297 research outputs found
Ameliorative Potential of Morin in Streptozotocin-Induced Neuropathic Pain in Rats
- Publication venue
- 'African Journals Online (AJOL)'
- Publication date
- 10/10/2014
- Field of study
Purpose: To investigate the protective effect of morin, a naturally occurring bioflavonoid of Moraceae family, in experimentally-induced diabetic neuropathy (DN) in rats.Methods: Diabetes was induced by a single injection (65 mg/kg, ip) of streptozotocin (STZ). Morin (15 and 30 mg/kg/day) oral treatment was started 3 weeks after diabetes induction and continued for 5 consecutive weeks. Pain threshold behavior tests were performed at the end of the treatment. In sciatic nerve, inflammatory cytokines (TNF-å, IL-1ù, IL-6), nerve growth factor (NGF) and insulin growth factor (IGF-1) were determined using ELISA kits, while thiobarbituric acid reactive substances (TBARS),glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) levels were assessed.Results: Diabetic animals showed apparent decreased paw-withdrawal (39 %, p < 0.05) and tail-flick (31 %, p < 0.05) latency as compared with control group. All the measured biomarkers were altered (p < 0.05 to 0.001) in diabetic rats compared with control non-diabetic animals. Morin treatment attenuated hyperalgesia and analgesia (p < 0.05) respectively. Morin treatment of diabetic rats at both doses significantly decreased the levels of cytokines (p < 0.01), glucose (p < 0.01) and TBARS (p < 0.001), but increased NGF (p < 0.01), IGF-1 (p < 0.01) and GSH (p < 0.01) levels in sciatic nerves compared to untreated diabetic animals. Inhibited activities (U/mg protein) of SOD (1.08 ± 0.16) and CAT (2.77 ± 0.36) in sciatic nerve of diabetic rats also found corrections (2.09 ± 0.11, p < 0.01) and (4.53 ± 0.57, p < 0.01) after morin (30 mg/kg/day) treatment, compared with untreated diabetic animals.Conclusion: These findings demonstrate the protective effect of morin mediated through reduction of oxidative stress and inflammatory process, and suggest the therapeutic potential of morin in the attenuation of diabetic neuropathy.Keywords: Morin, Diabetes, Neuropathy pain, Oxidative stress, Anti-inflammator
Statistical analysis plan for the motor neuron disease systematic multi-arm adaptive randomised trial (MND-SMART)
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 16/01/2023
- Field of study
Background: MND-SMART is a platform, multi-arm, multi-stage, multi-centre, randomised controlled trial recruiting people with motor neuron disease. Initially, the treatments memantine and trazodone will each be compared against placebo, but other investigational treatments will be introduced into the trial later. The co-primary outcomes are the Amyotrophic Lateral Sclerosis Functional Rating Scale Revised (ALS-FRS-R) functional outcome, which is assessed longitudinally, and overall survival. Methods: Initially in MND-SMART, participants are randomised 1:1:1 via a minimisation algorithm to receive placebo or one of the two investigational treatments with up to 531 to be randomised in total. The comparisons between each research arm and placebo will be conducted in four stages, with the opportunity to cease further randomisations to poorly performing research arms at the end of stages 1 or 2. The final ALS-FRS-R analysis will be at the end of stage 3 and final survival analysis at the end of stage 4. The estimands for the co-primary outcomes are described in detail. The primary analysis of ALS-FRS-R at the end of stages 1 to 3 will involve fitting a normal linear mixed model to the data to calculate a mean difference in rate of ALS-FRS-R change between each research treatment and placebo. The pairwise type 1 error rate will be controlled, because each treatment comparison will generate its own distinct and separate interpretation. This publication is based on a formal statistical analysis plan document that was finalised and signed on 18 May 2022. Discussion: In developing the statistical analysis plan, we had to carefully consider several issues such as multiple testing, estimand specification, interim analyses, and statistical analysis of the repeated measurements of ALS-FRS-R. This analysis plan attempts to balance multiple factors, including minimisation of bias, maximising power and precision, and deriving clinically interpretable summaries of treatment effects. Trial registration: EudraCT Number, 2019â000099-41. Registered 2 October 2019, https://www.clinicaltrialsregister.eu/ctr-search/search?query=mnd-smart ClinicalTrials.gov, NCT04302870. Registered 10 March 2020
