J-Block Triassic Well Performance & Reservoir Heterogeneity

Imperial Users onl

INCORPORATING PRIVACY AND SECURITY FEATURES IN AN OPEN SOURCE SEARCH ENGINE A Project Report Presented to

The aim of this project was to explore and implement various privacy and security features in an open-source search engine and enhance the security and privacy capabilities of Yioop. Yioop, an open-source PHP search engine based on GPLv3 license, is designed and developed by Dr. Chris Pollett. We have enabled a crawl, search and index mechanism for hidden services by execution of codes, which has facilitated access of the Tor network in Yioop. We have diversified the ability of the previously supported text CAPTCHA functionality in Yioop by implementing hash CAPTCHA and provided feasibility to toggle between text CAPTCHA and hash CAPTCHA. To enable the user to log in to his or her respective Yioop account without sharing the password over the network, we have incorporated zero knowledge authentications in which Yioop does not store the user’s real password, but it stores the numerical password, which is derived from the user’s original password

An Experimental Study Exploring the Influence of Different Representation of Requirements on Idea Generation

This research aims to understand the influence of different representations of requirements on idea generation concerning the quantity, addressment, sketch detail, novelty, and variety of conceptual sketches. To solve design problems, engineers use the needs, desires, and wishes of stakeholders. The requirements document the targets of a project because it contains constraints and design criteria. Also, requirements can be used to track project progress. In essence, specifications are the raison d\u27être of any engineering project. While there is research studying the effect of requirements on the conceptual sketch, little study has focused on the impact of different requirement representations (contextual) on solution development. An experimental study was conducted with 52 undergraduate mechanical engineering students in their fourth year. Two design problems were formulated with three different representations: a problem statement with embedded requirements (Problem Statement), a problem statement and a traditional requirement list (Traditional), and a problem statement with contextualized scrum stories (Contextual). For each design problem, each student received different representations of requirements. They were given 15 minutes each to read and sketch concept solutions. These were then analyzed using quantity, addressment, sketch detail, novelty, and variety. It was found that the use of contextualized scrum story representations had a statistically significant impact on the conceptual sketch in terms of novelty of solution fragments and requirements addressed. Further, there was no significant change in variety, sketch detail, or quantity. The contextualized representation did positively affect all metrics but the sketch detail. Another finding was that there was no relationship between the amount of sketch generated (quantity) and addressment, novelty, variety, or sketch detail. Therefore, it is recommended that requirements be molded as scrum stories in projects. Also, this study has shown that implementation of the agile process in hardware development is not hindered by the contextual representation of requirements

Effectiveness of Virtual learning environments for teaching tooth morphology to dental students: a systematic review

To evaluate the effectiveness and acceptance of Virtual Learning Environments (VLEs) in teaching tooth morphology to dental students compared to conventional methods

Chymotrypsin Digestion Analysis to Characterize Site-Specific Incorporation of an Extrinsic Fluorescent Probe on a Ras-related Protein.

Ras Homolog Enriched in Brain (RHEB) is a member of Ras GTPase family and plays an important role in regulation of cell growth and cell cycle proliferation. RHEB is regulated by cycling between active (GTP-bound) and inactive (GDP-bound) state. Guanidine Nucleotide Exchange Factors (GEFs) and GTPase-activationg proteins (GAPs) are the key regulators of RHEB, and it is of interest to closely study their interactions with RHEB. Towards that end, this project was designed to label RHEB with an environmentally sensitive extrinsic fluorophore, succinimidyl 6-(N-(7-nitrobenz-2-oxa-1.3-diazol-4-yl)amino)hexanoate (sNBD), to be used to monitor RHEB-protein interactions. Due to its extreme sensitivity to the surrounding environment, sNBD is expected to show changes in fluorescence when labeled RHEB reacts with other protein effectors. Histidine tagged RHEB was expressed using E. coli bacteria as host cells and was purified using Histidine affinity column chromatography. Time-dependent chymotrypsin digestion experiments were performed in order to compare digestion patterns of RHEB and sNBD-labeled RHEB. Using the purified protein, RHEB-sNBD binding procedure was optimized. A modified purification procedure had to be designed in order to meet the buffer environment and concentration requirement for the RHEB-sNBD binding procedure. The RHEB-sNBD binding experiment was determined to work best with 1:24 molar ratio of RHEB to sNBD. Successful RHEB-sNBD binding was performed using PBS buffer as the solvent condition for protein, and DMF as the solvent for sNBD

Triad of Acute Pancreatitis Coexisting with Diabetic Ketoacidosis and Very Severe Hypertriglyceridemia Successfully Resolved with Insulin Therapy Alone

Diabetic ketoacidosis (DKA) is known to cause mild elevations in triglyceride levels. Severe hypertriglyceridemia (HTG) is a well-known cause of acute pancreatitis; however, in unique cases, DKA has been shown to cause severe HTG leading to the development of acute pancreatitis (AP). HTG causing AP only accounts for 1-4% of cases of AP From the few cases in literature that have reported this triad of DKA, HTG, and AP, even fewer have shown to be successfully treated with insulin therapy alone with the severe degree of HTG that we discuss. In our case, we have treated a triad of DKA, AP and severe HTG with a value of 16076 mg/dL with insulin therapy alone, which has not been documented in our literature search

Multiple Myeloma with Dual Expression of Kappa and Lambda Light Chains

Multiple myeloma (MM) is a malignancy of plasma cells that accounts for approximately 1 to 2 percent of all cancers and about 17% of all hematologic malignancies. Plasma cells normally produce antibodies and provide a defense mechanism for the body to fight infections. Antibodies typically consist of two heavy chains (IgG, IgA, IgM, IgD and IgE) and two light chains (kappa and lambda). Most cases of MM have malignant plasma cells producing monoclonal (M) proteins, most common being IgG about 52% of the time (1). Only about 2% of these myeloma cases were also found to secrete more than one paraprotein and classified as biclonal/biphenotypic plasma cell myeloma (2). Here we report a case of a woman who presented with lower back pain that was found to have biphenotypic multiple myeloma with a coexpression of kappa and lambda light chains