Conditions for Generic Initial Ideals to be Almost Reverse Lexicographic

Let $I$ be a homogeneous Artinian ideal in a polynomial ring $R=k[x_1,...,x_n]$ over a field $k$ of characteristic 0. We study an equivalent condition for the generic initial ideal \gin(I) with respect to reverse lexicographic order to be almost reverse lexicographic. As a result, we show that Moreno-Socias conjecture implies Fr\"{o}berg conjecture. And for the case \Codim I \le 3, we show that $R/I$ has the strong Lefschetz property if and only if \gin(I) is almost reverse lexicographic. Finally for a monomial complete intersection Artinian ideal $I=(x_1^{d_1},...,x_n^{d_n})$, we prove that \gin(I) is almost reverse lexicographic if $d_i > \sum_{j=1}^{i-1} d_j - i + 1$ for each $i \ge 4$. Using this, we give a positive partial answer to Moreno-Socias conjecture, and to Fr\"{o}berg conjecture.Comment: 10 page

How donor's regulatory focus changes the effectiveness of a sadness-evoking charity appeal

Past research offers conflicting findings on whether sadness-evoking charity appeals help solicit a donation. To reconcile these findings, we introduce prospective donors' regulatory focus as a moderator for understanding when and why sadness appeals motivate or demotivate giving. Specifically, we propose that the sense of helplessness or loss of control associated with sadness appeals increases donors' sensitivity to advertiser's manipulative persuasion tactics, as those tactics can threaten donors' control over their donation decision. As a result, sadness appeals are more likely to activate persuasion knowledge among prevention- (vs. promotion-) oriented donors who tend to be vigilant against manipulative persuasion attempts. Across six main studies and two supplementary studies, we find that a prevention (vs. promotion) focus discourages charitable giving when it is solicited using a sadness appeal, whereas regulatory focus does not affect the giving when other emotion appeals (e.g., happiness appeal or guilt appeal) are used. We find that a prevention (vs. promotion) focus demotivates donation solicited by a sadness appeal because it activates persuasion knowledge that evaluates solicitor's motive behind the sadness appeal, resulting in increased skepticism, dampened feelings of sympathy, and consequently, reduced charitable giving. However, when persuasion knowledge is deactivated (e.g., when donors' cognitive capacity is constrained or the soliciting charity has a reliable reputation), regulatory focus no longer affects donor skepticism, sympathy, and charitable giving, even when a sadness appeal is used to call for donation

Block Design-Based Local Differential Privacy Mechanisms

In this paper, we propose a new class of local differential privacy (LDP) schemes based on combinatorial block designs for a discrete distribution estimation. This class not only recovers many known LDP schemes in a unified framework of combinatorial block design, but also suggests a novel way of finding new schemes achieving the optimal (or near-optimal) privacy-utility trade-off with lower communication costs. Indeed, we find many new LDP schemes that achieve both the optimal privacy-utility trade-off and the minimum communication cost among all the unbiased schemes for a certain set of input data size and LDP constraint. Furthermore, to partially solve the sparse existence issue of block design schemes, we consider a broader class of LDP schemes based on regular and pairwise-balanced designs, called RPBD schemes, which relax one of the symmetry requirements on block designs. By considering this broader class of RPBD schemes, we can find LDP schemes achieving near-optimal privacy-utility trade-off with reasonably low communication costs for a much larger set of input data size and LDP constraint.Comment: 18 pages, 3 figures, and 1 table. This manuscript was submitted to IEEE Transactions on Information Theory and a short version of this manuscript will be presented at 2023 IEEE International Symposium on Information Theor

Pain Management of Herpes Zoster

Herpes zoster (HZ) is a disease triggered by the reactivation of latent varicella zoster virus (VZV) in spinal or cranial sensory ganglia, and is characterized by a painful vesicular eruption in the affected dermatome. Postherpetic neuralgia (PHN) is a chronic, neuropathic pain that can persist long beyond resolution of visible cutaneous manifestations which is often resistant to current analgesic treatments. The lifetime prevalence of herpes zoster is approximately 20–30% and about 9–34% of these patients develop PHN depending on its definition. Clinical experience has shown that PHN often develops in cases of inadequate initial pain management resulting in increased pain intensity. This review provides an overview of the treatment options for HZ and PHN, focusing on the therapeutic modalities of pain management. The primary objectives of management of HZ are to inhibit viral replication, relieve pain, and prevent associated complications, such as PHN. General treatments for acute HZ are combination of antiviral therapy with a short course of corticosteroids at the onset of the disease in conjunction with an effective control of acute pain, including nonsteroidal anti-inflammatory drugs, acetaminophen, opioids, and anticonvulsants such as gabapentin or pregabalin. Treatment of PHN is often resistant to the current pharmacologic methods. Therefore, a multimodal analgesic treatment regimen including topical lidocaine and capsaicin, systemic therapies, and the interventional treatments is necessary to alleviate pain and its effect on quality of life. As the incidence of HZ increases with age, the number of patients with HZ and PHN may increase in the future considering the gradual aging of the general population. Appropriate management of HZ can reduce the duration and intensity of pain from HZ, and prevent the development of PHN. In addition, prophylactic zoster vaccination can prevent or reduce the incidence of HZ and PHN. Further efforts are needed to minimize pain of the patients suffering from HZ and PHN as it affects the quality of life in the aspect of both physical and psychological impairments