Heparan Sulfate Regrowth Profiles Under Laminar Shear Flow Following Enzymatic Degradation
- Author
- A Koo
- A Remuzzi
- AB Baker
- AG Khan
- Andrew Jia-An Koo
- AW Gross
- AW Mulivor
- AW Mulivor
- BM Berg van den
- C. Forbes Dewey
- CK Payne
- D Chappell
- DR Potter
- EC Kennett
- EE Ebong
- G Dai
- G Rao
- G. Villarreal
- Guillermo Garcia-Cardena
- HH Lipowsky
- I Shafat
- I Vlodavsky
- I Vlodavsky
- IV Fuki
- JA Florian
- Jagadish Sankaran
- JD Esko
- Jennifer H. Shin
- Jiro Sakai
- KM Ainslie
- KM Parmar
- Kristina M. Giantsos-Adams
- L Gao
- M Nikmanesh
- M Yanagishita
- M. Gouverneur
- ML Ballinger
- MY Pahakis
- NM Carter
- P Zimmermann
- R. O. Dull
- RH Adamson
- S Sarrazin
- S. Reitsma
- Sukhyun Song
- T Arisaka
- TR Rudd
- V Ferro
- X Bai
- Y Takeuchi
- Y Yao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/11/2012
- Field of study
The local hemodynamic shear stress waveforms present in an artery dictate the endothelial cell phenotype. The observed decrease of the apical glycocalyx layer on the endothelium in atheroprone regions of the circulation suggests that the glycocalyx may have a central role in determining atherosclerotic plaque formation. However, the kinetics for the cellsâ ability to adapt its glycocalyx to the environment have not been quantitatively resolved. Here we report that the heparan sulfate component of the glycocalyx of HUVECs increases by 1.4-fold following the onset of high shear stress, compared to static cultured cells, with a time constant of 19 h. Cell morphology experiments show that 12 h are required for the cells to elongate, but only after 36 h have the cells reached maximal alignment to the flow vector. Our findings demonstrate that following enzymatic degradation, heparan sulfate is restored to the cell surface within 12 h under flow whereas the time required is 20 h under static conditions. We also propose a model describing the contribution of endocytosis and exocytosis to apical heparan sulfate expression. The change in HS regrowth kinetics from static to high-shear EC phenotype implies a differential in the rate of endocytic and exocytic membrane turnover.National Heart, Lung, and Blood Institute (Grant HL090856-01)Singapore-MIT Allianc
Gout and risk of chronic kidney disease and nephrolithiasis: meta-analysis of observational studies
- Author
- AK Bello
- B Bose
- C Hsu
- C Kuo
- C Padang
- C Scales
- CA Sarawate
- CF Kuo
- CF Kuo
- Christian D Mallen
- D Khanna
- DH Solomon
- E Krishnan
- E Pascual
- E Roddy
- E Roddy
- E Roddy
- E Roddy
- Edward Roddy
- EN Taylor
- EN Taylor
- ES Johnson
- F Liote
- FP Cappuccio
- G Trifiro
- H El-Zawawy
- HJ Kramer
- HK Choi
- HM Kramer
- JB OâSullivan
- JB Rosenfeld
- JH Kellgren
- John Belcher
- JPT Higgins
- K Matsushita
- KH Yu
- L Berger
- L Cea Soriano
- LG Glynn
- LR Harrold
- M Jin
- Matthew J Roughley
- MJ Fuldeore
- MS Parmar
- MY Lin
- N Chen
- National Institute for Health and Care Excellence
- National Kidney Foundation
- OB Schaffalitzky De Muckadell
- P Soltész
- PE Stevens
- PH Bennett
- R Ando
- RT Keenan
- S Lusignan de
- SE Liebman
- SL Wallace
- TF YĂŒ
- TF YĂŒ
- TR Mikuls
- VC Kok
- WJ Currie
- WJ Currie
- WJ Fessel
- Y Zhu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Efficacy of Major Plant Extracts/Molecules on Field Insect Pests
- Author
- A Bermejo
- A Bozsik
- A Cavé
- A Guadaño
- A Krishnamurthi
- A Kumar
- A Mondal
- A Prakash
- A Valencia
- AD Solsoloy
- AD Solsoloy
- AI Rocha Da
- AJ Mordue
- AJ Mordue
- AK Tripathi
- AP Jarvis
- AP Jarvis
- AP Jarvis
- AV Reddy
- AW Richard
- B Meera
- B Murray
- B Ratnakumari
- B Rojano
- B Talopatra
- B Venkateswarlu
- BS Chandel
- BS Parmar
- C Thebtaranonth
- CM Boursier
- CM Priestley
- CW Sabandar
- D Chauhan
- D Ocampo
- D Prijono
- D Roy
- D Singh
- D Singh
- DA AdabieâGomez
- DAH Taylor
- DM Secoy
- DR Schroeder
- DS Alves
- EE Enan
- EJ Carcache-Blanco
- EL Scudeler
- EO Okonkwo
- ES Atawodi
- F Hasan
- FO Alao
- FQ Alali
- FQ Alali
- FR Chang
- G Ahmad
- G Goel
- G Parra-Henao
- G Schmahl
- G Shi
- GA Cordell
- GE Shi
- GE Veitch
- GF Antonious
- GK Bunker
- GM Liang
- GN Silva
- GP Garg
- H Rembold
- H Rembold
- H Rembold
- H Schmutterer
- H Schmutterer
- H Schmutterer
- H Schmutterer
- H Yin
- HA Johnson
- HAF Shafie El
- HB Broughton
- HI Katoune
- HM Kotkar
- HPS Makkar
- HPS Makkar
- HPS Makkar
- I Gelbic
- J Fontana
- J Kumar
- J Leatemia
- J Paul
- J Pereira
- JB Stokes
- JD Warthen
- JH Butterworth
- JH Butterworth
- JK Rupprecht
- JR Tormo
- K Biswas
- K Ermel
- K He
- K Simin
- K SlĂĄma
- KB Jadhau
