A study of cutaneous adverse drug reactions in the outpatient department of Dermatology at a tertiary care center in Gujarat, India

Background: The data for adverse cutaneous drug reactions (ACDRs) is limited in Gujarat. The ACDRs are one of the frequent ADRs and cause of significant morbidity and mortality in patients of all areas of healthcare today. They are responsible for significant number of hospital admissions. Thus, the present study emphasises on the need and importance of an effective pharmacovigilance programme.Methods: A prospective study was undertaken in a 183 cases tertiary care teaching hospital of India. Male to female ratio, most common class of drug, individual drug causing ACDR, common types of ACDRs Parameters were studied. Other Parameters like Causality, preventability and severe or non-severe reactions were analyzed.Results: Majority of the patients (48%) with CADR belonged to the age group 25-44 followed by 45-64 (28%). Most frequent adverse cutaneous drug reactions reported were Urticaria (40%), Maculopapular rash (25%) & Fixed drug eruptions (21%) in decreasing order of frequency. Majority of reactions (96%) were Bizarre/Unpredictable in nature. As a group, antimicrobials (46%) were most frequently associated with CADR followed by NSAIDs (31%) and antiepileptics (11%).  Most of the reactions (93%) were mild-moderate and probable (77%) in nature. Approximately 60% of ACDRs reported in this study were preventable.Conclusions: There was slight male preponderance except acneiform eruptions. Cotrimoxazole being the most common offending drug then after Ibuprofen, Phenytoin among the anti-inflammatory, analgesics, antiepileptics class. Causality assessment resulted in high score 77% of probable category

Investigating Dark Matter-Admixed Neutron Stars with NITR Equation of State in Light of PSR J0952-0607

The heaviest pulsar, PSR J0952-0607, with a mass of $M=2.35\pm0.17 \ M_\odot$, has recently been discovered in the disk of the Milky Way Galaxy. In response to this discovery, a new RMF model, "NITR" has been developed. The NITR model's naturalness has been confirmed by assessing its validity for various finite nuclei and nuclear matter (NM) properties, including incompressibility, symmetry energy, and slope parameter values of 225.11, 31.69, and 43.86 MeV, respectively. These values satisfy the empirical/experimental limits currently available. The maximum mass and canonical radius of a neutron star (NS) calculated using the NITR model parameters are 2.35$M_\odot$ and 12.73 km, respectively, which fall within the range of PSR J0952-0607 and the latest NICER limit. This study aims to test the NITR model consistency by applying it to different systems and, consequently, calibrate its validity extensively. Subsequently, the NITR model equation of state (EOS) is employed to obtain the properties of a dark matter admixed neutron star using two approaches: non-gravitational (single fluid) and two-fluid. In the two-fluid model, the dark matter (DM) particles only interact with each other via gravity rather than the nucleons. In both cases, the equation of state becomes softer due to DM interactions, which reduces various macroscopic properties such as maximum mass, radius, tidal deformability, etc. Additionally, through the use of various observational data, efforts are made to constraint the quantity of DM within the NS