6 research outputs found
A dynamic network analysis of emergent grammar
For languages to survive as complex cultural systems, they need to be learnable. According to traditional approaches, learning is made possible by constraining the degrees of freedom in advance of experience and by the construction of complex structure during development. This article explores a third contributor to complexity: namely, the extent to which syntactic structure can be an emergent property of how simpler entities – words – interact with one another. The authors found that when naturalistic child directed speech was instantiated in a dynamic network, communities formed around words that were more densely connected with other words than they were with the rest of the network. This process is designed to mirror what we know about distributional patterns in natural language: namely, the network communities represented the syntactic hubs of semi-formulaic slot-and-frame patterns, characteristic of early speech. The network itself was blind to grammatical information and its organization reflected (a) the frequency of using a word and (b) the probabilities of transitioning from one word to another. The authors show that grammatical patterns in the input disassociate by community structure in the emergent network. These communities provide coherent hubs which could be a reliable source of syntactic information for the learner. These initial findings are presented here as proof-of-concept in the hope that other researchers will explore the possibilities and limitations of this approach on a larger scale and with more languages. The implications of a dynamic network approach are discussed for the learnability burden and the development of an adult-like grammar
Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males
Abstract
Painful temporomandibular disorders (TMDs) are the leading cause of chronic orofacial pain, but its underlying molecular mechanisms remain obscure. Although many environmental factors have been associated with higher risk of developing painful TMD, family and twin studies support a heritable genetic component as well. We performed a genome-wide association study assuming an additive genetic model of TMD in a discovery cohort of 999 cases and 2031 TMD-free controls from the Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA) study. Using logistic models adjusted for sex, age, enrollment site, and race, we identified 3 distinct loci that were significant in combined or sex-segregated analyses. A single-nucleotide polymorphism on chromosome 3 (rs13078961) was significantly associated with TMD in males only (odds ratio = 2.9, 95% confidence interval: 2.02–4.27, P = 2.2 × 10⁻⁸). This association was nominally replicated in a meta-analysis of 7 independent orofacial pain cohorts including 160,194 participants (odds ratio = 1.16, 95% confidence interval: 1.0–1.35, P = 2.3 × 10⁻²). Functional analysis in human dorsal root ganglia and blood indicated this variant is an expression quantitative trait locus, with the minor allele associated with decreased expression of the nearby muscle RAS oncogene homolog (MRAS) gene (beta = −0.51, P = 2.43 × 10⁻⁵). Male mice, but not female mice, with a null mutation of Mras displayed persistent mechanical allodynia in a model of inflammatory pain. Genetic and behavioral evidence support a novel mechanism by which genetically determined MRAS expression moderates the resiliency to chronic pain. This effect is male-specific and may contribute to the lower rates of painful TMD in men