115 research outputs found
A fully resolved active musculo-mechanical model for esophageal transport
Esophageal transport is a physiological process that mechanically transports an ingested food bolus from the pharynx to the stomach via the esophagus, a multilayered muscular tube. This process involves interactions between the bolus, the esophagus, and the neurally coordinated activation of the esophageal muscles. In this work, we use an immersed boundary (IB) approach to simulate peristaltic transport in the esophagus. The bolus is treated as a viscous fluid that is actively transported by the muscular esophagus, and the esophagus is modeled as an actively contracting, fiber-reinforced tube. Before considering the full model of the esophagus, however, we first consider a standard benchmark problem of flow past a cylinder. Next a simplified version of our model is verified by comparison to an analytic solution to the tube dilation problem. Finally, three different complex models of the multi-layered esophagus, which differ in their activation patterns and the layouts of the mucosal layers, are extensively tested. To our knowledge, these simulations are the first of their kind to incorporate the bolus, the multi-layered esophagus tube, and muscle activation into an integrated model. Consistent with experimental observations, our simulations capture the pressure peak generated by the muscle activation pulse that travels along the bolus tail. These fully resolved simulations provide new insights into roles of the mucosal layers during bolus transport. In addition, the information on pressure and the kinematics of the esophageal wall resulting from the coordination of muscle activation is provided, which may help relate clinical data from manometry and ultrasound images to the underlying esophageal motor function
A moving control volume approach to computing hydrodynamic forces and torques on immersed bodies
We present a moving control volume (CV) approach to computing hydrodynamic
forces and torques on complex geometries. The method requires surface and
volumetric integrals over a simple and regular Cartesian box that moves with an
arbitrary velocity to enclose the body at all times. The moving box is aligned
with Cartesian grid faces, which makes the integral evaluation straightforward
in an immersed boundary (IB) framework. Discontinuous and noisy derivatives of
velocity and pressure at the fluid-structure interface are avoided and
far-field (smooth) velocity and pressure information is used. We re-visit the
approach to compute hydrodynamic forces and torques through force/torque
balance equation in a Lagrangian frame that some of us took in a prior work
(Bhalla et al., J Comp Phys, 2013). We prove the equivalence of the two
approaches for IB methods, thanks to the use of Peskin's delta functions. Both
approaches are able to suppress spurious force oscillations and are in
excellent agreement, as expected theoretically. Test cases ranging from Stokes
to high Reynolds number regimes are considered. We discuss regridding issues
for the moving CV method in an adaptive mesh refinement (AMR) context. The
proposed moving CV method is not limited to a specific IB method and can also
be used, for example, with embedded boundary methods
- …