9 research outputs found
Distribution of responses to PHA and ESAT6/CFP10 ELISPOT assays in HIV patients, by CD4 cell count (boxplot showing median, IQR and range) (n = 285).
<p>1A: Distribution of responses to PHA. 1B: Distribution of responses to ESAT6/CFP10.</p
Analysis of the determinants of positive response to the ESAT6/CFP10 ELISPOT assay and to the TST (n = 247).
<p>Analysis of the determinants of positive response to the ESAT6/CFP10 ELISPOT assay and to the TST (n = 247).</p
Characteristics of patients included in the cohort, with a detail of those responding and those not responding to ELISPOT PHA positive control.
*<p><i>p</i> value for difference between PHA<100 and PHA≥100 SFC/10<sup>6</sup>.</p
Epidemiological and clinical characteristics of HIV-1 eligible volunteers.
<p>Data are median (interquartile range) values when indicated.</p>*<p>ALAT: alanine transferase.</p
IFN-γ secreting cells (ISC) with the sum of peptides (A), the single pool (B) per 10<sup>6</sup> PBMCs to the HIV+ART<b>–</b> group and HIV+ART+ group at the baseline timeline versus post vaccination.
*<p>Mann Whitney test.</p
IFN-γ secreting cells (ISC) with the summed peptide pools (A, C), the single pool (B, D) per 10<sup>6</sup> PBMCs for the HIV+ART<b>–</b> and HIV+ART+ groups after the first dose and second dose of MVA85A.
<p>Mann Whitney test was used.</p
CD4+ T cell responses and HIV RNA load measurements after MVA85A vaccination.
<p>(A) CD4+ T cell count in 12 HIV+ART−, volunteers (group 1) and (B) in 12 HIV+ART+ volunteers (group 2). (C) HIV RNA load in 12 HIV+ART<b>–</b> volunteers (group 1) and (D) in 12 HIV+ART+ volunteers (group 2). Median values shown in red.</p
Immunogenicity of MVA85A – HIV+ART– group (A, B, C) compared to HIV+ART+ group (D, E, F).
<p>Measured by ex vivo ELISpot assay in the sum of pool of antigen 85A peptides <b>(A, D)</b>, the single pool of 66 peptides antigen 85A <b>(B, E)</b> and in the recombinant antigen 85A <b>(C, F)</b>. The figures also compare the responses after the first (arrow) and second vaccination (arrow).</p
Reasons for exclusion from recruitment into the trial.
*<p>Some subjects were excluded for more than one reason.</p