Traitement des cancers du rein dans la maladie de Von Hippel-Lindau (étude rétrospective de 18 cas)

LYON1-BU Santé (693882101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Genitourinary injuries following traffic accidents: analysis of a registry of 162,690 victims

BACKGROUNDTraffic accidents are the most frequent cause of genitourinary injuries (GUI). Kidney injuries after trauma have been well described. However, there exists a paucity of data on other traumatic GUI after traffic accidents. The objective of this study was to analyze the frequency and type of all GUI, by user category, after traffic accidents.METHODS: Patient cases were extracted from the trauma registry of the French department of Rhone from 1996 to 2013. We assessed the urogenital injuries presented by each of road user’s categories. Severity injuries were coded with the Abbreviated Injury Scale and the Injury Severity Score. Kidney trauma was mapped with the classification of the American Association for the Surgery of Trauma. Multivariate prediction models were used for analysis of data.RESULTS: Of 162,690 victims, 963 presented with GUI (0.59%). 47% were motorcyclists, 22% were in a car, 18% on bicycles, and 9% were pedestrians. The most common organ injury was kidney (41%) followed by testicular (23%). Among the 208 motorists with a GUI, kidney (70%), bladder (10%), and adrenal gland (9%) were the most frequent lesions. Among the 453 motorcyclist victims with GUI, kidney (35%) and testicular (38%) traumas were the most frequent and 62% of injuries involved external genitalia. There were 175 cyclists with GUI, 70% of injuries involved external genitalia; penile traumas (23%) were the most frequent. In total, there were 395 kidney injuries, most being low grade. According to the American Association for the Surgery of Trauma kidney injuries were grade I, 59%; grade II, 11%; grade III, 16%; grade IV, 9%; grade V, 3%; and indeterminate, 2%.CONCLUSION: GUI is an infrequent trauma after traffic accidents, with kidneys being the most commonly injured. Physicians must maintain a high awareness for external genitalia injuries in motorcyclists and cyclists.LEVEL OF EVIDENCE: Prognostic and epidemiologic study, level III.Les accidents de la route sont la cause la plus fréquente de blessures génito-urinaires, représentant 48 % à 66 % de tout le trauma de reins (1-3). Néanmoins, l'épidémiologie de trauma de système génito-urinaire après des accidents de la route n'a pas été bien étudiée. Seulement quelques études ont rapporté l'épidémiologie de blessures génito-urinaires dans une grande base de données

Determining the outcomes of urethral construction in phalloplasty

International audienc

Technique of Injection of Hyaluronic Acid as a Prostatic Spacer and Fiducials Before Hypofractionated External Beam Radiotherapy for Prostate Cancer

International audienc

Modèle de prédiction de la force à rupture du fémur métastatique : caractérisation des propriétés mécaniques de tumeurs

Forum CLARA, Lyon, France, 04-/04/2023 - 05/04/2023Les métastases osseuses sont associées à de sévères complications, telles que les fractures osseuses. Des scores cliniques, comme le score Mirels, permettent d'estimer le risque de fracture mais ils manquent de précision. Les modèles éléments finis patient-spécifiques sont un outil prometteur pour évaluer la force à rupture du fémur. Cependant, le manque de connaissances des propriétés mécaniques des métastases osseuses peut limiter la précision de ces modèles. L'objectif de cette étude était donc de caractériser les propriétés mécaniques de différents types de tumeurs qui métastasent fréquemment à l'os, afin d'évaluer l'influence de ces propriétés sur la prédiction de la force à rupture du fémur métastatique. Dans un premier temps, des prélèvements de tumeurs humaines (sein, rein et thyroïde) ont été obtenus après chirurgie et divisés en deux échantillons. Un échantillon a été utilisé pour une analyse histologique (type de cancer, quantité de fibrose...). Sur le deuxième échantillon, des essais d'indentation - fluage ont été effectués par microcopie à force atomique, pour déterminer respectivement la rigidité (module élastique) et la viscosité (fraction élastique). Les tumeurs de sein, constituées de fibrose, voient leur rigidité augmenter. La rigidité des tumeurs de rein et thyroïde varie différemment selon la quantité de fibrose. De plus, la fraction élastique de la thyroïde tend à diminuer dans le tissu tumoral, suggérant une augmentation de la viscosité. Ces résultats montrent la variabilité des propriétés mécaniques du tissu tumoral selon la nature du cancer et la structure et composition de la tumeur. Dans un second temps, des prélèvements de métastases osseuses seront caractérisées sur le plan mécanique. Ces propriétés mécaniques seront ensuite incorporées dans les modèles patient-spécifiques, afin d'évaluer la nécessité d'utiliser des propriétés personnalisées pour la métastase

Mechanical properties and structure of tumour microenvironment in breast, kidney, and thyroid cancer

5th International Cancer Symposium, Lyon, France, 02-/11/2022 - 04/11/2022The aim of this study was to characterize the viscoelastic properties of different types of human tumor tissue that frequently metastasize to the bone and to correlate them with tissue structure

Mechanical properties of breast, kidney, and thyroid tumours measured by AFM: relationship with tissue structure

The mechanical properties of the extracellular matrix are essential for regulating cancer cell behaviour, but how they change depending on tumour type remains unclear. The aim of the current study was to determine how the mechanical properties of tumours that frequently metastasize to bones were affected depending on histological type. Human breast, kidney, and thyroid specimens containing tumour and normal tissue were collected during surgery. The elastic modulus and elastic fraction of each sample were characterised using atomic force microscopy and compared with histopathological markers. We observed that tumour mechanical properties were differentially affected depending on organ and histological type. Indeed, clear cell renal carcinoma and poorly differentiated thyroid carcinoma displayed a decrease in the elastic modulus compared to their normal counterpart, while breast tumours, papillary renal carcinoma and fibrotic thyroid tumours displayed an increase in the elastic modulus. Elastic fraction decreased only for thyroid tumour tissue, indicating an increase in viscosity. These findings suggest a unique mechanical profile associated with each subtype of cancer. Therefore, viscosity could be a discriminator between tumour and normal thyroid tissue, while elasticity could be a discriminator between the subtypes of breast, kidney and thyroid cancers