Nanoemulsion as potential vehicles for transdermal delivery of pure phytopharmaceuticals and poorly soluble drug

Nanoemulsion (NE) is defined as an O/W or W/O emulsion producing a transparent product that has a droplet size from 20-200nm and does not have the tendency to coalesce. It is promising for transdermal delivery of drugs as an efficient route of drug administration. Several mechanisms have been proposed to explain the advantages of nanoemulsions for the transdermal delivery of drugs. In transdermal delivery, the goal of dosage design is to maximize the flux through the skin into systemic circulation. A useful strategy for improving percutaneous flux is to improve the concentration of drug or choose an appropriate vehicle for the transdermal delivery. The nanoemulsions system should be a promising vehicle due to powerful ability to deliver drug through skins. With these approaches, the aim of this present study is to review the potential of nanoemulsion formulation for transdermal delivery of pure phytopharmaceuticals and poorly soluble drugs. Some nanoemulsions have however exhibited sufficiently high level of stability for them to be proposed as vehicle for drug delivery. Using the transdermal route eliminates the side effects, increases patient compliance, avoids first-pass metabolism, enhance bioavailability and maintains the plasma drug level for a longer period of time.Keywords: Transdernmal, poorly soluble drug, phytopharmaceuticals, nanoemulsion

Comparative standardization of a polyherbal Ayurvedic formulation <i>Talishadi Churna</i>

608-611India is a land mark for traditional system of medicine from the past few centuries. Most of the traditional systems of medicine are effective but only one major drawback is lack of standardization. So, there is a need to develop a standardization technique to mingle this system of medicine in the main stream of health sciences. Central Council for Research in Ayurveda and Siddha (CCRAS) has given preliminary guidelines for standardizing these conventional formulations. The present paper reports on standardization of Talishadi churna, an Ayurvedic formulation. Three marketed samples and in-house preparation were subjected to organoleptic study, physical characteristics, physiochemical screening and High Performance Thin Layer Chromatography (HPTLC) chromatogram. It was observed that all commercial samples and standard are similar in their organoleptic and qualitative chemical analysis but physical characteristic, fluorescence analysis and High Performance Thin Layer Chromatography (HPTLC) chromatogram of various formulations are not matching with each other, and it may be due to the raw material collection time, geographical variation, etc. Which can be further investigated for its pharmacological activity. This study provides ready reference for the selection of an appropriate formulation in the clinical practice and hence effective rational therapy, the overall theme of health sciences