Conformal SO(2,4) Transformations for the Helical AdS String Solution

By applying the conformal SO(2,4) transformations to the folded rotating string configuration with two spins given by a certain limit from the helical string solution in AdS_3 x S^1, we construct new string solutions whose energy-spin relations are characterized by the boost parameter. When two SO(2,4) transformations are performed with two boost parameters suitably chosen, the straight folded rotating string solution with one spin in AdS_3 is transformed in the long string limit into the long spiky string solution whose expression is given from the helical string solution in AdS_3 by making a limit that the modulus parameter becomes unity.Comment: 16 pages, LaTex, no figure

D1-brane in beta-Deformed Background

We study various configurations of rotating and wound D1-brane in AdS_5\times S^5 background and in its beta deformed version. We find giant magnon and spike solutions on the world-volume of D1-brane in AdS_5\times S^5 background. We also analyse the equations of motion of D1-brane in beta-deformed background. We show that in the limit of large electric flux on world-volume of D1-brane they reduce to the equations that describe collection of large number of fundamental strings. We also construct rotating and wound D1-brane solution that has two equal spins on S^5_\gamma.Comment: 26 pages, appendices and a reference added, to appear in JHE

Giant Magnons in AdS4 x CP3: Embeddings, Charges and a Hamiltonian

This paper studies giant magnons in CP3, which in all known cases are old solutions from S5 placed into two- and three-dimensional subspaces of CP3, namely CP1, RP2 and RP3. We clarify some points about these subspaces, and other potentially interesting three- and four-dimensional subspaces. After confirming that E-(J1-J4)/2 is a Hamiltonian for small fluctuations of the relevant 'vacuum' point particle solution, we use it to calculate the dispersion relation of each of the inequivalent giant magnons. We comment on the embedding of finite-J solutions, and use these to compare string solutions to giant magnons in the algebraic curve.Comment: 17 pages (plus appendices) and 1 figure. v2 has new discussion of placing finite-J giant magnons into CP^3, adds many references, and corrects a few typo

Ancient pigs reveal a near-complete genomic turnover following their introduction to Europe

Archaeological evidence indicates that pig domestication had begun by ∼10,500 y before the present (BP) in the Near East, and mitochondrial DNA (mtDNA) suggests that pigs arrived in Europe alongside farmers ∼8,500 y BP. A few thousand years after the introduction of Near Eastern pigs into Europe, however, their characteristic mtDNA signature disappeared and was replaced by haplotypes associated with European wild boars. This turnover could be accounted for by substantial gene flow from local European wild boars, although it is also possible that European wild boars were domesticated independently without any genetic contribution from the Near East. To test these hypotheses, we obtained mtDNA sequences from 2,099 modern and ancient pig samples and 63 nuclear ancient genomes from Near Eastern and European pigs. Our analyses revealed that European domestic pigs dating from 7,100 to 6,000 y BP possessed both Near Eastern and European nuclear ancestry, while later pigs possessed no more than 4% Near Eastern ancestry, indicating that gene flow from European wild boars resulted in a near-complete disappearance of Near East ancestry. In addition, we demonstrate that a variant at a locus encoding black coat color likely originated in the Near East and persisted in European pigs. Altogether, our results indicate that while pigs were not independently domesticated in Europe, the vast majority of human-mediated selection over the past 5,000 y focused on the genomic fraction derived from the European wild boars, and not on the fraction that was selected by early Neolithic farmers over the first 2,500 y of the domestication process

Adipokines and metabolic regulators in human and experimental pulmonary arterial hypertension

Pulmonary hypertension (PH) is associated with meta-inflammation related to obesity but the role of adipose tissue in PH pathogenesis is unknown. We hypothesized that adipose tissue-derived metabolic regulators are altered in human and experimental PH. We measured circulating levels of fatty acid binding protein 4 (FABP-4), fibroblast growth factor-21 (FGF-21), adiponectin, and the mRNA levels of FABP-4, FGF-21, and peroxisome proliferator-activated receptor γ (PPARγ) in lung tissue of patients with idiopathic PH and healthy controls. We also evaluated lung and adipose tissue expression of these mediators in the three most commonly used experimental rodent models of pulmonary hypertension. Circulating levels of FABP-4, FGF-21, and adiponectin were significantly elevated in PH patients compared to controls and the mRNA levels of these regulators and PPARγ were also significantly increased in human PH lungs and in the lungs of rats with experimental PH compared to controls. These findings were coupled with increased levels of adipose tissue mRNA of genes related to glucose uptake, glycolysis, tricarboxylic acid cycle, and fatty acid oxidation in experimental PH. Our results support that metabolic alterations in human PH are recapitulated in rodent models of the disease and suggest that adipose tissue may contribute to PH pathogenesis. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

Cord blood fatty acid-binding protein-4 levels are upregulated at both ends of the birthweight spectrum

Aim: Fatty acid-binding protein-4 (FABP4) is an adipokine associated with obesity and signs of the metabolic syndrome. We aimed to investigate at birth in term neonates with normal and abnormal intrauterine growth concentrations of FABP4 and associate them with various perinatal parameters. Methods: Serum cord blood FABP4 levels were prospectively determined by ELISA in 80 singleton term appropriate-for-gestational-age (AGA), intrauterine growth-restricted (IUGR) and large-for-gestational-age (LGA) neonates. Results: Compared to the AGA group, cord blood FABP4 levels were increased in the IUGR and LGA groups. Additionally, they were higher in early-term than full-term neonates. A significant U-shaped correlation was recorded between serum FABP4 levels and birthweight. A significant negative correlation between cord blood FABP4 and gestational age in the whole study population was noted. Conclusion: Cord blood FABP4 levels were significantly higher at the extremes of foetal growth at term and negatively correlated with gestational age, being increased in early-term versus full-term neonates. Further longitudinal studies with larger sample sizes are required to elucidate FABP4 implication in foetal growth and its association with future adverse cardiometabolic outcomes in the offspring. ©2019 Foundation Acta Pædiatrica. Published by John Wiley & Sons Lt