3,094 research outputs found
Quantization of anomaly coefficients in 6D supergravity
We obtain new constraints on the anomaly coefficients of 6D
supergravity theories using local and global anomaly
cancellation conditions. We show how these constraints can be strengthened if
we assume that the theory is well-defined on any spin space-time with an
arbitrary gauge bundle. We distinguish the constraints depending on the gauge
algebra only from those depending on the global structure of the gauge group.
Our main constraint states that the coefficients of the anomaly polynomial for
the gauge group should be an element of where is the unimodular string charge lattice. We show
that the constraints in their strongest form are realized in F-theory
compactifications. In the process, we identify the cocharacter lattice, which
determines the global structure of the gauge group, within the homology lattice
of the compactification manifold.Comment: 42 pages. v3: Some clarifications, typos correcte
A Multi-Code Analysis Toolkit for Astrophysical Simulation Data
The analysis of complex multiphysics astrophysical simulations presents a
unique and rapidly growing set of challenges: reproducibility, parallelization,
and vast increases in data size and complexity chief among them. In order to
meet these challenges, and in order to open up new avenues for collaboration
between users of multiple simulation platforms, we present yt (available at
http://yt.enzotools.org/), an open source, community-developed astrophysical
analysis and visualization toolkit. Analysis and visualization with yt are
oriented around physically relevant quantities rather than quantities native to
astrophysical simulation codes. While originally designed for handling Enzo's
structure adaptive mesh refinement (AMR) data, yt has been extended to work
with several different simulation methods and simulation codes including Orion,
RAMSES, and FLASH. We report on its methods for reading, handling, and
visualizing data, including projections, multivariate volume rendering,
multi-dimensional histograms, halo finding, light cone generation and
topologically-connected isocontour identification. Furthermore, we discuss the
underlying algorithms yt uses for processing and visualizing data, and its
mechanisms for parallelization of analysis tasks.Comment: 18 pages, 6 figures, emulateapj format. Resubmitted to Astrophysical
Journal Supplement Series with revisions from referee. yt can be found at
http://yt.enzotools.org
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Application of change point analysis to daily influenza-like illness emergency department visits
Background: The utility of healthcare utilization data from US emergency departments (EDs) for rapid monitoring of changes in influenza-like illness (ILI) activity was highlighted during the recent influenza A (H1N1) pandemic. Monitoring has tended to rely on detection algorithms, such as the Early Aberration Reporting System (EARS), which are limited in their ability to detect subtle changes and identify disease trends. Objective: To evaluate a complementary approach, change point analysis (CPA), for detecting changes in the incidence of ED visits due to ILI. Methodology and principal findings Data collected through the Distribute project (isdsdistribute.org), which aggregates data on ED visits for ILI from over 50 syndromic surveillance systems operated by state or local public health departments were used. The performance was compared of the cumulative sum (CUSUM) CPA method in combination with EARS and the performance of three CPA methods (CUSUM, structural change model and Bayesian) in detecting change points in daily time-series data from four contiguous US states participating in the Distribute network. Simulation data were generated to assess the impact of autocorrelation inherent in these time-series data on CPA performance. The CUSUM CPA method was robust in detecting change points with respect to autocorrelation in time-series data (coverage rates at 90% when â0.2â¤Ďâ¤0.2 and 80% when â0.5â¤Ďâ¤0.5). During the 2008â9 season, 21 change points were detected and ILI trends increased significantly after 12 of these change points and decreased nine times. In the 2009â10 flu season, we detected 11 change points and ILI trends increased significantly after two of these change points and decreased nine times. Using CPA combined with EARS to analyze automatically daily ED-based ILI data, a significant increase was detected of 3% in ILI on April 27, 2009, followed by multiple anomalies in the ensuing days, suggesting the onset of the H1N1 pandemic in the four contiguous states. Conclusions and significance As a complementary approach to EARS and other aberration detection methods, the CPA method can be used as a tool to detect subtle changes in time-series data more effectively and determine the moving direction (ie, up, down, or stable) in ILI trends between change points. The combined use of EARS and CPA might greatly improve the accuracy of outbreak detection in syndromic surveillance systems
Geographic constraints on social network groups
Social groups are fundamental building blocks of human societies. While our
social interactions have always been constrained by geography, it has been
impossible, due to practical difficulties, to evaluate the nature of this
restriction on social group structure. We construct a social network of
individuals whose most frequent geographical locations are also known. We also
classify the individuals into groups according to a community detection
algorithm. We study the variation of geographical span for social groups of
varying sizes, and explore the relationship between topological positions and
geographic positions of their members. We find that small social groups are
geographically very tight, but become much more clumped when the group size
exceeds about 30 members. Also, we find no correlation between the topological
positions and geographic positions of individuals within network communities.