- KC Chitra
- KD Rakshit
- KI Ahammadsahib
- KK Mohanty
- KMS Sundaram
- KMS Sundaram
- KMS Sundaram
- KMS Sundaram
- KO Adebowale
- L Jing
- L Lal
- L Li
- L Mengual
- L Zeng
- LE Castillo
- LP Ribeiro
- LW Chatrou
- M Bobadilla
- M Feldhege
- M Khalequzzaman
- M Khalequzzaman
- M Kumar
- M Leboeuf
- M Mazid
- M Rajguru
- M Sauerwein
- M Shrinivas
- MA Barnby
- MB Isman
- MB Isman
- MB Isman
- MB Isman
- MF Maia
- ML Pappas
- MN Acda
- MO Nwosu
- MY RĂos
- N Ahmad
- N Dhandapani
- N Khumrungsee
- National Research Council (NRC)
- NV Brinji
- NVS Rao
- O Koul
- O Koul
- O Koul
- O Onunkun
- O Ălvarez
- O Ălvarez
- OA CĂłlom
- OA CĂłlom
- OP Sidhu
- OP Sidhu
- P Cabone
- P Robledo-Reyes
- PP Yadav
- PR Sharma
- Premchand
- PV Pawar
- PWC Green
- R Pavela
- R Pavela
- R Pavela
- R PĂ©rez-Pacheco
- R Singh
- RB Yamasaki
- RB Yamasaki
- RC Seffrin
- RE Unicini Manganelli
- RJ Aerts
- RK Devappa
- RK Devappa
- RK Devappa
- RK Lindquist
- RS Susarla
- S Alam
- S Gopalakrishnan
- S Irulandi
- S Johnson
- S Mahey
- S Parvin
- S Pineda
- S Shameel
- S Shukla
- S Yule
- SB Malik
- SD Jolad
- SD Katekhaye
- SK Pavanaram
- SM Packiam
- SR Reena
- SS Martinez
- SS Nathan
- SS Nathan
- SS Nathan
- SS Shelke
- SS Shelke
- SV Ley
- T Colman-Saizarbitoria
- TR Govindachari
- V Bullangpoti
- V Kumar
- V Ravindra
- V Rozman
- V Sathyaseelan
- V Sharma
- V Sharma
- W Adolf
- W Haas
- W Kraus
- WB Akanbi
- WM Blaney
- XP Fang
- YP Singh
- ZA Habou
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
Insect pests are considered the major hurdle in enhancing the production and productivity of any farming system. The use of conventional synthetic pesticides has led to the emergence of pesticide-resistant insects, environmental pollution, and negative effects on natural enemies, which have caused an ecological imbalance of the predator-prey ratio and human health hazards; therefore, eco-friendly alternative strategies are required. The plant kingdom, a rich repertoire of secondary metabolites, can be tapped as an alternative for insect pest management strategies. A number of plants have been documented to have insecticidal properties against various orders of insects in vitro by acting as antifeedants, repellents, sterilant and oviposition deterrents, etc. However, only a few plant compounds are applicable at the field level or presently commercialised. Here, we have provided an overview of the broad-spectrum insecticidal activity of plant compounds from neem, Annona, Pongamia, and Jatropha. Additionally, the impact of medicinal plants, herbs, spices, and essential oils has been reviewed briefl
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Search for new Higgs bosons via same-sign top quark pair production in association with a jet in proton-proton collisions at âs = 13 TeV
- Author
- Aarrestad TK
- Aarup Petersen H
- Abbaneo D
- Abbiendi G
- Abbott S
- Abbrescia M
- Abdalla H
- Abdullin S
- Abreu A
- Abu Zeid S
- Acharya H
- Acharya S
- Acosta D
- Adam W
- Adamidis K
- Adams MR
- Adams T
- Addesa FM
- Adloff C
- Adzic P
- Aebi D
- Afanasiev S
- Agapitos A
- Agarwal G
- Agram J-L
- Aguilar-Benitez M
- Agyel D
- Ahmad A
- Ahmad M
- Ahmed A
- AimĂš C
- Ajmal S
- Akchurin N
- Akgun B
- Akpinar A
- Al Kadhim A
- Albert A
- Albrecht A
- Albrecht S
- Albrow M
- Alcaraz Maestre J
- Alcerro Alcerro LF
- Aldaya Martin M
- AldĂĄ JĂșnior WL
- Aleksandrov A
- Alexander J
- Alhusseini M
- Alimena J
- Alison J
- Allmond B
- Ally D
- Almond J
- Alpana A
- Alsufyani B
- Alvarez Gonzalez B
- Alverson G
- Alves Gallo Pereira M
- Alves GA
- Aly R
- Alyari M
- Amapane N
- Ambrozas M
- Ameen MM
- Amendola C
- Amoroso S
- Amram O
- Amsler C
- An S
- An Y
- Anagnostou G
- Andrea J
- Andreev V
- Andreev Y
- Andrejkovic JW
- Andrews MB
- Androsov K
- Anguiano J
- Antchev G
- Anthony D
- Antonello M
- Apollinari G
- Apparu D
- Appelt E
- Apresyan A
- Araujo M
- Aravind A
- Arcaro D
- Arcidiacono R
- Ardino R
- Argiro S
- Arneodo M
- Aruta C
- Asawatangtrakuldee C
- Asenov P
- Asghar MI
- Asilar E
- Askew A
- Assiouras P
- Assran Y
- Atakisi IO
- Attikis A
- Auffray E
- Aushev T
- Auzinger G
- Avati V
- Avery P
- Avila C
- Awais A
- Awan MIM
- Ayala E
- Ayala G
- Aydilek O
- Azarkin M
- Azzi P
- Azzurri P
- Baarmand MM
- Babaev A
- Babbar J
- Bacchetta N
- Bachtis M
- Backhaus M
- Baden A
- Baechler J
- Bagliesi G
- Bahinipati S
- Bainbridge R
- Bak G
- Bakas G
- Bakhshiansohi H
- Bakshi AS
- Bala A
- Baldenegro Barrera C
- Ball AH
- Bam B
- Ban Y
- Band R
- Bandyopadhyay H
- Banerjee S
- Banerjee S
- Bansal S
- Baradia S
