A balanced complex chromosomal rearrangement (BCCR) in a family with reproductive failure

Balanced complex chromosomal rearrangements are very rare events in the human population. Translocations involving three or more chromosomes frequently lead to a severe reproductive impairment secondary to meiotic disturbance in males and to chromosomal imbalance in gametes of females. We report a new familial case of complex chromosome anomaly involving chromosomes 13, 14 and 22. Cytogenetic investigations showed a complex chromosomal chromosome rearrangement involving: (i) a Robertsonian translocation between chromosomes 13 and 14; and (ii) a reciprocal translocation between the long arms of chromosome 14 and the long arm of chromosome 22. The aetiology of the translocation was characterized by conventional fluorescence in‐situ hybridization (FISH) studies and routine R‐ and G‐banding (RTBG and GBTG) combined with α and β satellite centromeric FISH probes. Predicted configuration of the hexavalent at pachytene stage of meiosis was used to consider the modes of segregation; only two configurations resulted in a normal or balanced gamete karyotype. Reproductive management and genetic counselling are discusse

La substitution des images aux reliques, et ses limites, dans la diffusion de la virtus des saints (Espace FranÇais, fin XIIIe-XVe S.)

After an earlier study regarding the Italian corpus, this article continues for the French territory an ample research started from the pioneering views of André Vauchez regarding the substitution of images for relics in the employment of the virtus of saints away from their tomb. - The article does not deal with images of the Virgin. - On the chronological level, the French corpus fits these views much better than the Italian, since the phenomenon is only really observed there from the 14th cent. In addition, a series of new data confirm that various images became “focal points” of the cult of saints far away from their tomb. But, as for the Italian corpus, in the texts studied it is more often contact relics and tiny first-class relics that appear as efficacious carriers of virtus. The last pages of the article underline how much the presentation, in spite of everything, only gives a very partial picture of a particularly complex reality.SCOPUS: re.jinfo:eu-repo/semantics/publishe