421 research outputs found

    High frequency GaAs nano-optomechanical disk resonator

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    Optomechanical coupling between a mechanical oscillator and light trapped in a cavity increases when the coupling takes place in a reduced volume. Here we demonstrate a GaAs semiconductor optomechanical disk system where both optical and mechanical energy can be confined in a sub-micron scale interaction volume. We observe giant optomechanical coupling rate up to 100 GHz/nm involving picogram mass mechanical modes with frequency between 100 MHz and 1 GHz. The mechanical modes are singled-out measuring their dispersion as a function of disk geometry. Their Brownian motion is optically resolved with a sensitivity of 10^(-17)m/sqrt(Hz) at room temperature and pressure, approaching the quantum limit imprecision.Comment: 7 pages, 3 figure

    Effect of creatine supplementation on the airways of youth elite soccer players

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    Introduction Owing to its well-established ergogenic potential, creatine is a highly popular food supplement in sports. As an oral supplement, creatine is considered safe and ethical. However, no data exist on the safety of creatine on lung function in athletes. The aim of this project was to evaluate the effects of a standard course of creatine on the airways of youth elite athletes. Methods Nineteen elite soccer players, 16-21 yr old, completed a stratified, randomized, double-blind, placebo-controlled, parallel-group trial. The creatine group (n = 9) ingested 0.3 gĀ·kg-1ā‹…d-1 of creatine monohydrate (CM) for 1 wk (loading phase) and 5 gĀ·d-1 for 7 wk (maintenance phase), and the placebo group (n = 10) received the same dosages of maltodextrin. Airway inflammation (assessed by exhaled nitric oxide, FENO) and airway responsiveness (to dry air hyperpnoea) were measured pre- and postsupplementation. Results Mild, unfavorable changes in FENO were noticed by trend over the supplementation period in the CM group only (P = 0.056 for interaction, Ī·2 = 0.199), with a mean group change of 9 Ā± 13 ppb in the CM group versus -5 Ā± 16 ppb in the placebo group (P = 0.056, d = 0.695). Further, the maximum fall in forced expiratory volume in 1 s after dry air hyperpnoea was larger by trend postsupplementation in the CM group compared with the placebo group: 9.7% Ā± 7.5% vs 4.4% Ā± 1.4%, respectively (P = 0.070, d = 0.975). These adverse effects were more pronounced when atopic players only (n = 15) were considered. Conclusion On the basis of the observed trends and medium to large effect sizes, we cannot exclude that creatine supplementation has an adverse effect on the airways of elite athletes, particularly in those with allergic sensitization. Further safety profiling of the ergogenic food supplement is warranted

    Understanding the integration of artificial intelligence in healthcare organisations and systems through the NASSS framework: a qualitative study in a leading Canadian academic centre

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    Background: Artificial intelligence (AI) technologies are expected to ā€œrevolutioniseā€ healthcare. However, despite their promises, their integration within healthcare organisations and systems remains limited. The objective of this study is to explore and understand the systemic challenges and implications of their integration in a leading Canadian academic hospital. Methods: Semi-structured interviews were conducted with 29 stakeholders concerned by the integration of a large set of AI technologies within the organisation (e.g., managers, clinicians, researchers, patients, technology providers). Data were collected and analysed using the Non-Adoption, Abandonment, Scale-up, Spread, Sustainability (NASSS) framework. Results: Among enabling factors and conditions, our findings highlight: a supportive organisational culture and leadership leading to a coherent organisational innovation narrative; mutual trust and transparent communication between senior management and frontline teams; the presence of champions, translators, and boundary spanners for AI able to build bridges and trust; and the capacity to attract technical and clinical talents and expertise. Constraints and barriers include: contrasting definitions of the value of AI technologies and ways to measure such value; lack of real-life and context-based evidence; varying patientsā€™ digital and health literacy capacities; misalignments between organisational dynamics, clinical and administrative processes, infrastructures, and AI technologies; lack of funding mechanisms covering the implementation, adaptation, and expertise required; challenges arising from practice change, new expertise development, and professional identities; lack of official professional, reimbursement, and insurance guidelines; lack of pre- and post-market approval legal and governance frameworks; diversity of the business and financing models for AI technologies; and misalignments between investorsā€™ priorities and the needs and expectations of healthcare organisations and systems. Conclusion: Thanks to the multidimensional NASSS framework, this study provides original insights and a detailed learning base for analysing AI technologies in healthcare from a thorough socio-technical perspective. Our findings highlight the importance of considering the complexity characterising healthcare organisations and systems in current efforts to introduce AI technologies within clinical routines. This study adds to the existing literature and can inform decision-making towards a judicious, responsible, and sustainable integration of these technologies in healthcare organisations and systems

    Wavelength-sized GaAs optomechanical resonators with GHz frequency

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    We report on wavelength-sized GaAs optomechanical disk resonators showing ultra-strong optomechanical interaction. We observe optical transduction of a disk mechanical breathing mode with 1.4 GHz frequency and effective mass of ~ 2 pg. The measured vacuum optomechanical coupling rate reaches 0.8 MHz, with a related differential optomechanical coupling factor of 485 GHz/nm. The disk Brownian motion is optically resolved with a sensitivity of 10-17 m/{\sqrt}Hz at room temperature and pressure.Comment: 8 pages, 3 figure

    Self-reference and emotional reaction drive aesthetic judgment

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    Traditional philosophical inquiry, and more recently neuroscientific studies, have investigated the sources of artworks' aesthetic appeal. A substantial effort has been made to isolate the objective features contributing to aesthetic appreciation. While variables such as contrast or symmetry have been shown to robustly impact aesthetic judgment, they only account for a small portion of the intersubjective variability in aesthetic ratings. Recent multiprocess model of aesthetic appreciation could accommodate this finding by proposing that evaluative processes based on self-reference underpin the idiosyncrasy of aesthetic judgment. We tested this hypothesis in two behavioral studies, that were basically conceptual replications of our previous work, in which we took advantage of the self-reference effect on memory. We also tried to disentangle the role of self-reference and emotional reaction to artworks in guiding aesthetic judgments, by comparing an aesthetic judgment encoding condition to a self-reference condition (Study 1), and an emotional evaluation condition (Study 2). We show that artworks encoded in an aesthetic judgment condition exhibit a similar mnesic advantage compared to both the self-reference and the emotional evaluation encoding conditions. Moreover, retrospective emotional judgment correlates with both self-reference and aesthetic judgments ratings. These results suggest that a basic mechanism, appraisal of self-relevance, could ground aesthetic judgments

    Consultation on How to Implement Canada\u27s CUSMA Commitment to Extend the General Term of Copyright Protection

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    As a group of Canadian Intellectual Property Law scholars, we write regarding the Ministersā€™ recently launched consultation on extending the term of copyright protection in order to meet Canadaā€™s CUSMA commitments. With this letter, which we jointly submit in response to the call for comments, we wish to express our shared concerns about both the proposed term extension and, more immediately, the inappropriately curtailed nature of this consultation process
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