- Barbagli G
- Barberis E
- Barbosa Trujillo DA
- Bardelli G
- Bargassa P
- Baringer P
- Barman S
- Barnes VE
- Barney D
- Barria P
- Barroso Ferreira Filho M
- Bartek R
- Bartosik N
- BartĂłk M
- Barzdukas A
- Basnet A
- Bastos D
- Battilana C
- Baty A
- Bauer G
- Bauerdick LAT
- Bautista I
- Baxter S
- Bayatmakou M
- Bean A
- Beauceron S
- Beaudette F
- Becerril Gonzalez H
- Bedoya CF
- Behera PK
- Behera SC
- Behnke O
- Bein S
- BeirĂŁo Da Cruz E Silva C
- Belforte S
- Bell KW
- Bellan R
- Belloni A
- Bellora A
- Belvedere A
- Belyaev A
- Belyaev A
- Benaglia A
- Benato L
- Bencze G
- Bendavid J
- Benecke A
- Benelli G
- Benitez JF
- Bennett C
- Benussi L
- Bergauer T
- Beri SB
- BermĂșdez MartĂnez A
- Bernardes CA
- Berry D
- Berryhill J
- Besancon M
- Bestintzanos I
- Bethani A
- Bevilacqua T
- Beyrouthy T
- Bhardwaj A
- Bharthuar S
- Bhat PC
- Bhatnagar V
- Bhattacharya R
- Bhattacharya S
- Bhattacharya S
- Bhattacharya S
- Bhowmik D
- Bhowmik S
- Bhyun JH
- Bialkowska H
- Bianchini L
- Bianco M
- Bianco S
- Biino C
- Bilei GM
- Bilin B
- Bin Anuar AA
- Bin Norjoharuddeen N
- Bisello D
- Black K
- Blanco FernĂĄndez S
- Blancon B
- Blekman F
- Blend D
- Blinov V
- Bloch D
- Bloch P
- Bloom K
- Bluj M
- Blumenfeld B
- Boccali T
- Bocci A
- Bodek A
- Boimska B
- Boldrini G
- Boletti A
- Bols ES
- Bonacorsi D
- Bonanomi M
- Bonilla J
- Boos E
- Boran F
- Borgonovi L
- Bornheim A
- Borras K
- Borshch V
- Bortignon P
- Bose T
- Bossini E
- Botta C
- Botta V
- Bouchamaoui H
- Boudoul G
- Bouhali O
- Bourilkov D
- Bower N
- Boyaryntsev A
- Bozzo M
- Bragagnolo A
- Braghieri A
- Brainerd C
- Brandao Malbouisson H
- Branson JG
- Breedon R
- Brennan L
- Brew C
- Bright-Thonney S
- Brigljevic V
- Brinkerhoff A
- Brivio F
- Brochero Cifuentes JA
- Brom J-M
- Brommer S
- Brondolin E
- Brooke JJ
- Brown CE
- Brown RM
- Brunner D
- Bruno G
- Bruschini D
- Bryant P
- Bryson M
- Brzhechko D
- BrĂŒcken E
- Bubanja I
- Bucci R
- Buchmuller O
- Buchot Perraguin A
- Budkouski D
- Bueghly J
- Bundock A
- Bunichev V
- Bunkowski K
- Buontempo S
- Burkart M
- Burkett K
- Bury F
- Busson P
- Busza W
- Butalla S
- Butler JN
- Butler PH
- Butz E
- Bylsma B
- BĂ€rtschi P
- Cabrera A
- Cabrillo IJ
- Cacchio V
- Cadamuro L
- Cagnotta A
- Caillol C
- Cakir A
- Calandri A
- Calderon De La Barca Sanchez M
- Calderon A
- Cali IA
- Calligaris L
- Calzaferri S
- Camaiani B
- Caminada L
- Campagnari C
- Campana M
- Campanini R
- Campbell A
- Camporesi T
- Candelise V
- Canelli MF
- Canepa A
- Cankocak K
- Capiluppi P
- Cappati A
- Caputo C
- Caraway B
- Cardini A
- Cardwell B
- Carlin R
- Carnahan T
- Carnevali F
- Carrera Jarrin E
- Carrigan M
- Carrillo Montoya CA
- Cartiglia N
- Carvalho W
- Casarsa M
- Cassese A
- Castaldi R
- Castaneda Hernandez A
- Castells S
- Castilla-Valdez H
- Castro A
- Cavallari F
- Cavallo FR
- Cavallo N
- Cavanaugh R
- Cazzaniga C
- Ceard L
- Ceccarelli R
- Cepeda M
- Cerati GB
- Cerci S
- Cerminara G
- Cerrada M
- Cerri O
- Cetorelli F
- Chabert EC
- Chahal GS
- Chandra S
- Chang P
- Chanon N
- Chao Y
- Charlot C
- Chatagnon P
- Chatterjee RM
- Chatterjee S
- Chatterjee S
- Chatzistavrou T
- Chaudhary G
- Chauhan S
- Chawla R
- Checchia P
- Chekhovsky V
- Chen GM
- Chen HS
- Chen KF
- Chen M
- Chen PS
- Chen X
- Chen Y
- Chen YM
- Chen Z
- Chen ZG
- Chenarani S
- Cheng C
- Cheng T
- Cherepanov V
- Chernyavskaya N
- Chertok M
- Cheung HWK
- Chhetri A
- Chiarito B
- Chinellato J
- Chistov R
- Chitroda BK
- Chlebana F
- Choi J
- Choi J
- Choi M
- Choi S
- Chou JP
- Choudhary BC
- Christoforou K
- Chudasama R
- Chwalek T
- Ciangottini D
- Ciocci MA
- Cipriani M
- Citron M
- Cittolin S
- Ciulli V
- Civinini C
- Claes DR
- Clare R
- Clement E
- Clerbaux B
- Cockerill DJA
- Coelho E
- Colaleo A
- Coldham K
- Coldham K
- Cole JE
- Colino N
- Collard C
- Colling D
- Colombina F
- Connor P
- Consuegra RodrĂguez S
- Contardo D
- Conway J
- Cooke C
- Cooper SI
- Cooperstein S
- Corcodilos L
- Cormier K
- Correia Silva G
- Cosby C
- Cossutti F
- Costa M
- Costa S
- Coubez X
- Couderc F
- Cousins R
- Covarelli R
- Cox B
- Cox PT
- Cranshaw DJ
- Creanza D
- Cremaldi LM
- Cremonesi M
- Crossman B
- CsanĂĄd M
- Csorgo T
- Cuevas J
- Cuffiani M
- Cumalat JP
- Cummings G
- Cunqueiro Mendez L
- Cussans D
- Cutts D
- Czellar S
- D'Alessandro R
- D'Alfonso M
- D'Amante V
- D'Anzi B
- d'Enterria D
- D'Hondt J
- Da Costa EM
- Da Molin G
- Da Silveira GG
- Dabrowski A
- Dalchenko M
- Dallavalle GM
- Damanakis K
- Damas F
- Damgov J
- Dancu JS
- Danilov M
- Dansana S
- Darwish MR
- Das A
- Das AK
- Das I
- Das P
- Das S