These results suggest that spreading processes face distinct structural and
spatial constraints.Comment: 10 pages, 5 figure
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Bayes Wars Redivivus - An Exchange
An electronic exchange among 10 evidence scholars that began with a discussion of the restyled Federal Rules and grew into a significant restatement of debates in evidentiary scholarship over the last 50 years, touching on relevance, probative value, inference, Bayesianism and the foundations of evidence, with an introduction by Michael Risinger
Single-Mode Squeezed Light Generation and Tomography with an Integrated Optical Parametric Oscillator
Quantum optical technologies promise advances in sensing, computing, and
communication. A key resource is squeezed light, where quantum noise is
redistributed between optical quadratures. We introduce a monolithic,
chip-scale platform that exploits the nonlinearity of a thin-film
lithium niobate (TFLN) resonator device to efficiently generate squeezed states
of light. Our system integrates all essential components -- except for the
laser and two detectors -- on a single chip with an area of one square
centimeter, significantly reducing the size, operational complexity, and power
consumption associated with conventional setups. Our work addresses challenges
that have limited previous integrated nonlinear photonic implementations that
rely on either nonlinear resonators or on integrated waveguide
parametric amplifiers. Using the balanced homodyne measurement
subsystem that we implemented on the same chip, we measure a squeezing of 0.55
dB and an anti-squeezing of 1.55 dB. We use 20 mW of input power to generate
the parametric oscillator pump field by employing second harmonic generation on
the same chip. Our work represents a substantial step toward compact and
efficient quantum optical systems posed to leverage the rapid advances in
integrated nonlinear and quantum photonics.Comment: 21 pages; 4 figures in main body, 8 supplementary figure
Gravitational Instantons and Moduli Spaces of Topological 2-form Gravity
A topological version of four-dimensional (Euclidean) Einstein gravity which
we propose regards anti-self-dual 2-forms and an anti-self-dual part of the
frame connections as fundamental fields. The theory describes the moduli spaces
of conformally self-dual Einstein manifolds for the non-zero cosmological
constant case and Einstein-Kahlerian manifold with the vanishing real first
Chern class for the zero cosmological constant. In the non-zero cosmological
constant case, we evaluate the index of the elliptic complex associated with
the moduli space and calculate the partition function. We also clarify the
moduli space and its dimension for the zero cosmological constant case which
are related to the Plebansky's heavenly equations.Comment: 36pages, LaTex, TIT/HEP-247/COSMO-4
Accuracy of 23 Equations for Estimating LDL Cholesterol in a Clinical Laboratory Database of 5,051,467 Patients
Background: Alternatives to the Friedewald low-density lipoprotein cholesterol (LDL-C) equation have been proposed. Objective: To compare the accuracy of available LDL-C equations with ultracentrifugation measurement. Methods: We used the second harvest of the Very Large Database of Lipids (VLDbL), which is a population-representative convenience sample of adult and pediatric patients (N = 5,051,467) with clinical lipid measurements obtained via the vertical auto profile (VAP) ultracentrifugation method between October 1, 2015 and June 30, 2019. We performed a systematic literature review to identify available LDL-C equations and compared their accuracy according to guideline-based classification. We also compared the equations by their median error versus ultracentrifugation. We evaluated LDL-C equations overall and stratified by age, sex, fasting status, and triglyceride levels, as well as in patients with atherosclerotic cardiovascular disease, hypertension, diabetes, kidney disease, inflammation, and thyroid dysfunction. Results: Analyzing 23 identified LDL-C equations in 5,051,467 patients (meanÂąSD age, 56Âą16 years; 53.3% women), the Martin/Hopkins equation most accurately classified LDL-C to the correct category (89.6%), followed by the Sampson (86.3%), Chen (84.4%), Puavilai (84.1%), Delong (83.3%), and Friedewald (83.2%) equations. The other 17 equations were less accurate than Friedewald, with accuracy as low as 35.1%. The median error of equations ranged from â10.8 to 18.7 mg/dL, and was best optimized using the Martin/Hopkins equation (0.3, IQRâ1.6 to 2.4 mg/dL). The Martin/Hopkins equation had the highest accuracy after stratifying by age, sex, fasting status, triglyceride levels, and clinical subgroups. In addition, one in five patients who had Friedewald LDL-C 70 mg/dL by the Martin/Hopkins equation. Conclusions: Most proposed alternatives to the Friedewald equation worsen LDL-C accuracy, and their use could introduce unintended disparities in clinical care. The Martin/Hopkins equation demonstrated the highest LDL-C accuracy overall and across subgroups
Trends in weight gain recorded in English primary care before and during the Coronavirus-19 pandemic: An observational cohort study using the OpenSAFELY platform.
