The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study

AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Minimally invasive procedure for hemorrhoids: Surgical results

Objectives: The purpose of the present study was to determine the surgical results of stapled hemorrhoidectomy and overall satisfaction of the patient and to evaluate its suitability as a routine day care surgery procedure in this part of the world. Materials & Methods: A total of 30 patients were operated from June 2006 to Dec 2008. The median age of the patients was 49.1 years. The main symptom was digital recognition of perianal mass (96%). The procedure was performed under regional (epidural or spinal) or general anesthesia. The average operative time was 31.08 minutes. The procedure was performed with PPH03, a 33 mm diameter hemorrhoidal circular stapler. The patients were prospectively evaluated for postoperative pain and bleeding, satisfaction scores, anorectal function, return to work and cost effectiveness of the procedure. Results: The duration of the PPH procedure ranged from 30-45 minutes (average 31.08 minutes). The suture line was on average 3.5cm (3 - 4.5) above the dentate line. Excision of external skin tags while undergoing PPH was performed in 16.6% cases (n=5). No stapler failure was detected. Seven patients (23.3%) had bleeding after the stapler off and 3 patients (10%) had bleeding in the first post operative day. Patients average pain score was 1.57 (VAS 1-5) at 24 hrs in the 1st postoperative period. Of note, three patients had no pain at all immediately after surgery. No patients had recurrence of hemorrhoidal prolapse, bleeding or anastomotic stricture upon rectal exam or fecal incontinence Ninety percent of patients (n=27) were discharged in a day while as 10% were discharged after 2 days because of their co morbid conditions Return to work was early between 5-7 days postoperatively with high patient satisfaction score. Conclusions: Stapled hemorrhoidectomy (SH) is a safe, effective and well tolerated procedure in the treatment of grade 3 and grade 4 hemorrhoids with less postoperative pain and high patient satisfaction, which seems to have all the requirements for Day Care Surgery

Gastric carcinoma in young patients.

Study Design: Retrospective and prospective hospital based study. Objectives: To study the clinico-pathological features of gastric carcinoma in young patients (<40 years) and compare them with older patients and to know the association of gastric cancer in young patients with P53 gene and compare them with older patients. Method: The present study included 502 patients. Four hundred & fifty-two patients were >40 years of age and 50 patients <40 years of age. Retrospective group included 209 patients and prospective group included 293 patients. Study period was 2004 to 2008. Results: Male to female ratio in young patients was 1:1.08 v/s 2.5:1 in older patients. Family history of stomach cancer was present in 10% and 3% in younger and older patients respectively. Main presenting symptoms was epigastric pain. Mean age of presentation was 35+5.8 in young and 53+4.8 years in older patients. Lower 1/3rd of stomach was main site of lesion in both groups. Young patients had significantly more poorly differentiated histology and older had moderately differentiated histology. Diffuse type of lesions was more common in younger patients. Resectability rate was more in older patients. Most common procedure performed was lower partial gastrectomy with gastrojejunostomy. Invasion of adjacent organs was more common in young patients. Both groups presented with advanced stage disease. Local recurrence was more frequent in young patients. P53 mutations were present in significant percent in older patients as compared to young. P53 mutations were more in smokers as compared to non-smokers. Intestinal type of histology had more expression of P53 than diffuse type. Conclusions: Diffuse or poorly differentiated carcinoma shows poor prognostic results. A gastric lesion in young patients presenting with non-specific symptoms should not be considered benign