Reliability/cost evaluation of a wind power delivery system

Renewable energy policies, such as the Renewable Portfolio Standard, arising from increasing environmental concerns have set very ambitious targets for wind power penetration in electric power systems throughout the world. In many cases, the geographical locations with good wind resources are not close to the main load centers. It becomes extremely important to assess adequate transmission facility to deliver wind power to the power grid. Wind is a highly variable energy source, and therefore, transmission system planning for wind delivery is very different from conventional transmission planning. Most electric power utilities use a deterministic ‘n-1’ criterion in transmission system planning. Deterministic methods cannot recognize the random nature of wind variation that dictates the power generated from wind power sources. This thesis presents probabilistic method to evaluate the contribution of a wind power delivery system to the overall system reliability. The effects of site-specific wind regime, system load, transmission line unavailability, and redundancy on system reliability were studied using a basic system model. The developed method responds to the various system parameters and is capable of assessing the actual system risks. Modern power system aims to provide reliable as well as cost effective power supply to its consumers. Reliability benefits, environmental benefits and operating cost savings from wind power integration should be compared with the associated investment costs in order to determine optimum transmission facility for wind power delivery. This thesis presents the reliability/cost techniques for determining appropriate transmission line capacity to connect a wind farm to a power grid. The effect of transmission system cost, line length, wind regime, wind penetration and customer interruption cost on the optimum transmission line sizing were studied using a basic system model. The methodology and results presented in this thesis should be useful in transmission system planning for delivering wind power to a power system

Ayurvedic Management of Chronic Simple Rhinitis - A Case Study

Chronic simple rhinitis can be correlated with Vata-Kaphaja Pratishyaya. Treatment of Pratishyaya is either Shodhana or Shamana, According to Bala and Dosha of the Patient. In Pratishyaya choice of Shodhana treatment can be Nasya, Vamana, Niruhabasti, which helps to remove the vitiated Dosha from Shira (Head), Aamashaya with Pakvashaya and breakdown the Samprapti of Pratishyaya. Pachana medicine is prior required for proper Shodhana and Rasayana medicine provide best result after Shodhana. In this case of Pratishyaya the line of treatment is Pachana, Nasya, Niruhabasti, Vamana and Vardhman Pippali Rasayana, patient get started relief from first day of treatment and complete relief after Vamana and also not get the recurrence after completion of Vardhman Pippali Rasayana

Role of Uttarabasti in the management of Functional Bladder Outlet Obstruction: A Case Study

Bladder outlet obstruction (BOO) produces compression or resistance upon the bladder outflow channel at any location from the bladder neck to urethral meatus. It may be induced by specific functional and anatomic causes. Functional obstruction may be caused by detrusor-sphincter dyssynergia (DSD) and anatomic obstruction most commonly from benign prostatic enlargement (BPH) or urethral stricture. Obstructive symptoms include hesitancy, sensation of incomplete bladder emptying, diminished urinary stream. The combination of PVR, urinary flow measures, and symptom appraisal has been generally accepted as the initial screening and evaluation paradigm for BOO. In, Ayurveda, BOO is similar to Mutraghata means obstruction in the urine flow. Uttarbasti is the prime treatment of Mutraghata. Present case is diagnosed as a functional bladder outlet obstruction (BOO) on the basis of symptoms, normal reports of USG and ascending urethrogram and diminished flow of urine in Uroflowmetry. Total 7 Uttarbasti with 50ml Sahcharadi Tailam was given along with Rasayana and Mutraghatahara medicine. Patient has complete relief in his obstructive urine complains and has normal urine flow without taking Tab. AFDURA after 7 years. And also improvement appear in Uroflowmetry

Relationship Between Investment Popularity and Accounting Information: Evidence from the UK Equity Crowdfunding Market

This study looks at the use of accounting disclosure in equity crowdfunding to understand how accounting and financial reporting facilitates start-up financing. Results find no relation between historical accounting disclosure and start-up capital obtained from crowdfunding investors, on average. However, results show that there is a relationship between firms set campaign characteristics, such as equity offered and the threshold of voting rights, and campaign success. This study also examines investors’ demand for the financial health of crowdfunding campaigns that disclose financial statements, through the use of traditional accounting ratios, and finds that investors may not take in to consideration the current financial standings of the companies they choose to invest in. Finally, this study finds a negative relation between the number of investors a campaign attracts and the entrepreneur’s long-term forecasts of expected future profits. The results provide insight into the demand for financial reporting in an unregulated market, and informs the debate on proposed crowdfunding regulation

Exaggerated neutrophil immunosenescence in sepsis and its potential modification with simvastatin

