10 research outputs found
Positivity of HIV, hepatitis B and hepatitis C in patients enrolled in a confidential self-exclusion system of blood donation: a cross-sectional analytical study
Policaptil Gel RetardÂŽ significantly reduces body mass index and hyperinsulinism and may decrease the risk of type 2 diabetes mellitus (T2DM) in obese children and adolescents with family history of obesity and T2DM
BACKGROUND: Treatments for childhood obesity are critically needed because of the risk of developing co-morbidities, although the interventions are frequently time-consuming, frustrating, difficult, and expensive. PATIENTS AND METHODS: We conducted a longitudinal, randomised, clinical study, based on a per protocol analysis, on 133 obese children and adolescents (nâ=â69 males and 64 females; median age, 11.3Â years) with family history of obesity and type 2 diabetes mellitus (T2DM). The patients were divided into three arms: Arm A (nâ=â53 patients), Arm B (nâ=â45 patients), and Arm C (nâ=â35 patients) patients were treated with a low-glycaemic-index (LGI) diet and Policaptil Gel RetardÂŽ, only a LGI diet, or only an energy-restricted diet (ERD), respectively. The homeostasis model assessment of insulin resistance (HOMA-IR) and the Matsuda, insulinogenic and disposition indexes were calculated at T(0) and after 1Â year (T(1)). RESULTS: At T(1), the BMI-SD scores were significantly reduced from 2.32 to 1.80 (pâ<â0.0001) in Arm A and from 2.23 to 1.99 (pâ<â0.05) in Arm B. Acanthosis nigricans was significantly reduced in Arm A (13.2% to 5.6%; pâ<â0.05), and glycosylated-haemoglobin levels were significantly reduced in Arms A (pâ<â0.005). The percentage of glucose-metabolism abnormalities was reduced, although not significantly. However, the HOMA-IR index was significantly reduced in Arms A (pâ<â0.0001) and B (pâ<â0.05), with Arm A showing a significant reduction in the insulinogenic index (pâ<â0.05). Finally, the disposition index was significantly improved in Arms A (pâ<â0.0001) and B (pâ<â0.05). CONCLUSIONS: A LGI diet, particularly associated with the use of Policaptil Gel RetardÂŽ, may reduce weight gain and ameliorate the metabolic syndrome and insulin-resistance parameters in obese children and adolescents with family history of obesity and T2DM
Experimantal determination of the optimal feed mass in a fluidized bed jet mill
Celem badaĹ byĹo okreĹĹenie optymaĹnej masy poczÄ
tkowej nadawy, zapewniajÄ
cej uzyskanie najdrobniejszego produktu w Ĺaboratoryj-nym mĹynie strumieniowo-fluidalnym. Badaniom poddano prĂłbki kamienia wapiennego o uziarnieniu 800-1200 um. Metodyka badaĹ obejmowaĹa przeprowadzenie prĂłb rozdrabniania oraz pomiary skĹadu ziarnowego nadawy i produktĂłw mielenia.The paper deals with an influence of initial feed mass on comminution process outcome in a taboratory fluidized bed opposed jet mii!. Sam-p]es of timestone partictes of size ranging from 0.8 to l .2 mm were sub-jected to testing. Research methodology comprised the fottowing sta-ges: grinding tests, determination of particte size distribution of feed material and mitting products
Low frequency of HLA-DRB1*11 in hepatitis C virus induced end stage liver disease
Hepatitis C virus (HCV) infection becomes chronic in more than 70% of patients, leading to end stage liver disease in about 20-30% of these patients. Apart from the virus itself, host factors that modulate the immune response are likely to be involved in determining the outcome of HCV infection. Studies on the association of human leucocyte antigens (HLAs) and HCV infection have shown inconsistent results. Selection of patient subgroups may be crucial. However, any association relevant to HCV disease progression will become evident, especially in those patients with end stage liver disease. Therefore, we analysed the phenotype frequencies of HLA antigens in two groups of 69 and 39 patients with HCV induced liver cirrhosis who had received a transplant or were awaiting liver transplantation. The first group was typed serologically and compared with 331 blood and liver donors. The second group, prospectively HLA typed by a polymerase chain reaction-sequence specific oligonucleotide (PCR-SSO) procedure for HLA-DRB and DQB alleles, was compared with another 170 PCR-SSO typed and randomly selected blood donors. Decreased frequencies for HLA-DR5 and HLA-DQ3 were found in one group of patients with HCV induced liver cirrhosis compared with the control groups. In the second analysis comparing 39 patients with end stage liver cirrhosis with blood donors, we confirmed the significant decrease in HLA-DRB1*11 and HLA-DQB1*03, which corresponded to serological HLA-DR5 and HLA-DQ3 antigens, respectively. Our results show that the presence of HLA-DRB1*11 and HLA-DQB1*03 alleles is associated with a reduced risk for the development of HCV induced end stage liver disease.â¨â¨â¨Keywords: hepatitis C; HLA; liver cirrhosis; immunogenetics; hepatocellular carcinoma; genotyp