1,173 research outputs found
3D Geometric Analysis of Tubular Objects based on Surface Normal Accumulation
This paper proposes a simple and efficient method for the reconstruction and
extraction of geometric parameters from 3D tubular objects. Our method
constructs an image that accumulates surface normal information, then peaks
within this image are located by tracking. Finally, the positions of these are
optimized to lie precisely on the tubular shape centerline. This method is very
versatile, and is able to process various input data types like full or partial
mesh acquired from 3D laser scans, 3D height map or discrete volumetric images.
The proposed algorithm is simple to implement, contains few parameters and can
be computed in linear time with respect to the number of surface faces. Since
the extracted tube centerline is accurate, we are able to decompose the tube
into rectilinear parts and torus-like parts. This is done with a new linear
time 3D torus detection algorithm, which follows the same principle of a
previous work on 2D arc circle recognition. Detailed experiments show the
versatility, accuracy and robustness of our new method.Comment: in 18th International Conference on Image Analysis and Processing,
Sep 2015, Genova, Italy. 201
Stimulus - response curves of a neuronal model for noisy subthreshold oscillations and related spike generation
We investigate the stimulus-dependent tuning properties of a noisy ionic
conductance model for intrinsic subthreshold oscillations in membrane potential
and associated spike generation. On depolarization by an applied current, the
model exhibits subthreshold oscillatory activity with occasional spike
generation when oscillations reach the spike threshold. We consider how the
amount of applied current, the noise intensity, variation of maximum
conductance values and scaling to different temperature ranges alter the
responses of the model with respect to voltage traces, interspike intervals and
their statistics and the mean spike frequency curves. We demonstrate that
subthreshold oscillatory neurons in the presence of noise can sensitively and
also selectively be tuned by stimulus-dependent variation of model parameters.Comment: 19 pages, 7 figure
The defining DNA methylation signature of Floating-Harbor Syndrome
Floating-Harbor syndrome (FHS) is an autosomal dominant genetic condition characterized by short stature, delayed osseous maturation, expressive language impairment, and unique facial dysmorphology. We previously identified mutations in the chromatin remodeling protein SRCAP (SNF2-related CBP Activator Protein) as the cause of FHS. SRCAP has multiple roles in chromatin and transcriptional regulation; however, specific epigenetic consequences of SRCAP mutations remain to be described. Using high resolution genome-wide DNA methylation analysis, we identified a unique and highly specific DNA methylation epi-signature in the peripheral blood of individuals with FHS. Both hyper and hypomethylated loci are distributed across the genome, preferentially occurring in CpG islands. Clonal bisulfite sequencing of two hypermethylated (FIGN and STPG2) and two hypomethylated (MYO1F and RASIP1) genes confirmed these findings. The identification of a unique methylation signature in FHS provides further insight into the biological function of SRCAP and provides a unique biomarker for this disorder
Spectrum and Variability of Mrk501 as observed by the CAT Imaging Telescope
The CAT Imaging Telescope has observed the BL Lac object Markarian 501
between March and August 1997. We report here on the variability over this time
including several large flares. We present also preliminary spectra for all
these data, for the low emission state, and for the largest flare.Comment: 4 pages, 4 figures, Late
Observation of the Crab Nebula Gamma-Ray Emission Above 220 Gev by the Cat Cherenkov Imaging Telescope
The CAT imaging telescope, recently built on the site of the former solar
plant Themis (French Pyrenees), observed gamma-rays from the Crab nebula from
October 1996 to March 1997. This steady source, often considered as the
standard candle of very-high-energy gamma-ray astronomy, is used as a test-beam
to probe the performances of the new telescope, particularly its energy
threshold (220 GeV at 20 degrees zenith angle) and the stability of its
response. Due to the fine-grain camera, an accurate analysis of the
longitudinal profiles of shower images is performed, yielding the source
position in two dimensions for each individual shower.Comment: 5 pages, 3 figures, Tex, contribution to 25th ICRC Durba
Detection of Vhe Gamma-Rays from MRK 501 with the Cat Imaging Telescope
The CAT imaging telescope on the site on the former solar plant Themis has
been observing gamma-rays from Mrk501 above 220 GeV in March and April 1997.
This source is shown to be highly variable and the light curve is presented.
The detected gamma-ray rate for the most intense flare is in excess of 10 per
minute.Comment: 5 pages, 4 figures, Tex, contribution to 25th ICRC Durba
Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development
In mammalian cells, the GW182 protein localizes to cytoplasmic bodies implicated in the regulation of messenger RNA (mRNA) stability, translation, and the RNA interference pathway. Many of these functions have also been assigned to analogous yeast cytoplasmic mRNA processing bodies. We have characterized the single Drosophila melanogaster homologue of the human GW182 protein family, which we have named Gawky (GW). Drosophila GW localizes to punctate, cytoplasmic foci in an RNA-dependent manner. Drosophila GW bodies (GWBs) appear to function analogously to human GWBs, as human GW182 colocalizes with GW when expressed in Drosophila cells. The RNA-induced silencing complex component Argonaute2 and orthologues of LSm4 and Xrn1 (Pacman) associated with 5′–3′ mRNA degradation localize to some GWBs. Reducing GW activity by mutation or antibody injection during syncytial embryo development leads to abnormal nuclear divisions, demonstrating an early requirement for GWB-mediated cytoplasmic mRNA regulation. This suggests that gw represents a previously unknown member of a small group of genes that need to be expressed zygotically during early embryo development
Estimating the inelasticity with the information theory approach
Using the information theory approach, in both its extensive and nonextensive
versions, we estimate the inelasticity parameter of hadronic reactions
together with its distribution and energy dependence from and
data. We find that the inelasticity remains essentially constant in energy
except for a variation around , as was originally expected.Comment: 14 pages, 8 figures. Misprints correcte
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