- Daskalakis G
- Dasu S
- Datta A
- Datta K
- Dauncey P
- David A
- Davies G
- Davies J
- Davignon O
- Davis J
- de Barbaro P
- De Bruyn I
- De Coen M
- De Cosa A
- De Filippis N
- De Guio F
- De Iorio A
- De Jesus Damiao D
- De La Cruz B
- De La Cruz-Burelo E
- De Lentdecker G
- De Leo K
- De Moor A
- De Palma M
- De Roeck A
- De Silva M
- de TrocĂłniz JF
- De Wit A
- Defranchis MM
- Deile M
- Dejardin M
- Del Burgo R
- Del Re D
- Delaere C
- Delannoy AG
- Delcourt M
- Delgado Peris A
- Dell'Orso R
- Della Negra M
- Della Ricca G
- Demaria N
- Demina R
- Demiragli Z
- Demiroglu ZS
- Denegri D
- Depasse P
- Dermenev A
- Dervan J
- Dewanjee RK
- Dezoort G
- Dharmaratna WGD
- Dhingra N
- Di Florio A
- Di Marco E
- Di Mattia A
- Diaz D
- Dickinson J
- Diekmann S
- Diemoz M
- Dierlamm A
- Dilsiz K
- Dimitrov A
- Dimova T
- Dinardo ME
- Dini P
- Diotalevi T
- Dissertori G
- Dittmann J
- Dittmar M
- Dittmer S
- Dobson M
- Dobur D
- Dodonova A
- Dogra S
- Dolek F
- Dolen J
- Dominguez A
- Donato S
- DonegĂ M
- Donertas IS
- Dordevic M
- Dorigo T
- Doroba K
- Dorsett A
- Dozen C
- Dragicevic M
- Dreimanis K
- Droll A
- Druzhkin D
- Duarte Campderros J
- Duarte J
- Dube S
- Dubinin M
- Dudko L
- Dugad S
- Dulemba JL
- Dumanoglu I
- Durkin LS
- Dutta I
- Dutta S
- Dutta S
- Dutta V
- Dziwok C
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- Yusuff I
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- Zuolo D
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- Publication venue
- Elsevier
- Publication date
- 02/02/2024
- Field of study
Data availability:
Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS policy as stated in âCMS data preservation, re-use and open access policyâ available online at: https://cms-docdb.cern.ch/cgi-bin/PublicDocDB/RetrieveFile?docid=6032&filename=CMSDataPolicyV1.2.pdf&version=2 .A preprint of this article is available online at arXiv:2311.03261v2 [hep-ex] https://arxiv.org/abs/2311.03261v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/TOP-22-010 (CMS Public Pages)A search is presented for new Higgs bosons in proton-proton (pp) collision events in which a same-sign top quark pair is produced in association with a jet, via the pp â tH/A â ttÂŻc and pp â tH/A â ttÂŻu processes. Here, H and A represent the extra scalar and pseudoscalar boson, respectively, of the second Higgs doublet in the generalized two-Higgs-doublet model (g2HDM). The search is based on pp collision data collected at a center-of-mass energy of 13 TeV with the CMS detector at the LHC, corresponding to an integrated luminosity of 138 fbâ1. Final states with a same-sign lepton pair in association with jets and missing transverse momentum are considered. New Higgs bosons in the 200-1000 GeV mass range and new Yukawa couplings between 0.1 and 1.0 are targeted in the search, for scenarios in which either H or A appear alone, or in which they coexist and interfere. No significant excess above the standard model prediction is observed. Exclusion limits are derived in the context of the g2HDM.SCOAP3
Recommended from our members
Search for long-lived heavy neutral leptons with lepton flavour conserving or violating decays to a jet and a charged lepton
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- Aarup Petersen H
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- Publication venue
- Springer Nature on behalf of SISSA
- Publication date
- 19/03/2024
- Field of study
A preprint version of the article is available at arXiv:2312.07484v3 [hep-ex], https://arxiv.org/abs/2312.07484 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/EXO-21-013 (CMS Public Pages)A search for long-lived heavy neutral leptons (HNLs) is presented, which considers the hadronic final state and coupling scenarios involving all three lepton generations in the 2-20 GeV HNL mass range for the first time. Events comprising two leptons (electrons or muons) and jets are analyzed in a data sample of proton-proton collisions, recorded with the CMS experiment at the CERN LHC at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 138 fbâ1. A novel jet tagger, based on a deep neural network, has been developed to identify jets from an HNL decay using various features of the jet and its constituent particles. The network output can be used as a powerful discriminating tool to probe a broad range of HNL lifetimes and masses. Contributions from background processes are determined from data. No excess of events in data over the expected background is observed. Upper limits on the HNL production cross section are derived as functions of the HNL mass and the three coupling strengths VâN to each lepton generation â and presented as exclusion limits in the coupling-mass plane, as lower limits on the HNL lifetime, and on the HNL mass. In this search, the most stringent limit on the coupling strength is obtained for pure muon coupling scenarios; values of |VÎŒN|2 > 5 (4) Ă 10â7 are excluded for Dirac (Majorana) HNLs with a mass of 10 GeV at a confidence level of 95% that correspond to proper decay lengths of 17 (10) mm.SCOAP3
