Images of CL from DIR scans (A, C, E) and PSIR scans (B, D, F) from three different patients.

<p>(a), two IC lesions (arrows) are observed on DIR (A) and confirmed on PSIR (B) images. (b), two IC lesions (arrows) are detected on DIR (C) and confirmed on PSIR (D) images. However, an additional ‘linear’ IC lesion can be observed on PSIR (arrow head); this lesion was not identified at the first analysis of DIR scan, but its signal intensity was re-evaluated as an IC lesion after PSIR analysis. (c), a LC (mixed) lesion is observed on PSIR (F), but not on DIR scan given the weak signal.</p

Frequencies of new MRI CLs over 1 and 2 years observed and predicted under the Poisson, the NB, the ZIP and the ZINB models.

<p>Frequencies of new MRI CLs over 1 and 2 years observed and predicted under the Poisson, the NB, the ZIP and the ZINB models.</p

Number of patients per arm for an active controlled trial with the number of new cortical lesions counted over 1 and 2 years.

<p>Number of patients per arm for an active controlled trial with the number of new cortical lesions counted over 1 and 2 years.</p

Areas of cortical thickening in PD-MCI versus PD-CNT.

*<p> = Cortical thickness comparison significant after AlphaSim threshold correction.</p><p>Remaining areas were not significant after correction and are reported as trend.</p

Histograms of the observed and predicted distribution of CLs over 1 and 2 years.

<p>Histograms of the distribution of the number of cortical lesions counted over 1 and 2 years in the non-treated and in the 3 treated groups, and their probability distribution implied by the Poisson (blue lines), the zero-inflated Poisson (yellow lines), the Negative Binomial (red lines) and the zero-inflated Negative Binomial (green lines) models. The Akaike Information Criterion (AIC) is calculated on the whole group of patients adjusting for treatment arm. Lower values of the AIC indicate better fits.</p

Regions of significant cortical thickness changes in PD-MCI vs. PD-CNT.

<p>Panel a) PD-MCI atrophy; b) PD-MCI hypertrophy. Statistical threshold used T = 1.69, p<0.05.</p

Subcortical volume comparisons between PD and HC.

*<p> = Comparisons significant after Bonferroni correction.</p><p>Remaining areas were not significant after correction and are reported as trend.</p

Demographic and clinical characteristics of PD subgroups.

<p>Demographic and clinical characteristics of PD subgroups.</p

Supplementary Material 2, MSJ779951_supplementary_material_2 – Peripheral imbalanced TFH/TFR ratio correlates with intrathecal IgG synthesis in multiple sclerosis at clinical onset

<p>Supplementary Material 2, MSJ779951_supplementary_material_2 for Peripheral imbalanced TFH/TFR ratio correlates with intrathecal IgG synthesis in multiple sclerosis at clinical onset by Marco Puthenparampil, Antonio Zito, Giorgia Pantano, Lisa Federle, Erica Stropparo, Silvia Miante, Giustina De Silvestro, Mario Plebani and Paolo Gallo in Multiple Sclerosis Journal</p

Supplementary Material 3, MSJ779951_supplementary_material_3 – Peripheral imbalanced TFH/TFR ratio correlates with intrathecal IgG synthesis in multiple sclerosis at clinical onset

<p>Supplementary Material 3, MSJ779951_supplementary_material_3 for Peripheral imbalanced TFH/TFR ratio correlates with intrathecal IgG synthesis in multiple sclerosis at clinical onset by Marco Puthenparampil, Antonio Zito, Giorgia Pantano, Lisa Federle, Erica Stropparo, Silvia Miante, Giustina De Silvestro, Mario Plebani and Paolo Gallo in Multiple Sclerosis Journal</p