The applications of infrared thermography in surgical removal of retained teeth effects assessment

during filling cavities, laser treatment and inflammation of periodontal tissues. The biggest problem in thermal imaging was limiting access and rapid change of humidity when the mouth opens during measurements. However, nowadays thermal map of body surface is correlated with inflammatory state changing inner mouth. The aim of this study was to assess the suitability of thermal imaging to localize the inflammation and monitor treatment effects after surgical removal of third retained molar teeth. The cohort consisted of 27 patients with referral for the surgical extraction of the third retained molar. Thermal imaging of the sagittal face was performed before and after the procedure and on the first, fourth and seventh day after the extraction. Obtained thermal maps are correlated with the third molar teeth inflammation location. Moreover, the changes of temperature in the area of both the tooth and the cheek correspond to the mechanisms of wound healing described in the literature. Obtained results were not only qualitative but also quantitative what was confirmed by statistically significant difference. It seems that thermal imaging, which is a noninvasive method, can be used to monitor treatment processes after surgical procedures, as well as on the location of inflammation

Angiogenesis Markers Quantification in Breast Cancer and Their Correlation with Clinicopathological Prognostic Variables

Tumoural angiogenesis is essential for the growth and spread of breast cancer cells. Therefore the aim of this study was to assess the diagnostic performance of angiogenesis markers in tumours and there reflecting levels in serum of breast cancer patients. Angiogenin, Ang2, fibroblast growth factor basic, intercellular adhesion molecule (ICAM)-1, keratinocyte growth factor (KGF), platelet-derived growth factor-BB, and VEGF-A were measured using a FASTQuant angiogenic growth factor multiplex protein assay. We observed that breast cancer tumours exhibited high levels of PDGF-BB, bFGF and VEGF, and extremely high levels of TIMP-1 and Ang-2, whereas in serum we found significantly higher levels of Ang-2, PDGF-BB, bFGF, ICAM-1 and VEGF in patients with breast cancer compared to the benign breast diseases patients. Moreover, some of these angiogenesis markers evaluated in tumour and serum of breast cancer patients exhibited association with standard clinical parameters, ER status as well as MVD of tumours. Angiogenesis markers play important roles in tumour growth, invasion and metastasis. Our results suggest that analysis of angiogenesis markers in tumour and serum of breast cancer patients using multiplex protein assay can improve diagnosis and prognosis in this diseases