BACKGROUND: Obesity and rapid weight gain are established risk factors for noncommunicable diseases and have emerged as independent risk factors for severe disease following Coronavirus Disease 2019 (COVID-19) infection. Restrictions imposed to reduce COVID-19 transmission resulted in profound societal changes that impacted many health behaviours, including physical activity and nutrition, associated with rate of weight gain. We investigated which clinical and sociodemographic characteristics were associated with rapid weight gain and the greatest acceleration in rate of weight gain during the pandemic among adults registered with an English National Health Service (NHS) general practitioner (GP) during the COVID-19 pandemic. METHODS AND FINDINGS: With the approval of NHS England, we used the OpenSAFELY platform inside TPP to conduct an observational cohort study of routinely collected electronic healthcare records. We investigated changes in body mass index (BMI) values recorded in English primary care between March 2015 and March 2022. We extracted data on 17,742,365 adults aged 18 to 90 years old (50.1% female, 76.1% white British) registered with an English primary care practice. We estimated individual rates of weight gain before (δ-prepandemic) and during (δ-pandemic) the pandemic and identified individuals with rapid weight gain (>0.5 kg/m2/year) in each period. We also estimated the change in rate of weight gain between the prepandemic and pandemic period (δ-change = δ-pandemic-δ-prepandemic) and defined extreme accelerators as the 10% of individuals with the greatest increase in their rate of weight gain (δ-change âĽ1.84 kg/m2/year) between these periods. We estimated associations with these outcomes using multivariable logistic regression adjusted for age, sex, index of multiple deprivation (IMD), and ethnicity. P-values were generated in regression models. The median BMI of our study population was 27.8 kg/m2, interquartile range (IQR) [24.3, 32.1] in 2019 (March 2019 to February 2020) and 28.0 kg/m2, IQR [24.4, 32.6] in 2021. Rapid pandemic weight gain was associated with sex, age, and IMD. Male sex (male versus female: adjusted odds ratio (aOR) 0.76, 95% confidence interval (95% CI) [0.76, 0.76], p < 0.001), older age (e.g., 50 to 59 years versus 18 to 29 years: aOR 0.60, 95% CI [0.60, 0.61], p < 0.001]); and living in less deprived areas (least-deprived-IMD-quintile versus most-deprived: aOR 0.77, 95% CI [0.77, 0.78] p < 0.001) reduced the odds of rapid weight gain. Compared to white British individuals, all other ethnicities had lower odds of rapid pandemic weight gain (e.g., Indian versus white British: aOR 0.69, 95% CI [0.68, 0.70], p < 0.001). Long-term conditions (LTCs) increased the odds, with mental health conditions having the greatest effect (e.g., depression (aOR 1.18, 95% CI [1.17, 1.18], p < 0.001)). Similar characteristics increased odds of extreme acceleration in the rate of weight gain between the prepandemic and pandemic periods. However, changes in healthcare activity during the pandemic may have introduced new bias to the data. CONCLUSIONS: We found female sex, younger age, deprivation, white British ethnicity, and mental health conditions were associated with rapid pandemic weight gain and extreme acceleration in rate of weight gain between the prepandemic and pandemic periods. Our findings highlight the need to incorporate sociodemographic, physical, and mental health characteristics when formulating research, policies, and interventions targeting BMI in the period of post pandemic service restoration and in future pandemic planning
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