451 research outputs found
Metal-nanoparticle single-electron transistors fabricated using electromigration
We have fabricated single-electron transistors from individual metal
nanoparticles using a geometry that provides improved coupling between the
particle and the gate electrode. This is accomplished by incorporating a
nanoparticle into a gap created between two electrodes using electromigration,
all on top of an oxidized aluminum gate. We achieve sufficient gate coupling to
access more than ten charge states of individual gold nanoparticles (5-15 nm in
diameter). The devices are sufficiently stable to permit spectroscopic studies
of the electron-in-a-box level spectra within the nanoparticle as its charge
state is varied.Comment: 3 pages, 3 figures, submitted to AP
From ballistic transport to tunneling in electromigrated ferromagnetic breakjunctions
We fabricate ferromagnetic nanowires with constrictions whose cross section
can be reduced gradually from 100 nm to the atomic scale and eventually to the
tunneling regime by means of electromigration. These devices are mechanically
stable against magnetostriction and magnetostatic effects. We measure
magnetoresistances ~ 0.3% for 100*30 nm^2 constrictions, increasing to a
maximum of 80% for atomic-scale widths. These results are consistent with a
geometrically-constrained domain wall trapped at the constriction. For the
devices in the tunneling regime we observe large fluctuations in MR, between
-10 and 85%.Comment: 4 pages, 5 figure
Qualitative and Quantitative Detection of Chlamydophila pneumoniae DNA in Cerebrospinal Fluid from Multiple Sclerosis Patients and Controls
A standardized molecular test for the detection of Chlamydophila pneumoniae DNA in cerebrospinal fluid (CSF) would assist the further assessment of the association of C. pneumoniae with multiple sclerosis (MS). We developed and validated a qualitative colorimetric microtiter plate-based PCR assay (PCR-EIA) and a real-time quantitative PCR assay (TaqMan) for detection of C. pneumoniae DNA in CSF specimens from MS patients and controls. Compared to a touchdown nested-PCR assay, the sensitivity, specificity, and concordance of the PCR-EIA assay were 88.5%, 93.2%, and 90.5%, respectively, on a total of 137 CSF specimens. PCR-EIA presented a significantly higher sensitivity in MS patients (p = 0.008) and a higher specificity in other neurological diseases (p = 0.018). Test reproducibility of the PCR-EIA assay was statistically related to the volumes of extract DNA included in the test (p = 0.033); a high volume, which was equivalent to 100 µl of CSF per reaction, yielded a concordance of 96.8% between two medical technologists running the test at different times. The TaqMan quantitative PCR assay detected 26 of 63 (41.3%) of positive CSF specimens that tested positive by both PCR-EIA and nested-PCR qualitative assays. None of the CSF specimens that were negative by the two qualitative PCR methods were detected by the TaqMan quantitative PCR. The PCR-EIA assay detected a minimum of 25 copies/ml C. pneumoniae DNA in plasmid-spiked CSF, which was at least 10 times more sensitive than TaqMan. These data indicated that the PCR-EIA assay possessed a sensitivity that was equal to the nested-PCR procedures for the detection of C. pneumoniae DNA in CSF. The TaqMan system may not be sensitive enough for diagnostic purposes due to the low C. pneumoniae copies existing in the majority of CSF specimens from MS patients
Mechanically-adjustable and electrically-gated single-molecule transistors
We demonstrate a device geometry for single-molecule electronics experiments
that combines both the ability to adjust the spacing between the electrodes
mechanically and the ability to shift the energy levels in the molecule using a
gate electrode. With the independent in-situ variations of molecular properties
provided by these two experimental "knobs", we are able to achieve a much more
detailed characterization of electron transport through the molecule than is
possible with either technique separately. We illustrate the devices'
performance using C60 molecules.Comment: 15 pages, 3 figure
Extreme Sensitivity of the Superconducting State in Thin Films
All non-interacting two-dimensional electronic systems are expected to
exhibit an insulating ground state. This conspicuous absence of the metallic
phase has been challenged only in the case of low-disorder, low density,
semiconducting systems where strong interactions dominate the electronic state.
Unexpectedly, over the last two decades, there have been multiple reports on
the observation of a state with metallic characteristics on a variety of
thin-film superconductors. To date, no theoretical explanation has been able to
fully capture the existence of such a state for the large variety of
superconductors exhibiting it. Here we show that for two very different
thin-film superconductors, amorphous indium-oxide and a single-crystal of
2H-NbSe2, this metallic state can be eliminated by filtering external
radiation. Our results show that these superconducting films are extremely
sensitive to external perturbations leading to the suppression of
superconductivity and the appearance of temperature independent, metallic like,
transport at low temperatures. We relate the extreme sensitivity to the
theoretical observation that, in two-dimensions, superconductivity is only
marginally stable.Comment: 10 pages, 6 figure
Study protocol. A prospective cohort study of unselected primiparous women: the pregnancy outcome prediction study.