Anti-inflammatory effects of spermidine in lipopolysaccharide-stimulated BV2 microglial cells

<p>Abstract</p> <p>Background</p> <p>Spermidine, a naturally occurring polyamine, displays a wide variety of internal biological activities including cell growth and proliferation. However, the molecular mechanisms responsible for its anti-inflammatory activity have not yet been elucidated.</p> <p>Methods</p> <p>The anti-inflammatory properties of spermidine were studied using lipopolysaccharide (LPS)-stimulated murine BV2 microglia model. As inflammatory parameters, the production of nitric oxide (NO), prostaglandin E₂(PGE₂), interleukin (IL)-6 and tumor necrosis factor (TNF)-α were evaluated. We also examined the spermidine's effect on the activity of nuclear factor-kappaB (NF-κB), and the phosphoinositide 3-kinase (PI3K)/Akt and mitogen-activated protein kinases (MAPKs) pathways.</p> <p>Results</p> <p>Pretreatment with spermidine prior to LPS treatment significantly inhibited excessive production of NO and PGE₂in a dose-dependent manner, and was associated with down-regulation of expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Spermidine treatment also attenuated the production of pro-inflammatory cytokines, including IL-6 and TNF-α, by suppressing their mRNA expressions. The mechanism underlying spermidine-mediated attenuation of inflammation in BV2 cells appeared to involve the suppression of translocation of NF-κB p65 subunit into the nucleus, and the phosphorylation of Akt and MAPKs.</p> <p>Conclusions</p> <p>The results indicate that spermidine appears to inhibit inflammation stimulated by LPS by blocking the NF-κB, PI3K/Akt and MAPKs signaling pathways in microglia.</p

Increased Prevalence of low High-density Lipoprotein Cholesterol (HDL-C) Levels in Korean Adults: Analysis of the Three Korean National Health and Nutrition Examination Surveys (KNHANES 1998–2005)

AbstractObjectivesHigh-density lipoprotein cholesterol (HDL-C) is an independent risk factor for cardiovascular diseases that has shown a remarkable increase, but little is known about the prevalence of low HDL-C in Korea. This study aimed to evaluate changing trends of low HDL-C prevalence, and indicate other risk factors associated with low HDL-C.MethodsWe selected subjects aged ≥20 years from the Korean National Health and Nutrition Examination Survey (KNHANES) 1998, 2001, and 2005 (n = 7962, 6436, and 6412). The mean level of HDL-C and the prevalence of low HDL-C was calculated, and cardiovascular risk factors associated with low HDL-C, as well as demographic, anthropometric, lifestyle, and nutrition factors, were assessed using the KNHANES 2005 data.ResultsMean HDL-C levels in men and women between KNHANES 1998 and 2005 decreased significantly, from 48.1 to 42.3 and from 51.6 to 47.1 mg/dL, respectively (both p < 0.001). The decrease was slightly less for women compared with men for the same period, and women had higher HDL-C levels at all periods. Covariate-adjusted OR revealed that body mass index, waist circumference, and non-alcohol drinker in both men and women were associated with low HDL-C levels by KNHANES 2005, as were employed and light physical activity in men and low fat intake in women.ConclusionThe prevalence of low HDL-C increased significantly from KNHANES 1998 to 2001 and 2005 (p < 0.001) in both men and women. body mass index, waist circumference, and non-alcohol drinker were identified as associated with low HDL-C in Korean adults

Nano-mechanical behavior of ultra-stable amorphous metallic thin films

Metallic glass has amorphous structure that behave mechanically like solids but show catastrophic failure due to shear band propagation induced by short range order structure, and they are generally produced by quenching. Recently, it is observed that the slower cooling rate provides the larger time available for atoms to rearrange structure before freezing in glassy state, leading to glass transition temperature and thermal stability. These glasses with enhanced thermal stability synthesized by controlled cooling rate make it useful in various field such as mechanical or oxidation protection material. However, mechanical behavior for metallic glass with extraordinary thermodynamic and kinetic stability has not been studied. In this research, we developed a ultrastable metallic glass thin film by physical vapor deposition process at ambient temperature. Thermal stability is investigated using acceleration testing. Mechanical properties are measured using in-situ tensile testing and discuss thermal stability and fracture behavior dependent on compositio

An Exploratory Study on the Association Between Social Capital and Self-Rated Health of South Korean Women with Disabilities

The purpose of this chapter was to explore the relationship between social capital and self-rated health status as assessed in the activities of the everyday life of South Korean women with disabilities. For this purpose, the authors analyzed the 8th data of the panel survey of employment for the disabled (PSED) that included a sample of 275 women with disabilities who are paid worker. The authors found that working environment, working hours, personal development possibilities, communication-and interpersonal-relationships, the fairness of performance assessment, welfare benefits, training opportunities, and job satisfaction differed significantly in relation to the self-rated health status of women with disabilities. The authors also found that for working hours, communication, and interpersonal relationships, significantly higher self-rated health status was found for satisfied compared to the satisfaction group. For personal development possibilities, welfare benefits, and training opportunities, self-rated health status was significantly higher for the satisfaction group than the dissatisfied group. For fairness of the performance assessment, self-rated health status of the satisfaction group was significantly higher than in the dissatisfied and the normal group. Therefore, in order to improve the self-rated health of South Korean women with disabilities, it is necessary to provide working environment considering their disability characteristics and various training opportunities in their workplace