Mapping Listvenite Occurrences in the Damage Zones of Northern Victoria Land, Antarctica Using ASTER Satellite Remote Sensing Data

Listvenites normally form during hydrothermal/metasomatic alteration of mafic and ultramafic rocks and represent a key indicator for the occurrence of ore mineralizations in orogenic systems. Hydrothermal/metasomatic alteration mineral assemblages are one of the significant indicators for ore mineralizations in the damage zones of major tectonic boundaries, which can be detected using multispectral satellite remote sensing data. In this research, Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) multispectral remote sensing data were used to detect listvenite occurrences and alteration mineral assemblages in the poorly exposed damage zones of the boundaries between the Wilson, Bowers and Robertson Bay terranes in Northern Victoria Land (NVL), Antarctica. Spectral information for detecting alteration mineral assemblages and listvenites were extracted at pixel and sub-pixel levels using the Principal Component Analysis (PCA)/Independent Component Analysis (ICA) fusion technique, Linear Spectral Unmixing (LSU) and Constrained Energy Minimization (CEM) algorithms. Mineralogical assemblages containing Fe 2+ , Fe 3+ , Fe-OH, Al-OH, Mg-OH and CO3 spectral absorption features were detected in the damage zones of the study area by implementing PCA/ICA fusion to visible and near infrared (VNIR) and shortwave infrared (SWIR) bands of ASTER. Silicate lithological groups were mapped and discriminated using PCA/ICA fusion to thermal infrared (TIR) bands of ASTER. Fraction images of prospective alteration minerals, including goethite, hematite, jarosite, biotite, kaolinite, muscovite, antigorite, serpentine, talc, actinolite, chlorite, epidote, calcite, dolomite and siderite and possible zones encompassing listvenite occurrences were produced using LSU and CEM algorithms to ASTER VNIR+SWIR spectral bands. Several potential zones for listvenite occurrences were identified, typically in association with mafic metavolcanic rocks (Glasgow Volcanics) in the Bowers Mountains.Comparison of the remote sensing results with geological investigations in the study area demonstrate invaluable implications of the remote sensing approach for mapping poorly exposed lithological units, detecting possible zones of listvenite occurrences and discriminating subpixel abundance of alteration mineral assemblages in the damage zones of the Wilson-Bowers and Bowers-Robertson Bay terrane boundaries and in intra-Bowers and Wilson terranes fault zones with high fluid flow. The satellite remote sensing approach developed in this research is explicitly pertinent to detecting key alteration mineral indicators for prospecting hydrothermal/metasomatic ore minerals in remote and inaccessible zones situated in other orogenic systems around the world

Intramembrane proteolysis of an extracellular serine protease, epithin/PRSS14, enables its intracellular nuclear function

Background Epithin/PRSS14, a type II transmembrane serine protease, is an emerging target of cancer therapy because of its critical roles in tumor progression and metastasis. In many circumstances, the protease, through its ectodomain shedding, exists as a soluble form and performs its proteolytic functions in extracellular environments increasing cellular invasiveness. The seemingly functional integrity of the soluble form raises the question of why the protease is initially made as a membrane-associated protein. Results In this report, we show that the epithin/PRSS14 intracellular domain (EICD) can be released from the membrane by the action of signal peptide peptidase-like 2b (SPPL2b) after ectodomain shedding. The EICD preferentially localizes in the nucleus and can enhance migration, invasion, and metastasis of epithelial cancer when heterologously expressed. Unbiased RNA-seq analysis and subsequent antibody arrays showed that EICD could control the gene expression of chemokines involved in cell motility, by increasing their promoter activities. Finally, bioinformatics analysis provided evidence for the clinical significance of the intramembrane proteolysis of epithin/PRSS14 by revealing that the poor survival of estrogen receptor (ER)-negative breast cancer patients with high epithin/PRSS14 expression is further worsened by high levels of SPPL2b. Conclusions These results show that ectodomain shedding of epithin/PRSS14 can initiate a unique and synchronized bidirectional signal for cancer metastasis: extracellularly broadening proteolytic modification of the surrounding environment and intracellularly reprogramming the transcriptome for metastatic conversion. Clinically, this study also suggests that the intracellular function of epithin/PRSS14 should be considered for targeting this protease for anti-cancer treatment.This work was supported in part by the National Research Foundation of Korea (NRF) grants (NRF-2017R1A2B4008109 to M.G.K. and NRF2019R1A2C2008067 to C.K.) and a Korea University grant (to C.K.)

The efficacy and safety study of dietary supplement PURIAM110 on non-insulin taking Korean adults in the stage of pre-diabetes and diabetes mellitus: protocol for a randomized, double-blind, placebo-controlled, and multicenter trial-pilot study

<p>Abstract</p> <p>Background</p> <p>Diabetes has already become a threat to the nation and the individual due to its high prevalence rates and high medical expenses. Therefore, preventing diabetes at an earlier stage is very important. Despite advances in antidiabetic agents, we have not yet achieved any satisfying results in treating diabetes. Among various treatments, medicinal herbs and supplements for diabetes are reported to show generally good efficacy and safety data. In particular, PURIAM110, a compound from orange fruits and mulberry leaves, is supposed to prevent the progress of type II diabetes mellitus and improve diabetic symptoms. This is the first reported pilot study about the protective effect of the orange fruits and mulberry leaves mixture against pre-diabetes on Korean adults. Based on these positive results of herb-derived components, extended studies of dietary supplements have to be done to suggest confirmative evidences.</p> <p>Methods/Design</p> <p>The efficacy and safety study of PURIAM110 is a double-blinded, placebo-controlled, randomized, and multi-center clinical trial. A total of 45 subjects will participate in this study for 6 weeks.</p> <p>Discussion</p> <p>The present protocol will confirm the efficacy and safety of PURIAM110 for pre-diabetes, suggesting more basic knowledge to conduct further randomized controlled trials (RCT). In addition, PURIAM110 can be an alternative dietary supplemental remedy for diabetes patients.</p> <p>Trial Registration</p> <p>ISRCTN: <a href="http://www.controlled-trials.com/ISRCTN44779824">ISRCTN44779824</a></p