BACKGROUND: There have been dramatic changes in the approach to screening for aneuploidy over the last 20 years. However, the approach to screening for other complications of pregnancy such as intra-uterine growth restriction, pre-eclampsia and stillbirth remains largely unchanged. Randomised controlled trials of routine application of high tech screening methods to the general population have generally failed to show improvement in outcome. We have previously reviewed this and concluded it was due, in large part, to poor performance of screening tests. Here, we report a study design where the primary aim is to generate clinically useful methods to screen women to assess their risk of adverse pregnancy outcome. METHODS/DESIGN: We report the design of a prospective cohort study of unselected primiparous women recruited at the time of their first ultrasound scan. Participation involves serial phlebotomy and obstetric ultrasound at the dating ultrasound scan (typically 10-14 weeks), 20 weeks, 28 weeks and 36 weeks gestation. In addition, maternal demographic details are obtained; maternal and paternal height are measured and maternal weight is serially measured during the pregnancy; maternal, paternal and offspring DNA are collected; and, samples of placenta and membranes are collected at birth. Data will be analysed as a prospective cohort study, a case-cohort study, and a nested case-control study. DISCUSSION: The study is expected to provide a resource for the identification of novel biomarkers for adverse pregnancy outcome and to evaluate the performance of biomarkers and serial ultrasonography in providing clinically useful prediction of risk
Compulsive versifying after treatment of transient epileptic amnesia
Compulsive production of verse is an unusual form of hypergraphia that has been reported mainly in patients with right temporal lobe seizures. We present a patient with transient epileptic amnesia and a left temporal seizure focus, who developed isolated compulsive versifying, producing multiple rhyming poems, following seizure cessation induced by lamotrigine. Functional neuroimaging studies in the healthy brain implicate left frontotemporal areas in generating novel verbal output and rhyme, while dysregulation of neocortical and limbic regions occurs in temporal lobe epilepsy. This case complements previous observations of emergence of altered behavior with reduced seizure frequency in patients with temporal lobe epilepsy. Such cases suggest that reduced seizure frequency has the potential not only to stabilize or improve memory function, but also to trigger complex, specific behavioral alterations
Hundredfold Enhancement of Light Emission via Defect Control in Monolayer Transition-Metal Dichalcogenides
Two dimensional (2D) transition-metal dichalcogenide (TMD) based
semiconductors have generated intense recent interest due to their novel
optical and electronic properties, and potential for applications. In this
work, we characterize the atomic and electronic nature of intrinsic point
defects found in single crystals of these materials synthesized by two
different methods - chemical vapor transport and self-flux growth. Using a
combination of scanning tunneling microscopy (STM) and scanning transmission
electron microscopy (STEM), we show that the two major intrinsic defects in
these materials are metal vacancies and chalcogen antisites. We show that by
control of the synthetic conditions, we can reduce the defect concentration
from above to below . Because these point
defects act as centers for non-radiative recombination of excitons, this
improvement in material quality leads to a hundred-fold increase in the
radiative recombination efficiency
Magnetism in Semiconducting Molybdenum Dichalcogenides
Transition metal dichalcogenides (TMDs) are interesting for understanding
fundamental physics of two-dimensional materials (2D) as well as for many
emerging technologies, including spin electronics. Here, we report the
discovery of long-range magnetic order below TM = 40 K and 100 K in bulk
semiconducting TMDs 2H-MoTe2 and 2H-MoSe2, respectively, by means of muon
spin-rotation (muSR), scanning tunneling microscopy (STM), as well as density
functional theory (DFT) calculations. The muon spin rotation measurements show
the presence of a large and homogeneous internal magnetic fields at low
temperatures in both compounds indicative of long-range magnetic order. DFT
calculations show that this magnetism is promoted by the presence of defects in
the crystal. The STM measurements show that the vast majority of defects in
these materials are metal vacancies and chalcogen-metal antisites which are
randomly distributed in the lattice at the sub-percent level. DFT indicates
that the antisite defects are magnetic with a magnetic moment in the range of
0.9-2.8 mu_B. Further, we find that the magnetic order stabilized in 2H-MoTe2
and 2H-MoSe2 is highly sensitive to hydrostatic pressure. These observations
establish 2H-MoTe2 and 2H-MoSe2 as a new class of magnetic semiconductors and
opens a path to studying the interplay of 2D physics and magnetism in these
interesting semiconductors.Comment: 13 pages, 10 Figure
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