Initiation and propagation mechanisms of progressive crushing in carbon-epoxy laminated plates

This article presents original experiments that enhance the understanding of the mechanisms that drive the progressive crushing of fiber-reinforced laminated composite materials and their energy absorption capability. An innovative experimental fixture has been created in order to obtain detailed monitoring of quasi-static and dynamic crushing of laminated plates. The fixture enables the development of a regular crushing front through the whole width of the plate, without parasite rupture modes, and the real-time observation of this front with a high speed camera. Results of experimental works on fabric and unidirectional Carbon-Epoxy laminated composite plates are exposed. The obtained crushing modes are analysed, their stability and energy-absorbing capability are discussed

Experimental and numerical study of the splaying mode crush of CFRP laminates

Thanks to an innovative plate crushing test fixture, elementary crushing modes of CFRP laminates have been observed and analysed for static and dynamic loading. These analyses enabled to propose a 2D explicit finite element model at mesoscale for the simulation of splaying mode, with a good correlation between model and test data

Développement d'un modèle de l'écrasement progressif des composites stratifiés en dynamique

Grâce à un dispositif d'essai original d'écrasement de plaques composites, des modes d’écrasement élémentaires de stratifiés CFRP ont été observés et analysés pour des chargements statiques et dynamiques. Ces analyses ont permis de proposer un modèle éléments finis 2D explicite, avec modélisation de l'endommagement du matériau à l'échelle mésoscopique, pour la simulation du mode d’écrasement par évasement, avec une bonne corrélation entre modèle et expérience

Reference-less complex wavefields characterization with a high-resolution wavefront sensor

Wavefront sensing is a widely-used non-interferometric, single-shot, and quantitative technique providing the spatial-phase of a beam. The phase is obtained by integrating the measured wavefront gradient. Complex and random wavefields intrinsically contain a high density of singular phase structures (optical vortices) associated with non-conservative gradients making this integration step especially delicate. Here, using a high-resolution wavefront sensor, we demonstrate experimentally a systematic approach for achieving the complete and quantitative reconstruction of complex wavefronts. Based on the Stokes' theorem, we propose an image segmentation algorithm to provide an accurate determination of the charge and location of optical vortices. This technique is expected to benefit to several fields requiring complex media characterization.Comment: 7 page

Provins – Église et cimetière Saint-Ayoul

La campagne de fouille de l’église Saint-Ayoul et de son cimetière, dans la ville basse de Provins, s’est déroulée du 27 juillet au 5 septembre 1997 ; il s’agit de la première campagne de fouille programmée, après un diagnostic-évaluation, en août 1996, qui avait permis de préciser nos objectifs principaux et de confirmer les potentialités archéologiques du site. Notre intervention poursuit une double perspective, scientifique (archéo-anthropologie plaçant au premier plan l’interprétation de..

Post cardiac surgery vasoplegia is associated with high preoperative copeptin plasma concentration

International audienceABSTRACT: INTRODUCTION: Post cardiac surgery vasodilatation is possibly related to a vasopressin deficiency that could be related to a chronic stimulation of the adeno-hypophysis. To assess vasopressin system activation, perioperative course of copeptin and vasopressin plasma concentrations have been studied in consecutive patients operated on cardiac surgery. METHODS: 64 consecutive patients scheduled for elective cardiac surgery with cardiopulmonary bypass were studied. Haemodynamic, laboratory and clinical data were recorded before and during cardiopulmonary bypass, and at the 8th post-operative hour (H8). At the same time, point's blood was withdrawn to determine plasma concentrations of arginine-vasopressin (AVP, radioimmunoassay) and copeptin (immunoluminometric assay). Post cardiac surgery vasodilation (PCSV) was defined as a mean arterial blood pressure less than 60 mmHg with a cardiac index [equal to or greater than] 2.2 L * min^-1 * m^-2, and was treated with norepinephrine (NE) in order to restore a mean blood pressure > 60 mmHg. Patients with PCSV were compared to the other patients (controls). Student's t, Fisher's exact test, or non parametric tests (Mann Whitney, Wilkoxon) were used when appropriate. A correlation between AVP and copeptin has been evaluated and a receiver-operator characteristic (ROC) analysis was calculated to assess the utility of preoperative copeptin to distinguish between controls and PCSV patients. RESULTS: Patients who experienced a PCSV have significantly higher copeptin plasma concentration before cardiopulmonary bypass (P <0.001) but lower AVP concentrations at H8 (P <0.01) than controls. PCSV patients had preoperative hyponatremia and decreased left ventricle ejection fraction, and experienced more complex surgery (redo). The area under the ROC curve of preoperative copeptin concentration was 0.86[plus/minus]0.04 [95%CI: 0.78-0.94] (P <0.001). The best predictive value for preoperative copeptin plasma concentration was 9.43 pmol/L with a sensitivity of 90% and a specificity of 77%. CONCLUSIONS: High preoperative copeptin plasma concentration is predictive of PSCV and suggests an activation of the AVP system before surgery that may facilitate depletion of endogenous AVP stores and a relative AVP deficit after surgery

Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study

Background: Adrenomedullin (ADM) regulates vascular tone and endothelial permeability during sepsis. Levels of circulating biologically active ADM (bio-ADM) show an inverse relationship with blood pressure and a direct relationship with vasopressor requirement. In the present prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock 1 (, AdrenOSS-1) study, we assessed relationships between circulating bio-ADM during the initial intensive care unit (ICU) stay and short-term outcome in order to eventually design a biomarker-guided randomized controlled trial. Methods: AdrenOSS-1 was a prospective observational multinational study. The primary outcome was 28-day mortality. Secondary outcomes included organ failure as defined by Sequential Organ Failure Assessment (SOFA) score, organ support with focus on vasopressor/inotropic use, and need for renal replacement therapy. AdrenOSS-1 included 583 patients admitted to the ICU with sepsis or septic shock. Results: Circulating bio-ADM levels were measured upon admission and at day 2. Median bio-ADM concentration upon admission was 80.5 pg/ml [IQR 41.5-148.1 pg/ml]. Initial SOFA score was 7 [IQR 5-10], and 28-day mortality was 22%. We found marked associations between bio-ADM upon admission and 28-day mortality (unadjusted standardized HR 2.3 [CI 1.9-2.9]; adjusted HR 1.6 [CI 1.1-2.5]) and between bio-ADM levels and SOFA score (p &lt; 0.0001). Need of vasopressor/inotrope, renal replacement therapy, and positive fluid balance were more prevalent in patients with a bio-ADM &gt; 70 pg/ml upon admission than in those with bio-ADM ≤ 70 pg/ml. In patients with bio-ADM &gt; 70 pg/ml upon admission, decrease in bio-ADM below 70 pg/ml at day 2 was associated with recovery of organ function at day 7 and better 28-day outcome (9.5% mortality). By contrast, persistently elevated bio-ADM at day 2 was associated with prolonged organ dysfunction and high 28-day mortality (38.1% mortality, HR 4.9, 95% CI 2.5-9.8). Conclusions: AdrenOSS-1 shows that early levels and rapid changes in bio-ADM estimate short-term outcome in sepsis and septic shock. These data are the backbone of the design of the biomarker-guided AdrenOSS-2 trial. Trial registration: ClinicalTrials.gov, NCT02393781. Registered on March 19, 2015

Undecidable word problem in subshift automorphism groups

International audienceThis article studies the complexity of the word problem in groups of automorphisms of subshifts. We show in particular that for any Turing degree, there exists a subshift whose automorphism group contains a subgroup whose word problem has exactly this degree