Potentiometric method for the quantification of carbonates in Calcidol® tablets. Stability Study

Se validó un método de análisis por valoración potenciométrica para realizar el estudio de estabilidad de las tabletas de Calcidol® , demostrándose que el mismo es específico, preciso, exacto y lineal. Se realizó el estudio de estabilidad del Calcidol® por el método de vida de estante observándose que las tabletas son estables durante 36 meses. Se demostró que la humedad y el calor afectan las características organolépticas de las mismas, no ocurriendo lo mismo con la luz.An analysis method by potentiometric tritation to carry out the stability study of Calcidol®’s tablets was validated, being demonstrated that it is specific, precise, exact and lineal. The stability study of Calcidol® was carried out by the "shelf life" method, being observed that the tablets are stable during 36 months. Humidity and heat affect the organoleptic characteristics of the tablets, not happening likewise with light.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Potentiometric method for the quantification of carbonates in Calcidol® tablets. Stability Study

Se validó un método de análisis por valoración potenciométrica para realizar el estudio de estabilidad de las tabletas de Calcidol® , demostrándose que el mismo es específico, preciso, exacto y lineal. Se realizó el estudio de estabilidad del Calcidol® por el método de vida de estante observándose que las tabletas son estables durante 36 meses. Se demostró que la humedad y el calor afectan las características organolépticas de las mismas, no ocurriendo lo mismo con la luz.An analysis method by potentiometric tritation to carry out the stability study of Calcidol®’s tablets was validated, being demonstrated that it is specific, precise, exact and lineal. The stability study of Calcidol® was carried out by the "shelf life" method, being observed that the tablets are stable during 36 months. Humidity and heat affect the organoleptic characteristics of the tablets, not happening likewise with light.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Technological development and stability study of chewable tablets of Calcium and Magnesium Citrate

El desarrollo de suplementos nutricionales en forma sólida (tabletas, cápsulas y granulados) a partir de fuentes naturales, resulta un área de constante interés en la investigación del farmacéutico, con la finalidad de lograr un sistema estable que cuente con actividad biológica. Con esta proyección se diseñó una formulación de citrato de calcio y magnesio en forma de tabletas masticables. Para ello se elaboraron diferentes ensayos tecnológicos resultando la formulación C la que rindiera mejores propiedades físicomecánicas y tecnológicas, así como una adecuada apariencia superficial; por lo que la seleccionamos como mejor variante tecnológica. De dicha formulación se derivaron granulados y tabletas con satisfactorias propiedades organolépticas, físico-mecánicas y tecnológicas. Los lotes de estabilidad fueron elaborados a escala piloto, demostrando la factibilidad del proceso de fabricación a esta escala. Las tabletas se envasaron en frascos plásticos de polietileno de baja densidad. La estabilidad química y microbiológica del producto terminado fue estudiada durante 36 meses y los resultados demostraron la buena estabilidad del mismo.The development of nutritional supplements in solid form (tablets, capsules and granulated) starting from natural sources, is an area of constant interest in the pharmacist's investigation, with the purpose of achieving a stable system that has biological activity. With this projection it was designed a formulation of calcium and magnesium mitrate in form of chewables tablets. For this different technological assays were elaborated, being the formulation C the one that surrendered better physical-mechanical and technological properties, as well as an appropriate superficial appearance, and then was selected as the better technological variant. From this formulation were derived granulated and tablets with satisfactory organoleptic, physical-mechanical and technological properties. The stability lots were elaborated to pilot scale, demonstrating the feasibility from the process of production at this scale. The tablets were packed in plastic bottles of low-density polyethylene. The chemical and microbiological stability of the finished product was studied during 36 months, and the results demonstrated the good stability of it.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Technological development and stability study of chewable tablets of Calcium and Magnesium Citrate

El desarrollo de suplementos nutricionales en forma sólida (tabletas, cápsulas y granulados) a partir de fuentes naturales, resulta un área de constante interés en la investigación del farmacéutico, con la finalidad de lograr un sistema estable que cuente con actividad biológica. Con esta proyección se diseñó una formulación de citrato de calcio y magnesio en forma de tabletas masticables. Para ello se elaboraron diferentes ensayos tecnológicos resultando la formulación C la que rindiera mejores propiedades físicomecánicas y tecnológicas, así como una adecuada apariencia superficial; por lo que la seleccionamos como mejor variante tecnológica. De dicha formulación se derivaron granulados y tabletas con satisfactorias propiedades organolépticas, físico-mecánicas y tecnológicas. Los lotes de estabilidad fueron elaborados a escala piloto, demostrando la factibilidad del proceso de fabricación a esta escala. Las tabletas se envasaron en frascos plásticos de polietileno de baja densidad. La estabilidad química y microbiológica del producto terminado fue estudiada durante 36 meses y los resultados demostraron la buena estabilidad del mismo.The development of nutritional supplements in solid form (tablets, capsules and granulated) starting from natural sources, is an area of constant interest in the pharmacist's investigation, with the purpose of achieving a stable system that has biological activity. With this projection it was designed a formulation of calcium and magnesium mitrate in form of chewables tablets. For this different technological assays were elaborated, being the formulation C the one that surrendered better physical-mechanical and technological properties, as well as an appropriate superficial appearance, and then was selected as the better technological variant. From this formulation were derived granulated and tablets with satisfactory organoleptic, physical-mechanical and technological properties. The stability lots were elaborated to pilot scale, demonstrating the feasibility from the process of production at this scale. The tablets were packed in plastic bottles of low-density polyethylene. The chemical and microbiological stability of the finished product was studied during 36 months, and the results demonstrated the good stability of it.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Anti-allodynic Effect of Mangiferin in Rats With Chronic Post-ischemia Pain: A Model of Complex Regional Pain Syndrome Type I

The present study reproduces chronic post-ischemia pain (CPIP), a model of complex regional pain syndrome type I (CRPS-I), in rats to examine the possible transient and long-term anti-allodynic effect of mangiferin (MG); as well as its potential beneficial interactions with some standard analgesic drugs and sympathetic-mediated vasoconstriction and vasodilator agents during the earlier stage of the pathology. A single dose of MG (50 and 100 mg/kg, p.o.) decreased mechanical allodynia 72 h post-ischemia-reperfusion (I/R). MG 100 mg/kg, i.p. (pre- vs. post-drug) increased von Frey thresholds in a yohimbine and naloxone-sensitive manner. Sub-effective doses of morphine, amitriptyline, prazosin, clonidine and a NO donor, SIN-1, in the presence of MG were found to be significantly anti-allodynic. A long-term anti-allodynic effect at 7 and 13 days post-I/R after repeated oral doses of MG (50 and 100 mg/kg) was also observed. Further, MG decreased spinal and muscle interleukin-1β concentration and restored muscle redox status. These results indicate that MG has a transient and long-term anti-allodynic effect in CPIP rats that appears to be at least partially attributable to the opioid and α2 adrenergic receptors. Additionally, its anti-inflammatory and antioxidant mechanisms could also be implicated in this effect. The association of MG with sub-effective doses of these drugs enhances the anti-allodynic effect; however, an isobolographic analysis should be performed to define a functional interaction between them. These findings suggest the possible clinical use of MG in the treatment of CRPS-I in both early sympathetically maintained pain and long-term sympathetically independent pain