20 research outputs found
Allylic Carbon–Carbon Double Bond Directed Pd-Catalyzed Oxidative <i>ortho</i>-Olefination of Arenes
Pd-catalyzed selective <i>ortho</i>-olefination
of arenes
assisted by an allylic C–C double bond at room temperature
using O<sub>2</sub> as a terminal oxidant is described. A possible
mechanism involving the initial coordination of allylic Cî—»C
bond to Pd followed by selective <i>o</i>-C–H bond
metalation is proposed
Pd-Catalyzed π‑Chelation Assisted <i>ortho</i>-C–H Activation and Annulation of Allylarenes with Internal Alkynes
The synthesis of highly substituted naphthalenes from allylarenes and alkynes is described. This reaction proceeds via π-coordination of an allylic carbon–carbon double bond to the Pd(II) center and is followed by <i>ortho</i> selective C–H bond activation
Allylic Carbon–Carbon Double Bond Directed Pd-Catalyzed Oxidative <i>ortho</i>-Olefination of Arenes
Pd-catalyzed selective <i>ortho</i>-olefination
of arenes
assisted by an allylic C–C double bond at room temperature
using O<sub>2</sub> as a terminal oxidant is described. A possible
mechanism involving the initial coordination of allylic Cî—»C
bond to Pd followed by selective <i>o</i>-C–H bond
metalation is proposed
Expedient C–H Chalcogenation of Indolines and Indoles by Positional-Selective Copper Catalysis
A versatile protocol for the C–H
chalcogenation of indolines
and indoles by means of copper catalysis was established. The C–H
functionalization occurred selectively at the C7 position of indolines
and exclusively at the C(2)–H bonds of indoles. The robust
copper catalyst tolerated a wide range of functional groups and set
the stage for the synthesis of diversely decorated indoles. Mechanistic
studies were indicative of a SET-type mechanism and a facile C–H
metalation being operative
Palladium-Catalyzed Dehydrogenative β‑Arylation of Simple Saturated Carbonyls by Aryl Halides
A versatile
palladium-catalyzed synthesis of highly substituted α,β-unsaturated
carbonyl compounds has been developed. In contrast to the known Heck-type
coupling reaction of unsaturated carbonyl compounds with aryl halides,
the present methodology allows the use of stable and readily available
saturated carbonyl compounds as the alkene source. In addition, the
reaction proceeds well with low catalyst loadings and does not require
any expensive metal oxidants or ligands. A variety of saturated aldehydes,
ketones, and esters are compatible for the reaction with aryl halides
under the developed reaction conditions to afford α,β-unsaturated
carbonyl compounds in good to excellent yields. A possible reaction
mechanism involves a palladium-catalyzed dehydrogenation followed
by Heck-type cross couplings
Ruthenium-Catalyzed C–H Alkynylation of Aromatic Amides with Hypervalent Iodine–Alkyne Reagents
An
efficient C–H activation method for the <i>ortho</i> alkynylation of aromatic <i>N-</i>methoxyamides with hypervalent
iodine–alkyne reagent using a ruthenium catalyst is described.
The reaction proceeds under mild reaction conditions with broad substrate
scope. A possible catalytic cycle involving a ruthenium carboxylate
assisted C–H bond cleavage is proposed from the preliminary
mechanistic evidence
Ruthenium-Catalyzed C–H Alkynylation of Aromatic Amides with Hypervalent Iodine–Alkyne Reagents
An
efficient C–H activation method for the <i>ortho</i> alkynylation of aromatic <i>N-</i>methoxyamides with hypervalent
iodine–alkyne reagent using a ruthenium catalyst is described.
The reaction proceeds under mild reaction conditions with broad substrate
scope. A possible catalytic cycle involving a ruthenium carboxylate
assisted C–H bond cleavage is proposed from the preliminary
mechanistic evidence
Rh<sup>III</sup>-Catalyzed [4 + 1] Annulations of 2‑Hydroxy- and 2‑Aminobenzaldehydes with Allenes: A Simple Method toward 3‑Coumaranones and 3-Indolinones
A novel
method for the regio- and stereoselective synthesis of
substituted 3-coumaranones from salicylaldehydes and allenes using
a rhodiumÂ(III) catalyst has been developed. This procedure gives access
to new 2-vinyl-substituted 3-coumaranone compounds. The method involves
a Rh<sup>III</sup>-catalyzed aldehyde C–H activation and annulation
reactions. Moreover, this Rh<sup>III</sup>-catalyzed [4 + 1] annulation
reaction has been applied to 2-aminobenzaldehydes to afford 2,2-disubstituted
3-indolinones
Rh<sup>III</sup>-Catalyzed [4 + 1] Annulations of 2‑Hydroxy- and 2‑Aminobenzaldehydes with Allenes: A Simple Method toward 3‑Coumaranones and 3-Indolinones
A novel
method for the regio- and stereoselective synthesis of
substituted 3-coumaranones from salicylaldehydes and allenes using
a rhodiumÂ(III) catalyst has been developed. This procedure gives access
to new 2-vinyl-substituted 3-coumaranone compounds. The method involves
a Rh<sup>III</sup>-catalyzed aldehyde C–H activation and annulation
reactions. Moreover, this Rh<sup>III</sup>-catalyzed [4 + 1] annulation
reaction has been applied to 2-aminobenzaldehydes to afford 2,2-disubstituted
3-indolinones
Ruthenium-Catalyzed C–H Alkynylation of Aromatic Amides with Hypervalent Iodine–Alkyne Reagents
An
efficient C–H activation method for the <i>ortho</i> alkynylation of aromatic <i>N-</i>methoxyamides with hypervalent
iodine–alkyne reagent using a ruthenium catalyst is described.
The reaction proceeds under mild reaction conditions with broad substrate
scope. A possible catalytic cycle involving a ruthenium carboxylate
assisted C–H bond cleavage is proposed from the preliminary
mechanistic evidence