DESIGN AND DEVELOPMENT OF RILPIVIRINE NANOPARTICLE CONTAINING CHITOSAN USING IONIC GELATION METHOD FOR HIV INFECTIONS

Objective: The primary objective of the current research was to prepare rilpivirine loaded Nanoparticles containing Chitosan using the ionic gelation method for HIV infections. Methods: The nanoparticles of rilpivirine were prepared using the ionic gelation technique. Further, nanoparticles were characterized by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and in vitro drug release. Results: The optimized nanoparticles were found with a particle size of 130.30±5.29 nm (mean±SD) and entrapment efficiency (% EE) of 77.10±0.50%. Scanning electron microscopy technique exposed spherical particles with uniform size. It was observed that the nanoparticles created showed the absence of the crystalline nature of the drug and its switch to the amorphous state. Results showed that more than 45% of the pure drug is released in 50 min and after 90 min almost about 95% of the drug is released. Conclusion: The research study concluded that the in vitro release profile of nanoparticles was found to be sustained up to 24 hr. Sustained release of the rilpivirine could improve patient obedience to drug regimens, growing action effectiveness.&nbsp

Charged analogue of Finch-Skea stars

We present solutions to the Einstein-Maxwell system of equations in spherically symmetric gravitational fields for static interior spacetimes with a specified form of the electric field intensity. The condition of pressure isotropy yields three category of solutions. The first category is expressible in terms of elementary functions and does not have an uncharged limit. The second category is given in terms of Bessel functions of half-integer order. These charged solutions satisfy a barotropic equation of state and contain Finch-Skea uncharged stars. The third category is obtained in terms of modified Bessel functions of half-integer order and does not have an uncharged limit. The physical features of the charged analogue of the Finch-Skea stars are studied in detail. In particular the condition of causality is satisfied and the speed of sound does not exceed the speed of light. The physical analysis indicates that this analogue is a realistic model for static charged relativistic perfect fluid spheres.Comment: 17 pages, To appear in Int. J. Mod. Phys.

Characteristics of Fatal Cases of Pandemic Influenza A (H1N1) from September 2009 to January 2010 in Saurashtra Region, India

Background: India reported first case of 2009 pandemic influenza A (H1N1) virus infection in May, 2009 and Saurashtra region in August, 2009. We describe the characteristics of fatal cases of 2009 influenza A (H1N1) infection reported in Saurashtra region. Methods: From September, 2009 to January, 2010, we observed 71 fatal cases that were infected with 2009 influenza A (H1N1) virus and admitted in different hospitals in Rajkot city. Real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) testing was used to confirm infection; the clinico-epidemiological features were observed and documented. Results: Median age of the deceased (71) was 29 years, and 57.7% were females. Median time observed was 5 days from onset of illness to diagnosis of influenza A (H1N1), and 57.7% were referred from general practitioner (OR=0.42, CI=0.24-0.74). Median hospital stay reported was 3 days. All admitted patients received oseltamivir, but only 16.9% received it within 2 days of onset of illness. The most common symptoms were cough (97.2%), fever (93%), sore throat and shortness of breath. Co-morbid conditions were present in almost half of the patients who ultimately died, the most common of which was pregnancy (OR=0.15, CI=0.04-0.52). Radiological pneumonia was reported in 98% patients. Conclusion: Residing in urban area, delayed referral from general practitioner, presence of co-existing condition, especially pregnancy was responsible for mortality among influenza A (H1N1) infected positive

Analysis of Security Threats in Voice Over Internet Protocol (VOIP)

The VoIP system is build on the IP network, so it is affected by the IP network security problem. It has many security problems because of the security mechanism of VoIP system and other external factors. These effects relate to the following three aspects: confidentiality, integrity and availability. This paper makes a detailed analysis discussed several security potential threats by dividing it into several categories like social, eavesdropping, service abuse, etc. and finally shows how this threats are harmful to VoIP. Keywords-VoIP; Security threat

