Immune- and nonimmune-compartment-specific interferon responses are critical determinants of herpes simplex virus-induced generalized infections and acute liver failure

The interferon (IFN) response to viral pathogens is critical for host survival. In humans and mouse models, defects in IFN responses can result in lethal herpes simplex virus 1 (HSV-1) infections, usually from encephalitis. Although rare, HSV-1 can also cause fulminant hepatic failure, which is often fatal. Although herpes simplex encephalitis has been extensively studied, HSV-1 generalized infections and subsequent acute liver failure are less well understood. We previously demonstrated that IFN-αβγR-/- mice are exquisitely susceptible to liver infection following corneal infection with HSV-1. In this study, we used bone marrow chimeras of IFN-αβγR-/- (AG129) and wild-type (WT; 129SvEv) mice to probe the underlying IFN-dependent mechanisms that control HSV-1 pathogenesis. After infection, WT mice with either IFN-αβγR-/- or WT marrow exhibited comparable survival, while IFN-αβγR-/- mice with WT marrow had a significant survival advantage over their counterparts with IFN-αβγR-/- marrow. Furthermore, using bioluminescent imaging to maximize data acquisition, we showed that the transfer of IFN-competent hematopoietic cells controlled HSV-1 replication and damage in the livers of IFN-αβγR-/- mice. Consistent with this, the inability of IFN-αβγR-/- immune cells to control liver infection in IFN-αβγR-/- mice manifested as profoundly elevated aspartate transaminase (AST) and alanine transaminase (ALT) levels, indicative of severe liver damage. In contrast, IFN-αβγR-/-mice receiving WT marrow exhibited only modest elevations of AST and ALT levels. These studies indicate that IFN responsiveness of the immune system is a major determinant of viral tropism and damage during visceral HSV infections

Planetary Nebula Surveys: Past, Present and Future

In this review we cover the detection, identification and astrophysical importance of planetary nebulae (PN). The legacy of the historic Perek & Kohoutek and Acker et al. catalogues is briefly covered before highlighting the more recent but significant progress in PN discoveries in our Galaxy and the Magellanic Clouds. We place particular emphasis on the major MASH and the IPHAS catalogues, which, over the last decade alone, have essentially doubled Galactic and LMC PN numbers. We then discuss the increasing role and importance that multi-wavelength data is playing in both the detection of candidate PN and the elimination of PN mimics that have seriously biased previous PN compilations. The prospects for future surveys and current efforts and prospects for PN detections in external galaxies are briefly discussed due to their value both as cosmic distance indicators and as kinematical probes of galaxies and dark matter properties.Comment: 8 pages, 1 figure, Proceedings of the Asymmetric Planetary Nebula V Conference (Invited Review, Lake District, England, June 2010

HASH: the Hong Kong/AAO/Strasbourg H-alpha planetary nebula database

By incorporating our major recent discoveries with re-measured and verified contents of existing catalogues we provide, for the first time, an accessible, reliable, on-line SQL database for essential, up-to date information for all known Galactic PNe. We have attempted to: i) reliably remove PN mimics/false ID's that have biased previous studies and ii) provide accurate positions, sizes, morphologies, multi-wavelength imagery and spectroscopy. We also provide a link to CDS/Vizier for the archival history of each object and other valuable links to external data. With the HASH interface, users can sift, select, browse, collate, investigate, download and visualise the entire currently known Galactic PNe diversity. HASH provides the community with the most complete and reliable data with which to undertake new science.Comment: 8 pages, 4 figures; accepted to appear in refereed proceedings of the 11th Pacific Rim Conference held in Hong-kong in Dec 201

Newly discovered halos and outer features around southern planetary nebulae

We have used the SuperCOSMOS H-alpha Survey to look for faint outer structures such as halos, ansae and jets around known planetary nebulae across 4000 square degrees of the southern Milky Way. Our search will contribute to a more accurate census of these features in the Galactic PN population. Candidate common-envelope PNe have also been identified on the basis of their microstructures. We also intend to determine more reliable distances for these PNe, which should allow a much better statistical basis for the post-AGB total mass budget. Our survey offers fresh scope to address this important issue.Comment: 2 pages, 1 figure. To be published in Planetary Nebulae: an Eye to the Future, Proceedings of IAU Symposium 283, held in Puerto de la Cruz, Tenerife, Spain, July 25-29 201