Sepsis remains a common reason for hospital admission and is associated with a high mortality especially in the elderly. Neutrophils are one of the primary immune cells involved in the elimination of pathogens; however also contribute to the pathogenesis of multi-organ failure in sepsis. Previous studies have demonstrated an age-related decline in neutrophil migration and phagocytosis suggesting this as a mechanism for the poorer outcomes observed from sepsis in the elderly. Observational studies suggest that HMG-CoA reductase inhibitors (statins) are associated with improved outcomes from sepsis and potentially modulate neutrophil function. This thesis demonstrates that high dose (80mg) simvastatin improved the migration of neutrophils in the healthy elderly without affecting other key neutrophil functions, such as phagocytosis and reactive oxygen species production (ROS). Studies in patients with sepsis, demonstrated that circulating neutrophils displayed features of immune-paresis and failed to migrate, but were activated with increased phagocytosis and ROS. This was accompanied by reduced neutrophil extracellular trap (NET) formation and delayed late apoptosis. The use of in-vitro simvastatin failed to modulate migration, whilst ROS and NET production was reduced by simvastatin. Simvastatin remains a potential immune-modulating drug for treating early infection in the elderly

A retrospective study of drug prescribing pattern in burns patients in a tertiary care rural hospital

Background: To study and describe the prevailing prescription trend in burns patients in a tertiary care rural hospital.Methods: This was a retrospective observational study. Total 100 patients diagnosed with burn injury and admitted during Jan 2012 to Dec 2013 were included in the study. The demographic details, details of burn injury & treatment received were obtained from the medical record section of Dhiraj General Hospital, Piparia. Drug prescriptions were analyzed using Microsoft Excel for total number of drugs per prescription, various classes of drugs prescribed and group of antibiotics commonly prescribed.Results: Most common age group affected was 20-40 years. The female to male ratio was 1.8:1. Average number of drugs prescribed was 6.8 with a range of 4-9 drugs per prescription. All prescriptions (100%) contain antimicrobials, analgesics and antiulcer drugs. Among antimicrobials, ceftriaxone was most commonly prescribed followed by amikacin and amoxicillin + clavulanic acid. Only 18% patients were immunized against tetanus.Conclusions: Females are more vulnerable to burn injuries. Polypharmacy was observed in prescriptions. Systemic antibiotic should be used with caution to prevent emergence of resistant microorganisms. Results of the present study indicate that some aspects of drug treatment need to be rationalized in order to achieve better patient care.

A snapshot of compliance with the sepsis six care bundle in two acute hospitals in the West Midlands, UK

The sepsis six care bundle has been adopted by hospitals in England and Wales for the management of patients with sepsis, with the aim of increasing survival when all elements of the bundle are achieved. To assess compliance with the Sepsis Six Care Bundle in two acute NHS hospitals in the West Midlands. Adults admitted to hospital over a 24-hour period were screened for sepsis. Sepsis was identified using the Systemic Inflammatory Response (SIRS) criteria and the quick sequential organ failure assessment (qSOFA) score. Adherence to the Sepsis Six Care Bundle was assessed. 249 patients were screened and 24 patients were identified as having sepsis (9.6%). One patient received all six elements of the bundle. Compliance was highest for giving intravenous fluids (58.3%) and antibiotics (58.3%), and lowest for measuring urine output (16.7%). Further research is needed to establish the reasons for low compliance. Frankling C, Patel J, Sharif B, Melody T, Yeung J, Gao F, et al. A Snapshot of Compliance with the Sepsis Six Care Bundle in Two Acute Hospitals in the West Midlands, UK. Indian J Crit Care Med 2019;23(7):310-315

Apnoeic oxygenation by nasal cannula during airway management in children undergoing general anaesthesia: a pilot randomised controlled trial

Background Airway management is a core clinical skill in anaesthesia. Pre-oxygenation prior to induction of anaesthesia is a standard practice to prevent desaturation. Apnoeic oxygenation in adults is effective and prolongs the time to desaturation. The effectiveness of apnoeic oxygenation in the adult is well documented; however, evidence in the paediatric is lacking. Therefore, the aim of this study was to investigate the effectiveness of apnoeic oxygenation during airway management in children. Methods This was a pilot randomised controlled trial. Patients were randomised to receive either apnoeic oxygenation or standard care during the induction of anaesthesia. The primary outcome was the duration of safe apnoea, defined as a composite of the time to first event, either time for SpO2 to drop to 92% or time to successfully secure the airway, and the lowest SpO2 observed during airway management. Secondary outcomes were the number of patients whose SpO2 dropped below 95% and the number of patients whose SpO2 dropped below 92%. Results A total of 30 patients were randomised, 15 to apnoeic oxygenation and 15 to standard care. No significant difference was observed in the time to first event (p = 0.870). However, patients randomised to apnoeic oxygenation had significantly higher SpO2 observed compared to the standard care group (p = 0.004). All patients in the apnoeic oxygenation group maintained SpO2 of 100% during airway management, compared to only six in the standard care group. SpO2 dropped below 92% in one patient, with the lowest SPO2 recorded 73%. Conclusion This study suggests that providing 3 l/min oxygen by nasal cannula following pre-oxygenation contributes to maintaining high levels of oxygen saturation during airway management in children, contributing to increased patients’ safety during general anaesthesia