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- Aarup Petersen H
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- WĂŒrthwein F
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- Xiao M
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- Yang Y
- Yang YC
- Yao Y
- Yarar H
- Yates BR
- Yazgan E
- Ye Y
- Ye Z
- Yi K
- Yi R
- Yigitbasi E
- Yockey H
- Yohay R
- Yoo HD
- Yoo J
- Yoo J
- Yoon I
- You Z
- Yu D
- Yu I
- Yu SS
- Yuan L
- Yuan S
- Yuldashev BS
- Yusuff I
- Zabi A
- Zabolotny W
- Zacharopoulou A
- Zaleski S
- Zalewski P
- Zanetti M
- Zarubin A
- Zarucki M
- Zaza A
- Zecchinelli AG
- Zehetner P
- Zeinali M
- Zejdl P
- Zeuner WD
- Zghiche A
- Zhang F
- Zhang H
- Zhang J
- Zhang L
- Zhang W
- Zhang Y
- Zhizhin I
- Zhokin A
- Zhou C
- Zhu RY
- Ziemons T
- Zilizi G
- Zimermmane Castro Santos A
- Zipper N
- Zisopoulos I
- Zoi I
- Zolkapli Z
- Zorbakir IS
- Zorbilmez C
- Zotto P
- Zotz A
- Zou R
- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Zygala L
- Publication venue
- American Physical Society (APS)
- Publication date
- 14/08/2024
- Field of study
A preprint version of this article is available at arXiv:2402.13864v2 [hep-ex], https://arxiv.org/abs/2402.13864 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/SMP-22-015 (CMS Public Pages). Report number: CMS-SMP-22-015, CERN-EP-2024-010 .Energy correlators that describe energy-weighted distances between two or three particles in a hadronic jet are measured using an event sample of â = 13ââTeV proton-proton collisions collected by the CMS experiment and corresponding to an integrated luminosity of 36.3ââfb^â1. The measured distributions are consistent with the trends in the simulation that reveal two key features of the strong interaction: confinement and asymptotic freedom. By comparing the ratio of the measured three- and two-particle energy correlator distributions with theoretical calculations that resum collinear emissions at approximate next-to-next-to-leading-logarithmic accuracy matched to a next-to-leading-order calculation, the strong coupling is determined at the boson mass: âĄ() = 0.122âą9+0.0040 â0.0050, the most precise âĄ() value obtained using jet substructure observables.SCOAP3
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- Zuolo D
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- Ălvarez CR
- Publication venue
- Springer Nature
- Publication date
- 04/09/2024
- Field of study
A preprint version of the article is available at: arXiv:2402.15366v2 [physics.ins-det], https://arxiv.org/abs/2402.15366 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://cms-results.web.cern.ch/cms-results/public-results/publications/MLG-23-001 (CMS Public Pages). Report numbers: CMS-MLG-23-001, CERN-EP-2023-303.Data Availability: No datasets were generated or analyzed during the current study.Computing demands for large scientific experiments, such as the CMS experiment at the CERN LHC, will increase dramatically in the next decades. To complement the future performance increases of software running on central processing units (CPUs), explorations of coprocessor usage in data processing hold great potential and interest. Coprocessors are a class of computer processors that supplement CPUs, often improving the execution of certain functions due to architectural design choices. We explore the approach of Services for Optimized Network Inference on Coprocessors (SONIC) and study the deployment of this as-a-service approach in large-scale data processing. In the studies, we take a data processing workflow of the CMS experiment and run the main workflow on CPUs, while offloading several machine learning (ML) inference tasks onto either remote or local coprocessors, specifically graphics processing units (GPUs). With experiments performed at Google Cloud, the Purdue Tier-2 computing center, and combinations of the two, we demonstrate the acceleration of these ML algorithms individually on coprocessors and the corresponding throughput improvement for the entire workflow. This approach can be easily generalized to different types of coprocessors and deployed on local CPUs without decreasing the throughput performance. We emphasize that the SONIC approach enables high coprocessor usage and enables the portability to run workflows on different types of coprocessors.SCOAP3. Open access funding provided by CERN (European Organization for Nuclear Research