Broadband study of blazar 1ES 1959+650 during flaring state in 2016

Aim : The nearby TeV blazar 1ES 1959+650 (z=0.047) was reported to be in flaring state during June - July 2016 by Fermi-LAT, FACT, MAGIC and VERITAS collaborations. We studied the spectral energy distributions (SEDs) in different states of the flare during MJD 57530 - 57589 using simultaneous multiwaveband data to understand the possible broadband emission scenario during the flare. Methods : The UV/optical and X-ray data from UVOT and XRT respectively on board Swift and high energy $\gamma$-ray data from Fermi-LAT are used to generate multiwaveband lightcurves as well as to obtain high flux states and quiescent state SEDs. The correlation and lag between different energy bands is quantified using discrete correlation function. The synchrotron self Compton (SSC) model was used to reproduce the observed SEDs during flaring and quiescent states of the source. Results : A decent correlation is seen between X-ray and high energy $\gamma$-ray fluxes. The spectral hardening with increase in the flux is seen in X-ray band. The powerlaw index vs flux plot in $\gamma$-ray band indicates the different emission regions for 0.1 - 3 GeV and 3-300 GeV energy photons. Two zone SSC model satisfactorily fits the observed broadband SEDs. The inner zone is mainly responsible for producing synchrotron peak and high energy $\gamma$-ray part of the SED in all states. The second zone is mainly required to produce less variable optical/UV and low energy $\gamma$-ray emission. Conclusions : Conventional single zone SSC model does not satisfactorily explain broadband emission during observation period considered. There is an indication of two emission zones in the jet which are responsible for producing broadband emission from optical to high energy $\gamma$-rays.Comment: 11 pages, 12 figures, Accepted in A&

Spatial Numerical Range in Non-unital, Normed algebras and their Unitizations

Let $(A, \|\cdot\|)$ be any normed algebra (not necessarily complete nor unital). Let $a \in A$ and let $V_A(a)$ denote the spatial numerical range of $a$ in $(A, \|\cdot\|)$. Let $A_e = A + {\mathbb C} 1$ be the unitization of $A$. If $A$ is faithful, then we get two norms on $A_e$; namely, the operator norm $\|\cdot\|_{op}$ and the $\ell^1$-norm $\|\cdot\|_1$. Let $A^{op} = (A, \|\cdot\|_{op})$, $A_e^{op} = (A_e, \|\cdot\|_{op})$, and $A_e^1 = (A_e, \|\cdot\|_1)$. We can calculate the spatial numerical range of $a$ in all these three normed algebras. Because the spatial numerical range highly depend on the identity as well as on the completeness and the regularity of the norm, they are different. In this paper, we study the relations among them. Most of the results proved in \cite{BoDu:71, BoDu:73} will become corollaries of our results. We shall also show that the completeness and regularity of the norm is not required in \cite[Theorem 2.3]{GaHu:89}.Comment: 8 page

The role of artificial intelligence in prospective real-time histological prediction of colorectal lesions during colonoscopy: a systematic review and meta-analysis

Artificial intelligence (AI) presents a novel platform for improving disease diagnosis. However, the clinical utility of AI remains limited to discovery studies, with poor translation to clinical practice. Current data suggests that 26% of diminutive pre-malignant lesions and 3.5% of colorectal cancers are missed during colonoscopies. The primary aim of this study was to explore the role of artificial intelligence in real-time histological prediction of colorectal lesions during colonoscopy. A systematic search using MeSH headings relating to “AI”, “machine learning”, “computer-aided”, “colonoscopy”, and “colon/rectum/colorectal” identified 2290 studies. Thirteen studies reporting real-time analysis were included. A total of 2958 patients with 5908 colorectal lesions were included. A meta-analysis of six studies reporting sensitivities (95% CI) demonstrated that endoscopist diagnosis was superior to a computer-assisted detection platform, although no statistical significance was reached (p = 0.43). AI applications have shown encouraging results in differentiating neoplastic and non-neoplastic lesions using narrow-band imaging, white light imaging, and blue light imaging. Other modalities include autofluorescence imaging and elastic scattering microscopy. The current literature demonstrates that despite the promise of new endoscopic AI models, they remain inferior to expert endoscopist diagnosis. There is a need to focus developments on real-time histological predictions prior to clinical translation to demonstrate improved diagnostic capabilities and time efficiency

On the convexity of spatial numetical range in normed algebras

In this article, we address the following question: Is it true that the spatial numerical range (SNR) $V_A(a)$ of an element $a$ in a normed algebra $(A, \|\cdot\|)$ is always convex? If the normed algebra is unital, then it is convex \cite[Theorem 3, P.16]{BoDu:71}. In non-unital case, we believe that the problem is still open and its answer seems to be negative. In search of such a normed algebra, we have proved that the SNR $V_A(a)$ is convex in several non-unital Banach algebras.Comment: 9 page