2 research outputs found
SICI during changing brain states: Differences in methodology can lead to different conclusions
Background: Short-latency intracortical inhibition (SICI) is extensively used to probe GABAergic inhibitory mechanisms in M1. Task-related changes in SICI are presumed to reflect changes in the central
excitability of GABAergic pathways. Usually, the level of SICI is evaluated using a single intensity of
conditioning stimulus so that inhibition can be compared in different brain states.
Objective: Here, we show that this approach may sometimes be inadequate since distinct conclusions
can be drawn if a different CS intensity is used.
Methods: We measured SICI using a range of CS intensities at rest and during a warned simple reaction
time task.
Conclusions: Our results show that SICI changes that occurred during the task could be either larger or
smaller than at rest depending on the intensity of the CS. These findings indicate that careful interpretation of results are needed when a single intensity of CS is used to measure task-related physiological
changes