Adaptive Ising Model and Bacterial Chemotactic Receptor Network

We present a so-called adaptive Ising model (AIM) to provide a unifying explanation for sensitivity and perfect adaptation in bacterial chemotactic signalling, based on coupling among receptor dimers. In an AIM, an external field, representing ligand binding, is randomly applied to a fraction of spins, representing the states of the receptor dimers, and there is a delayed negative feedback from the spin value on the local field. This model is solved in an adiabatic approach. If the feedback is slow and weak enough, as indeed in chemotactic signalling, the system evolves through quasi-equilibrium states and the ``magnetization'', representing the signal, always attenuates towards zero and is always sensitive to a subsequent stimulus.Comment: revtex, final version to appear in Europhysics Letter

Coupled Cluster Treatment of the XY model

We study quantum spin systems in the 1D, 2D square and 3D cubic lattices with nearest-neighbour XY exchange. We use the coupled-cluster method (CCM) to calculate the ground-state energy, the T=0 sublattice magnetisation and the excited state energies, all as functions of the anisotropy parameter $\gamma$. We consider $S=1/2$ in detail and give some results for higher $S$. In 1D these results are compared with the exact $S=1/2$ results and in 2D with Monte-Carlo and series expansions. We obtain critical points close to the expected value $\gamma=0$ and our extrapolated LSUBn results for the ground-state energy are well converged for all $\gamma$ except very close to the critical point.Comment: 11 pages, Latex, 4 postscript figure, accepted by J.Phys.: Condens. Matte

The economic potential for rainfed agrivoltaics in groundwater stressed regions

Agrivoltaics co-locate crops with solar photovoltaics (PV) to provide sustainability benefits across land, energy and water systems. Policies supporting a switch from irrigated farming to rainfed, grid-connected agrivoltaics in regions experiencing groundwater stress can mitigate both groundwater depletion and CO2 from electricity generation. Here, hydrology, crop, PV and financial models are integrated to assess the economic potential for rainfed agrivoltaics in groundwater stressed regions. The analysis reveals 11.2-37.6 PWh/yr of power generation potential, equivalent to 40-135% of the global electricity supply in 2018. Almost 90% of groundwater depletion in 2010 (~150 km3) occurred where the levelized cost for grid-connected rainfed agrivoltaic generation are 50-100 USD/MWh. Potential revenue losses following the switch from irrigated to rainfed crops represents 0-34% of the levelized generation cost. Future cost-benefit analysis must value the avoided groundwater stress from the perspective of long-term freshwater availability

Cost Effectiveness of a Community-Delivered Consultation to Improve Infant Sleep Problems and Maternal Well-Being

© 2018 Objectives: To evaluate the cost effectiveness of a community-delivered consultation aimed at improving infant sleep and maternal well-being. Methods: A decision-analytic model was developed that compared the costs and benefits of an infant sleep consultation with usual care. The effectiveness of the consultation was based on clinical evidence, and improvements in maternal quality of life were estimated by mapping the Edinburgh Postnatal Depression Scale scores to published utility scores. Cost effectiveness was calculated as the incremental cost per quality-adjusted life-year gained (QALY). Results: The statistically significant improvements in mean Edinburgh Postnatal Depression Scale scores at 4- and 16-month follow-ups were used to estimate the benefit in terms of QALYs. The modeled results demonstrated that the infant sleep consultation is low-cost (A$436), more effective in terms of QALYs gained (0.017), and cost-effective. The estimated incremental cost-effectiveness ratio was A$ 4031/QALY gained. The main drivers of the model were the use of early parenting centers and nurse training costs. Conclusions: Community-based nurse-delivered infant sleep consultations aid infant sleep, improve maternal quality of life, and are cost-effective compared with usual care and lead to improvements in quality of life through a reduction in postnatal depression

All-Solid-State Batteries Using Rationally Designed Garnet Electrolyte Frameworks

Functioning bulk-type all-solid-state batteries in a practical form factor with composite positive electrodes, using Al-substituted Li7La3Zr2O12 (LLZO) as the solid electrolyte, have been demonstrated for the first time. The devices incorporate bilayers composed of dense LLZO membranes and porous LLZO scaffolds infiltrated with LiNi0.6Mn0.2Co0.2O2 and other components as positive electrodes, combined with lithium anodes. The porous scaffolds are prepared using an easily scaled freeze-tape-casting method. The unidirectional pores of the scaffold facilitate infiltration of cathode components and shorten lithium ion diffusion path lengths, while the addition of a soft ionically conductive solid to the scaffold ensures good contact among the components

