6 research outputs found
Elevated soluble urokinase receptor values in CSF, age and bacterial meningitis infection are independent and additive risk factors of fatal outcome
The aim of the present study was to evaluate the potential role of
cerebrospinal fluid soluble urokinase receptor (suPAR) level, infection
and age as risk factors for fatal outcome in patients suspected of
having meningitis and/or bacteraemia on admission to hospital. A total
of 545 cerebrospinal fluid samples from patients with clinically
suspected meningitis were sent to the Hellenic National Meningitis
Reference Laboratory. Ten of 545 (1.83%) patients died. Analysis by
receiver operating characteristics (ROC) curve revealed that both suPAR
and age were significant for prediction of fatal outcome. Patients with
levels of suPAR above the cut-off values and age a parts per thousand
yen51 years, or patients in which either or were detected were
categorized as high risk patients. The combination of the above three
predictors (suPAR, age and infectious agent) in a logistic regression
model with outcome of infection as the dependent variable yielded an
overall odds ratio (OR = 85.7, 95% CI 10.6-690.2) with both sensitivity
and specificity being equal to the value of 0.9. In conclusion, suPAR,
age and type of infection have an additive effect in predicting
mortality among patients suspected of meningitis