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
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- ?ivko Iris
- Abbass Hakam
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- Ferguson Susan
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- Godement Mathieu
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- Goebeler M.E.
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- Goralski Patricia
- Gordon Anthony C.
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- Hall Alistair S
- Hall Amelia
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- Harrison Susan
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- Hernandez Erik
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- Hierons Sarah
- Higgins Alisa M.
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- Hill Dianne
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- Hodge Christopher
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- Honda Hitoshi
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- Horner Dan
- Hornsby James
- Horton Michelle
- Horvat Christopher M.
- Howcroft Clare
- Howell Alice
- Hower Martin
- Howie Lucy
- Howle Ryan
- Hoxha Elvira
- Huang David T.
- Hughes Debbie
- Hugill Keith
- Huijbens Danique
- Hullegie Sebastiaan
- Hulley Amanda
- Hulme Jonathan
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- Hunt Beverley
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- Hussain Mahwish
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- HĂŒning Vanessa
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- Irving Ben
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- Jan Hassing Robert
- Janin Pierre
- Jarczak Dominik
- Jarman Claire
- Jayakumar Deva
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- Jean-Pierre Eraldi
- Jeblaoui Asma
- Jenkins Samuel
- Jenkins Sarah
- Jenkins Steve
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- Jerenec Katja
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- Jin Xia
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- Jongebloed Katherine
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- Karlikowski Michal
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- Keeler Sheryl
- Keen Alexandra
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- Khoud Ahmed
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- Kidwai Aneela
- Kiiski Heikki
- Kilner Mari
- Kim Edy Y.
- Kimpton Sarah
- King Andrew
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- Kirk Jill
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- Kirkham Simon
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- Klein Daniela
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- Kochanek Matthias
- Kochert Erik
- Koelink Maaike
- Koirala Kanchan
- Koirala Sabin
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- Kolovou Angeliki
- Konecny Pam
- Kong Jing
- Koopmans Matty
- Kosa Alma
- Kremling Julius
- KreĂ Gabriele
- Krishnamoorthy S
- Krishnamurthy Vinodh
- Kruger Peter
- Kruisdijk-Gerritsen Arriette
- Kruisselbrink Rebecca
- Kuitunen Anne
- Kumar Anand
- Kumar Nikhil
- Kumar Rohit
- Kummerlen Christine
- Kunishima Hiroyuki
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- Kunz Kevin
- Kurenda Catherine
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- Kuybida Yuriy
- Kwan Yvonne
- Kyeremeh Lynsey
- Kyle Laura
- L?Hotellier Sylvie
- Labbe Vincent
- Laffan Mike
- Laffey John
- Laha Shondipon
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- Lambert Bridget
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- Lampro Lamprini
- Landais Michaël
- Landoni Giovanni
- Landsiedel-Mechenbier Elke
- Lang Eva
- Langridge Emma
- Latham Victoria
- Latino Reece
- Laudi Svenja
- Laugs Fabian
- Lavana Jayshree
- Laver Russell D.
- Law Daniel
- Lawler Patrick R.
- Le Basnier Elliot
- Le Guen LenaĂŻg
- Le Loup Guillaume
- Leaf David E.
- Lean Richard
- Leaver Susannah
- Leavis Helen
- Leblond Julie
- Leditschke Anne
- Lee Kelvin
- Lee Stephanie
- Lee Stephen
- Lefevre Montaine
- Leffelaar Evelien
- Lehalleur Adrien
- Lellouche Francois
- Lemaire-Brunel Delphine
- Lembo Rosalba
- Leparco CĂ©cile
- Leroyer Marie-Helene
- Lesona Eden
- Levett Chris
- Lewis Joanne
- Lewis Roger J.
