6,175 research outputs found
A Quantile Variant of the EM Algorithm and Its Applications to Parameter Estimation with Interval Data
The expectation-maximization (EM) algorithm is a powerful computational
technique for finding the maximum likelihood estimates for parametric models
when the data are not fully observed. The EM is best suited for situations
where the expectation in each E-step and the maximization in each M-step are
straightforward. A difficulty with the implementation of the EM algorithm is
that each E-step requires the integration of the log-likelihood function in
closed form. The explicit integration can be avoided by using what is known as
the Monte Carlo EM (MCEM) algorithm. The MCEM uses a random sample to estimate
the integral at each E-step. However, the problem with the MCEM is that it
often converges to the integral quite slowly and the convergence behavior can
also be unstable, which causes a computational burden. In this paper, we
propose what we refer to as the quantile variant of the EM (QEM) algorithm. We
prove that the proposed QEM method has an accuracy of while the MCEM
method has an accuracy of . Thus, the proposed QEM method
possesses faster and more stable convergence properties when compared with the
MCEM algorithm. The improved performance is illustrated through the numerical
studies. Several practical examples illustrating its use in interval-censored
data problems are also provided
Measurement and Particle Statistics in the Szilard Engine
A Szilard Engine is a hypothetical device which is able to extract work from
a single thermal reservoir by measuring the position of particles within the
engine. We derive the amount of work that can be extracted from such a device
in the low temperature limit. Interestingly, we show this work is determined by
the information gain of the initial measurement rather than by the number and
type of particles which constitute the working substance. Our work provides
another clear connection between information gain and extractable work in
thermodynamical processes.Comment: 4 page
A study on fire design accidental loads for aluminum safety helidecks
The helideck structure must satisfy the safety requirements associated with various environmental and accidental loads. Especially, there have been a number of fire accidents offshore due to helicopter collision (take-off and/or landing) in recent decades. To prevent further accidents, a substantial amount of effort has been directed toward the management of fire in the safety design of offshore helidecks. The aims of this study are to introduce and apply a procedure for quantitative risk assessment and management of fires by defining the fire loads with an applied example. The frequency of helicopter accidents are considered, and design accidental levels are applied. The proposed procedures for determining design fire loads can be efficiently applied in offshore helideck development projects
A Paclitaxel-Eluting Stent for the Prevention of Coronary Restenosis
Background Intimal hyperplasia and resulting restenosis limit the efficacy of coronary stenting. We studied a coronary stent coated with the antiproliferative agent paclitaxel as a means of preventing restenosis.
Methods We conducted a multicenter, randomized, controlled, triple-blind study to evaluate the ability of a paclitaxel-eluting stent to inhibit restenosis. At three centers, 177 patients with discrete coronary lesions (<15 mm in length, 2.25 to 3.5 mm in diameter) underwent implantation of paclitaxel-eluting stents (low dose, 1.3 µg per square millimeter, or high dose, 3.1 µg per square millimeter) or control stents. Antiplatelet therapies included aspirin with ticlopidine (120 patients), clopidogrel (18 patients), or cilostazol (37 patients). Clinical follow-up was performed at one month and four to six months, and angiographic follow-up at four to six months.
Results Technical success was achieved in 99 percent of the patients (176 of 177). At follow-up, the high-dose group, as compared with the control group, had significantly better results for the degree of stenosis (mean [±SD], 14±21 percent vs. 39±27 percent; P<0.001), late loss of luminal diameter (0.29±0.72 mm vs. 1.04±0.83 mm, P<0.001), and restenosis of more than 50 percent (4 percent vs. 27 percent, P<0.001). Intravascular ultrasound analysis demonstrated a dose-dependent reduction in the volume of intimal hyperplasia (31, 18, and 13 mm3, in the high-dose, low-dose, and control groups, respectively). There was a higher rate of major cardiac events in patients receiving cilostazol than in those receiving ticlopidine or clopidogrel. Among patients receiving ticlopidine or clopidogrel, event-free survival was 98 percent and 100 percent in the high-dose and control groups, respectively, at one month, and 96 percent in both at four to six months.
