2 research outputs found
Cystatin-C levels in healthy children and adolescents: Influence of age, gender, body mass index and blood pressure
Objectives: Cystatin-C is considered a more sensitive and specific
marker of kidney function than creatinine since it can diagnose patients
with earlier-stage of renal dysfunction. The aim of this study is to
determine the levels of Cystatin-C in healthy children and adolescents
as well as any correlations to age, gender, body-mass index (BMI) and
blood pressure (BP).
Design and methods: Cystatin-C was measured in 536 healthy Greek
children and adolescents (295 males and 241 females) using a
nephelometric immunoassay. Additionally, the age, body mass index and
blood pressure was recorded for each subject.
Results: Overall, the mean serum Cystatin-C level was 0.79 +/- 0.10
mg/L. Cystatin-C was found to be statistically significantly lower in
females than in males (p < 0.001) as well as in prepubertal children
compared to adolescents (p < 0.001). Higher values of Cystatin-C were
observed in subjects with increased BMI (p < 0.001). Neither systolic
nor diastolic blood pressure was found to significantly affect
Cystatin-C levels.
Conclusions: The levels of Cystatin-C were statistically significantly
higher in males, compared to age matched females and also positively
correlated with age and BMI. (C) 2015 The Canadian Society of Clinical
Chemists. Published by Elsevier Inc. All rights reserved