Concordance between ASH grades presumed by AshTest and by biopsy.

<p>The histological score is the sum of the 3 elementary lesion grades: Ballooning, PMN and Mallory bodies.</p><p>Concordance between ASH grades presumed by AshTest and by biopsy.</p

Comparison between included and non-included patients.

<p>¹One FibroTest was not reliable, and all AshTest were reliable</p><p>Comparison between included and non-included patients.</p

Flow chart of inclusion.

<p>Flow chart of inclusion.</p

Performance of AshTest for the diagnosis (binary) and severity (ordinal) of alcoholic steatohepatitis (n = 123).

<p>AshTest had significant higher AUROCs than AST/ALT for all scores and lesions. NonBinROC is the Obuchowski measure, the non-binary estimate of ordinal test performance. AshTest had significant Obuchowski measures than AST/ALT for ASH scores and for PMN and Mallory.</p><p>Performance of AshTest for the diagnosis (binary) and severity (ordinal) of alcoholic steatohepatitis (n = 123).</p

Area under the ROC curves (AUROC) of AshTest versus AST/ALT, Maddrey, and MELD scores.

<p>0.815 (0.639–0.910), 0.565 (0.348–0.725), 0.571 (0.448–0.730) and 0.537 (0.327–0.751) respectively, for the diagnosis of at least one histological features of alcoholic hepatitis. All comparisons were significant (P<0.01) between AshTest and AST/ALT, Maddrey and MELD scores.</p

Comparison of Area under the Receiver Operating Characteristics Curves (AUROC) for survival endpoints, between FibroTest, ActiTest, ALT, viral load, Pugh score and APRI index. N = 978.

f<p>FibroTest AUROC greater than that with ActiTest (p = 0.001), ALT (p<0.001), Viral Load (p<0.001), Pugh classification (p = 0.0025), APRI Index (p<0.001).</p>g<p>FibroTest AUROC greater than that with ActiTest (p = 0.0016), ALT (p<0.001), Viral Load (p<0.001), Pugh classification (p = 0.005), APRI Index (p<0.001).</p>h<p>FibroTest AUROC greater than that with ActiTest (p<0.001), ALT (p<0.001), Viral Load (p<0.001), Pugh classification (p = 0.002), APRI Index (p<0.001).</p

Survival according to definition of inactive carrier based on FibroTest-ActiTest normal values in untreated patients.

*<p>Both normal values: FibroTest < = 0.27 and ActiTest < = 0.29.</p>**<p>Survivals of patients with abnormal FibroTest and ActiTest were lower than those of normal FibroTest and ActiTest (p<0.005).</p>***<p>Survivals of patients with or without one coinfection (HVI, HCV, Delta) were not significantly different (p>0.05).</p>****<p>Overall survivals of patients with abnormal FibroTest and ActiTest were lower to those in paired controls (p<0.005).</p>$<p>Inactive carrier: anti HBe, normal ALT, viral load <2,000 IU/ml, no coinfection HCV, HIV, or Delta.</p

Comparison of Area under the Receiver Operating Characteristics Curves (AUROC) for survival endpoints, between FibroTest and simultaneous histology. N = 97.

a<p>FibroTest AUROC was similar to that with fibrosis staging.</p>b<p>NP, not performed because the number of events was too low.</p

Prognostic factors associated with survival without HBV complications or death in 1074 patients.

<p>Prognostic factors associated with survival without HBV complications or death in 1074 patients.</p

Characteristics of included patients.

<p>NP = Not performed.</p