Bayesian analysis of Friedmannless cosmologies

Assuming only a homogeneous and isotropic universe and using both the 'Gold' Supernova Type Ia sample of Riess et al. and the results from the Supernova Legacy Survey, we calculate the Bayesian evidence of a range of different parameterizations of the deceleration parameter. We consider both spatially flat and curved models. Our results show that although there is strong evidence in the data for an accelerating universe, there is little evidence that the deceleration parameter varies with redshift.Comment: 7 pages, 3 figure

Compressive Phase Contrast Tomography

When x-rays penetrate soft matter, their phase changes more rapidly than their amplitude. In- terference effects visible with high brightness sources creates higher contrast, edge enhanced images. When the object is piecewise smooth (made of big blocks of a few components), such higher con- trast datasets have a sparse solution. We apply basis pursuit solvers to improve SNR, remove ring artifacts, reduce the number of views and radiation dose from phase contrast datasets collected at the Hard X-Ray Micro Tomography Beamline at the Advanced Light Source. We report a GPU code for the most computationally intensive task, the gridding and inverse gridding algorithm (non uniform sampled Fourier transform).Comment: 5 pages, "Image Reconstruction from Incomplete Data VI" conference 7800, SPIE Optical Engineering + Applications 1-5 August 2010 San Diego, CA United State

Clinical effectiveness and cost-effectiveness of pegvisomant for the treatment of acromegaly: a systematic review and economic evaluation

Background: Acromegaly, an orphan disease usually caused by a benign pituitary tumour, is characterised by hyper-secretion of growth hormone (GH) and insulin-like growth factor I (IGF-1). It is associated with reduced life expectancy, cardiovascular problems, a variety of insidiously progressing detrimental symptoms and metabolic malfunction. Treatments include surgery, radiotherapy and pharmacotherapy. Pegvisomant (PEG) is a genetically engineered GH analogue licensed as a third or fourth line option when other treatments have failed to normalise IGF-1 levels. Methods: Evidence about effectiveness and cost-effectiveness of PEG was systematically reviewed. Data were extracted from published studies and used for a narrative synthesis of evidence. A decision analytical economic model was identified and modified to assess the cost-effectiveness of PEG. Results: One RCT and 17 non-randomised studies were reviewed for effectiveness. PEG substantially reduced and rapidly normalised IGF-1 levels in the majority of patients, approximately doubled GH levels, and improved some of the signs and symptoms of the disease. Tumour size was unaffected at least in the short term. PEG had a generally safe adverse event profile but a few patients were withdrawn from treatment because of raised liver enzymes. An economic model was identified and adapted to estimate the lower limit for the cost-effectiveness of PEG treatment versus standard care. Over a 20 year time horizon the incremental cost-effectiveness ratio was pound81,000/QALY and pound212,000/LYG. To reduce this to pound30K/QALY would require a reduction in drug cost by about one third. Conclusion: PEG is highly effective for improving patients' IGF-1 level. Signs and symptoms of disease improve but evidence is lacking about long term effects on improved signs and symptoms of disease, quality of life, patient compliance and safety. Economic evaluation indicated that if current standards (UK) for determining cost-effectiveness of therapies were to be applied to PEG it would be considered not to represent good value for money

Structure and dynamics of the E. coli chemotaxis core signaling complex by cryo-electron tomography and molecular simulations

To enable the processing of chemical gradients, chemotactic bacteria possess large arrays of transmembrane chemoreceptors, the histidine kinase CheA, and the adaptor protein CheW, organized as coupled core-signaling units (CSU). Despite decades of study, important questions surrounding the molecular mechanisms of sensory signal transduction remain unresolved, owing especially to the lack of a high-resolution CSU structure. Here, we use cryo-electron tomography and sub-tomogram averaging to determine a structure of the Escherichia coli CSU at sub-nanometer resolution. Based on our experimental data, we use molecular simulations to construct an atomistic model of the CSU, enabling a detailed characterization of CheA conformational dynamics in its native structural context. We identify multiple, distinct conformations of the critical P4 domain as well as asymmetries in the localization of the P3 bundle, offering several novel insights into the CheA signaling mechanism