A pilot study to evaluate the effect of Taeumjowi-tang on obesity in Korean adults: study protocol for a randomised, double-blind, placebo-controlled, multicentre trial

<p>Abstract</p> <p>Background</p> <p>Obesity, which is described as excessive or abnormal body fat, increases the risk of diet-related diseases. In Korea and around the world, the prevalence of obesity has grown annually from 1998 to 2008. This growth has continued despite various therapeutic efforts. The discovery of new and alternative treatments for obesity should be considered an important priority. Taeumjowi-tang (TJ001), a traditional Korean medicinal extract consisting of eight herbs, is a widely used herbal remedy for obesity in Korea. However, the efficacy and safety of TJ001 have not been fully investigated in a clinical trial. The purpose of this pilot study is to estimate obesity-related parameters and to assess the efficacy and safety of TJ001.</p> <p>Methods</p> <p>Our study is a randomised, double-blind, placebo-controlled, multicentre clinical trial of Taeumjowi-tang (TJ001). For this study, we will recruit obese Korean patients of both sexes, ages 18 to 65 years, from four university hospitals. A total of 104 subjects will be recruited. The participants will receive either 7 g of TJ001 or a placebo three times daily for 12 weeks. The primary end point will be the rate of subjects who lose at least 5% of their baseline body weight. The secondary end points will be changes in body weight, body mass index, waist circumference, hip circumference, waist/hip circumference ratio, lipid profiles, body fat composition, blood pressure, fasting glucose concentration, C-reactive protein and questionnaires related to the quality of life. The outcomes will be measured every 4 weeks. The study period will be 12 weeks and will include a total of five visits with each subject (at screening and at 0, 4, 8 and 12 weeks).</p> <p>Conclusions</p> <p>The results of our study will inform various estimates of TJ001 and will serve as the basis for a larger-scale trial. This study will assess the efficacy and safety of TJ001 as an alternative herbal remedy for obesity.</p> <p>Trial registration</p> <p>Current Controlled Trials <a href="http://www.controlled-trials.com/ISRCTN87153759">ISRCTN87153759</a></p

Dataset on electro-optically tunable smart-supercapacitors based on oxygen-excess nanograin tungsten oxide thin film

The dataset presented here is related to the research article entitled ???Highly Efficient Electro-optically Tunable Smart-supercapacitors Using an Oxygen-excess Nanograin Tungsten Oxide Thin Film??? (Akbar et al., 2017) [9] where we have presented a nanograin WO3 film as a bifunctional electrode for smart supercapacitor devices. In this article we provide additional information concerning nanograin tungsten oxide thin films such as atomic force microscopy, Raman spectroscopy, and X-ray diffraction spectroscopy. Moreover, their electrochemical properties such as cyclic voltammetry, electrochemical supercapacitor properties, and electrochromic properties including coloration efficiency, optical modulation and electrochemical impedance spectroscopy are presented

All-Arthroscopic Knotless Suture Anchor Repair of Triangular Fibrocartilage Complex Fovea Tear by the 2-Portal Technique

After the importance of the deep fiber of the distal radioulnar ligament had been acknowledged, some repair techniques have been introduced. Because the knotless suture anchor does not cause any knot irritation and yields appropriate tension, it is a useful fixation material. All-arthroscopic knotless suture anchor repair of the triangular fibrocartilage complex fovea tear by a 2-portal technique is easier and less vulnerable to ulnar nerve injury than the original Geissler technique. Instead of the suture hook and accessory portal, this technique uses the always-sharp 18-gauge needle and percutaneous route. This change results in the repair of the complex fovea tear having the smallest possible remnant tissue. Repair of triangular fibrocartilage complex fovea tears combined type IB, ID, and IIC tears can reduce the chance of needing to perform distal radioulnar ligament reconstruction

Development of Hierarchical Structure System for Real-time Generation of Large Terrain Data Sets

ABSTRACT Recently, we are making quick acquisition of huge geographical feature information data by rapid measurement and development of satellite information technique. We expect the geographical feature information to be acquired; to be analyzed accurately to minimize data loss and massive data volume visualization to be executed. We require the technique which the user makes is possible for reality world immersion. We are applying the LOD (Level of Detail) algorithm to point key element for visualization execution. To accomplish detail level decision considers to user view, immediate utility is impossible a source data (DEM), and we need a factor overlay decision which is hierarchy based on users view. In this research, to acquire the thorn of massive volume DEM, we choose the 4X4 tile hierarchy or 2X2 structure. To express user center terrain information for real sense, we apply DEM and produce Hill Shading Image. Terrain blocks file is produced to hierarchy tile structure. We transform terrain data to various factors overlay. Connect this by the hierarchy each other. We express a factor overlay change in the height quality, follow, minimize data loss and try to do a frame speed