A catalogue of integrated H-alpha fluxes for 1,258 Galactic planetary nebulae

We present a catalogue of new integrated H-alpha fluxes for 1258 Galactic planetary nebulae (PNe), with the majority, totalling 1234, measured from the Southern H-Alpha Sky Survey Atlas (SHASSA) and/or the Virginia Tech Spectral-line Survey (VTSS). Aperture photometry on the continuum-subtracted digital images was performed to extract H-alpha + [NII] fluxes in the case of SHASSA, and H-alpha fluxes from VTSS. The [NII] contribution was then deconvolved from the SHASSA flux using spectrophotometric data taken from the literature or derived by us. Comparison with previous work shows that the flux scale presented here has no significant zero-point error. Our catalogue is the largest compilation of homogeneously derived PN fluxes in any waveband yet measured, and will be an important legacy and fresh benchmark for the community. Amongst its many applications, it can be used to determine statistical distances for these PNe, determine new absolute magnitudes for delineating the faint end of the PN luminosity function, provide baseline data for photoionization and hydrodynamical modelling, and allow better estimates of Zanstra temperatures for PN central stars with accurate optical photometry. We also provide total H-alpha fluxes for another 75 objects which were formerly classified as PNe, as well as independent reddening determinations for ~270 PNe, derived from a comparison of our H-alpha data with the best literature H-beta fluxes. In an appendix, we list corrected H-alpha fluxes for 49 PNe taken from the literature, including 24 PNe not detected on SHASSA or VTSS, re-calibrated to a common zero-point.Comment: 49 pages, 7 figures, 10 tables, to appear in MNRAS. This version includes full-length tables 1 and

The H\alpha\ surface brightness - radius relation: a robust statistical distance indicator for planetary nebulae

Measuring the distances to Galactic planetary nebulae (PNe) has been an intractable problem for many decades. We have now established a robust optical statistical distance indicator, the H$\alpha$ surface brightness- radius or S-r relation, which addresses this problem. We developed this relation from a critically evaluated sample of primary calibrating PNe. The robust nature of the method results from our revised calibrating distances with significantly reduced systematic uncertainties, and the recent availability of high-quality data, including updated nebular diameters and integrated H$\alpha$ fluxes. The S-r technique is simple in its application, requiring only an angular size, an integrated H\alpha\ flux, and the reddening to the PN. From these quantities, an intrinsic radius is calculated, which when combined with the angular size, yields the distance directly. Furthermore, we have found that optically thick PNe tend to populate the upper bound of the trend, while optically-thin PNe fall along the lower boundary in the S-r plane. This enables sub-trends to be developed which offer even better precision in the determination of distances, as good as 18 per cent in the case of optically-thin, high-excitation PNe. This is significantly better than any previous statistical indicator. We use this technique to create a catalogue of statistical distances for over 1100 Galactic PNe, the largest such compilation in the literature to date. Finally, in an appendix, we investigate both a set of transitional PNe and a range of PN mimics in the S-r plane, to demonstrate its use as a diagnostic tool. Interestingly, stellar ejecta around massive stars plot on a tight locus in S-r space with the potential to act as a separate distance indicator for these objects.Comment: 49 pages, 17 tables, 8 figures. Published in MNRAS; supplementary tables are included at end of this manuscrip

The Hα\alpha surface brightness −- radius plane as a diagnostic tool for photoionized nebulae

The H$\alpha$ surface brightness $-$ radius ($S-r$) relation is a robust distance indicator for planetary nebulae (PNe), further enhanced by different populations of PNe having distinct loci in $S-r$ space. Other types of photoionized nebulae also plot in quite distinct regions in the $S-r$ plane, allowing its use as a diagnostic tool. In particular, the nova shells and massive star ejecta (MSE) plot on relatively tight loci illustrating their evolutionary sequences. For the MSE, there is potential to develop a distance indicator for these objects, based on their trend in $S-r$ space. As high-resolution, narrowband surveys of the nearest galaxies become more commonplace, the $S-r$ plane is a potentially useful diagnostic tool to help identify the various ionized nebulae in these systems.Comment: 4 pages, 2 figures. To appear in the proceedings of the 11th Pacific Rim Conference on Stellar Astrophysics: Physics and Chemistry of the Late Stages of Stellar Evolution, held in Hong Kong, Dec 201