Conclusions Paclitaxel-eluting stents used with conventional antiplatelet therapy effectively inhibit restenosis and neointimal hyperplasia, with a safety profile similar to that of standard stents.published_or_final_versio
Pressure-dependent EPANET extension
In water distribution systems (WDSs), the available flow at a demand node is dependent on the pressure at that node. When a network is lacking in pressure, not all consumer demands will be met in full. In this context, the assumption that all demands are fully satisfied regardless of the pressure in the system becomes unreasonable and represents the main limitation of the conventional demand driven analysis (DDA) approach to WDS modelling. A realistic depiction of the network performance can only be attained by considering demands to be pressure dependent. This paper presents an extension of the renowned DDA based hydraulic simulator EPANET 2 to incorporate pressure-dependent demands. This extension is termed “EPANET-PDX” (pressure-dependent extension) herein. The utilization of a continuous nodal pressure-flow function coupled with a line search and backtracking procedure greatly enhance the algorithm’s convergence rate and robustness. Simulations of real life networks consisting of multiple sources, pipes, valves and pumps were successfully executed and results are presented herein. Excellent modelling performance was achieved for analysing both normal and pressure deficient conditions of the WDSs. Detailed computational efficiency results of EPANET-PDX with reference to EPANET 2 are included as well
In vivo characterization of early-stage radiation skin injury in a mouse model by two-photon microscopy
Ionizing radiation (IR) injury is tissue damage caused by high energy electromagnetic waves such as X-ray and gamma ray. Diagnosis and treatment of IR injury are difficult due to its characteristics of clinically latent post-irradiation periods and the following successive and unpredictable inflammatory bursts. Skin is one of the many sensitive organs to IR and bears local injury upon exposure. Early-stage diagnosis of IR skin injury is essential in order to maximize treatment efficiency and to prevent the aggravation of IR injury. In this study, early-stage changes of the IR injured skin at the cellular level were characterized in an in vivo mouse model by two-photon microscopy (TPM). Various IR doses were applied to the mouse hind limbs and the injured skin regions were imaged daily for 6 days after IR irradiation. Changes in the morphology and distribution of the epidermal cells and damage of the sebaceous glands were observed before clinical symptoms. These results showed that TPM is sensitive to early-stage changes of IR skin injury and may be useful for its diagnosis.1194Ysciescopu
Magnetic vortex oscillator driven by dc spin-polarized current
Transfer of angular momentum from a spin-polarized current to a ferromagnet
provides an efficient means to control the dynamics of nanomagnets. A peculiar
consequence of this spin-torque, the ability to induce persistent oscillations
of a nanomagnet by applying a dc current, has previously been reported only for
spatially uniform nanomagnets. Here we demonstrate that a quintessentially
nonuniform magnetic structure, a magnetic vortex, isolated within a nanoscale
spin valve structure, can be excited into persistent microwave-frequency
oscillations by a spin-polarized dc current. Comparison to micromagnetic
simulations leads to identification of the oscillations with a precession of
the vortex core. The oscillations, which can be obtained in essentially zero
magnetic field, exhibit linewidths that can be narrower than 300 kHz, making
these highly compact spin-torque vortex oscillator devices potential candidates
for microwave signal-processing applications, and a powerful new tool for
fundamental studies of vortex dynamics in magnetic nanostructures.Comment: 14 pages, 4 figure
Direct observation of a highly spin-polarized organic spinterface at room temperature
The design of large-scale electronic circuits that are entirely
spintronics-driven requires a current source that is highly spin-polarised at
and beyond room temperature, cheap to build, efficient at the nanoscale and
straightforward to integrate with semiconductors. Yet despite research within
several subfields spanning nearly two decades, this key building block is still
lacking. We experimentally and theoretically show how the interface between Co
and phthalocyanine molecules constitutes a promising candidate. Spin-polarised
direct and inverse photoemission experiments reveal a high degree of spin
polarisation at room temperature at this interface. We measured a magnetic
moment on the molecules's nitrogen pi orbitals, which substantiates an
ab-initio theoretical description of highly spin-polarised charge conduction
across the interface due to differing spinterface formation mechanims in each
spin channel. We propose, through this example, a recipe to engineer simple
organic-inorganic interfaces with remarkable spintronic properties that can
endure well above room temperature
Axially graded heteroepitaxy and Raman spectroscopic characterizations of Si1-xGex nanowires
We report the axially graded heteroepitaxy of Si1-xGex nanowires, by the kinetic controls of the Au-catalytic decomposition of precursors during chemical vapor syntheses. Transmission electron microscope studies demonstrate that the relative composition of Si and Ge is continuously graded along the uniformly thick nanowires, sharing the same crystal structures with the continuously varying lattices. We also employed a confocal Raman scattering imaging technique, and showed that the local variations in Raman phonon bands, specific to Si and Ge alloying (nu(Si-Si), nu(Si-Ge), and nu(Ge-Ge)), can be spatially and spectrally resolved along the individual nanowires, within the spatial resolution of similar to 500 nm. (c) 2008 American Institute of Physics.open111213Nsciescopu
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