iatrogenic complications following open, converted, laparoscopic and laparo-endoscopic rendezvous cholecystectomy are reviewed with examples, including infections, haematoma and active bleeding, residual choledocholithiasis, pancreatitis, biliary obstruction and leakage. Multidetector computed tomography (CT) represents the \u201cworkhorse\u201d modality to rapidly investigate the postoperative abdomen in order to provide a reliable basis for an appropriate choice between conservative, interventional or surgical treatment. Emphasis is placed on the role of early magnetic resonance cholangiopancreatography (MRCP) and additional gadoxetic acid-enhanced MRCP to provide a non-invasive anatomic and functional assessment of the operated biliary tract. Teaching Points: \u2022 Having minimised perioperative mortality and hospital stay, laparoscopy has now become the first-line approach to performing cholecystectomy, even in patients with acute cholecystitis. \u2022 Laparoscopic, laparo-endoscopic rendezvous, converted and open cholecystectomy remain associated with non-negligible morbidity, including surgical site infections, haemorrhage, residual lithiasis, pancreatitis, biliary obstruction and leakage. \u2022 Contrast-enhanced multidetector computed tomography (CT) is increasingly requested early after cholecystectomy and represents the \u201cworkhorse\u201d modality that rapidly provides a comprehensive assessment of the operated biliary tract and abdomen. \u2022 Magnetic resonance cholangiopancreatography (MRCP) is the best modality to provide anatomic visualisation of the operated biliary tract and is indicated when biliary complications are suspected. \u2022 Additional gadoxetic acid (Gd-EOB-DTPA)-enhanced MRCP non-invasively provides functional biliary assessment, in order to confirm and visualise bile leakage

Shrinking Weibel‐Palade bodies prevents high platelet recruitment in assays using thrombotic thrombocytopenic purpura plasma

Background: Thrombotic thrombocytopenic purpura (TTP), caused by a genetic or autoimmune-driven lack of ADAMTS-13 activity, leads to high levels of the ultra-large von Willebrand factor (VWF) multimers produced by endothelial cells, causing excess platelet recruitment into forming thrombi, often with mortal consequences. Treatments include plasma infusion or replacement to restore ADAMTS-13 activity, or prevention of platelet recruitment to VWF. // Objectives: We tested a different approach, exploiting the unique cell biology of the endothelium. Upon activation, the VWF released by exocytosis of Weibel-Palade bodies (WPBs), transiently anchored to the cell surface, unfurls as strings into flowing plasma, recruiting platelets. Using plasma from patients with TTP increases platelet recruitment to the surface of cultured endothelial cells under flow. WPBs are uniquely plastic, and shortening WPBs dramatically reduces VWF string lengths and the recruitment of platelets. We wished to test whether the TTP plasma-driven increase in platelet recruitment would be countered by reducing formation of the longest WPBs that release longer strings. // Methods: Endothelial cells grown in flow chambers were treated with fluvastatin, one of 37 drugs shown to shorten WPBs, then activated under flow in the presence of platelets and plasma of either controls or patients with TTP. // Result: We found that the dramatic increase in platelet recruitment caused by TTP plasma is entirely countered by treatment with fluvastatin, shortening the WPBs. // Conclusions: This potential approach of ameliorating the endothelial contribution to thrombotic risk by intervening far upstream of hemostasis might prove a useful adjunct to more conventional and direct therapies