- Lewis Sarah
- LewisProsser Lorraine
- Liao Angela
- Lim Rosario
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- Lindergard Gabriella
- Linnett Vanessa
- Linstrum Kelsey M.
- Litton Ed
- Litton Edward
- Liu Theresa
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- Lockett Teresa
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- LĂłpez Rafael
- Löbel Madlen
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- Maharjan Mili
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- Malfroy Sylvain
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- Maquigneau Natacha
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- Mariappa Vasanth
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- Marin?ek Martin
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- Marmol Joy
- Marnai Remy
- Marriot Cheryl
- Marriott Yvonne
- Marroquin Oscar
- Marsden Tracy
- Marsh Emma
- Marshall John C.
- Marshall Lucy
- Marten Nicole
- Martin Elise
- Martin Emma
- Martin Jane
- Martin Laila
- Martin Timothy
- Martin-Lazarro Juan
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- Martynoga Robert
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- Mason Brittany
- Masood Sobia
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- Masse Marie-Helene
- Massey Natalie
- Masters Kristy
- Mataliotakis Michail
- Mathew Meghena
- Mathew Moncy
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- Matthews Julie
- Maxime Virginie
- Mayak Katelyn
- Mayangao Irving
- Maynard Victoria
- Mayr Florian
- Mc-Kenzie Josette
- McAdams David
- McArthur Colin J.
- McAuley Daniel F.
- McAuley Julie
- McCallion Edmund
- McCarthy Aine
- McClintock Declan
- McConnochie Rachael
- McCracken Phoebe
- McCreary Erin
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- McCullagh Liz
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- McCullough James
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- McDyer John
- McEldrew Ben
- McEldrew Rebecca
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- McGain Forbes
- McGarry Karen
- McGhee Christopher
- McGlothlin Anna
- McGloughlin Steve
- McGlynn Deborah
- McGoldrick Clare
- McGuigan Peter
- McGuinness Shay P.
- McIntyre Joanne
- McIntyre Lauralyn
- McKee Madeleine
- McKenna Shirley
- McKenna Sonia
- Mckeon Laurie
- Mclaughlan Danielle
- McMaster Moyra
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- McMorrow Liam
- McNamara Amanda
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- McNicholas Bairbre
- McQuilten Zoe
- McVerry Bryan J.
- McWilliam Stephen
- Medhurst Laura
- Medva Rebecca
- Meermeier Werner
- Megarbane Bruno
- Mehrtens Jan
- Mehta Reena
- Meijer Karina
- Menon David
- Mercier Emmanuelle
- Mercier Romain
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- Mevavala Bhaumik
- Mew Louise
- Meyer Jason
- Mezher Chaouki
- Meziani Ferhat
- Mfuko Celina
- Mguni Nhlanhla
- Michael Angiy
- Michalak-Glinska Natalia
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- Morgan Matt
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- Morris Lucy
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- Mouncey Paul R.
- Mowery Brent
- Mrad Aymen
- Mtuwa Shelia
- Mukherjee Dipak
- Mulder John
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- Mwaura Esther
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- Naeem Anas
- Naidu Brintha
- Naim Giulia
- Nair Priya
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- Newman Tabitha
- Ng Anthony
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- Nguyen-Valat Thi-My-Hue
- Nichol Alistair D.
- Nicholier Tiphaine
- Nicholson Andrew
- Nicholson Anne
- Nicholson Sarah
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- O Rourke Kate
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- O'Kell Eleanor
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- Ochin Evelina
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- Osborne Jason
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- Owen David R. J.
- Oza Deepali
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- Panwar Rakshit
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- Paramasivam Elankumaran
- Parekh Dhruv
- Parikh Harshel G.
- Parke Rachael L.
- Parker Jane C.
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- Polgarova Petra
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- Raj Ashok
- Ralston Maximillian
- Ramakrishnan N
- Ramali Mohamed
- Ramamurthi Balaji
- Ramanan Mahesh
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- Ranganathan Lakshmi
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- Rowan Kathryn M.
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- Roy Alistair
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- Sandhu Gyan
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- Sathianathan Kushaharan
- Sathianathan Prasannakumari
- Saull Michelle
- Saunders Christina T.
- Saunderson Paula
- Sauras-ColĂłn Esther
- Saxena Manoj
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- Siika Wangari
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- Singleton Jo
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- Williamson James D
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- Wilson Maggie
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- Winters Lauren
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- Wisniewski Mary
- Wittekamp Bastiaan
- Wittenberg Wendy
- Wnuk Chris
- Woelke Amy
- Wong Jenny
- Wong Onyee
- Wood Erica
- Wood Hannah
- Wood Tracy
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- Woods Lindsey
- Woodward Robert
- Woolett Melissa
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wright Kim
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 nonâcritically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (nâ=â257), ARB (nâ=â248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; nâ=â10), or no RAS inhibitor (control; nâ=â264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ supportâfree days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ supportâfree days among critically ill patients was 10 (â1 to 16) in the ACE inhibitor group (nâ=â231), 8 (â1 to 17) in the ARB group (nâ=â217), and 12 (0 to 17) in the control group (nâ=â231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ supportâfree days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
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