sj-docx-1-msj-10.1177_13524585241231155 – Supplemental material for 2.5-Year changes of connectivity dynamism are relevant for physical and cognitive deterioration in multiple sclerosis

Supplemental material, sj-docx-1-msj-10.1177_13524585241231155 for 2.5-Year changes of connectivity dynamism are relevant for physical and cognitive deterioration in multiple sclerosis by Maria A Rocca, Giulia D’Amore, Paola Valsasina, Nicolò Tedone, Alessandro Meani and Massimo Filippi in Multiple Sclerosis Journal</p

Vertex-by-vertex analysis: regions of significantly thinner cortex in patients with amyotrophic lateral sclerosis compared with healthy controls represented on an averaged brain map.

<p>Color bar represents t values (p<0.05, uncorrected for multiple comparisons).</p

MSJ778008_supplementary_appendix_2 – Supplemental material for Cross-modal plasticity among sensory networks in neuromyelitis optica spectrum disorders

<p>Supplemental material, MSJ778008_supplementary_appendix_2 for Cross-modal plasticity among sensory networks in neuromyelitis optica spectrum disorders by Maria Assunta Rocca, Filippo Savoldi, Paola Valsasina, Marta Radaelli, Paolo Preziosa, Giancarlo Comi, Andrea Falini and Massimo Filippi in Multiple Sclerosis Journal</p

Left hemisphere: regions with different mean cortical thickness in patients with amyotrophic lateral sclerosis compared with healthy controls.

<p>Values are mean thickness ± standard deviation (mm) or percent difference.</p>*<p>p values refer to multivariate liner models, adjusting for subject's age (False-Discovery rate corrected).</p

Cortical regions showing a significant cortical thinning in patients with amyotrophic lateral sclerosis compared with healthy controls overlaid on the lateral (top row) and medial (bottom row) views of the left and right hemispheres.

<p>Regions are color-coded according to the percent difference of cortical thickness between the two groups.</p

Clusters and cluster-centroids identified in the right (R) primary auditory cortex (PAC) in healthy controls (blue) and Leber's hereditary optic neuropathy (LHON) patients (red).

<p>The silhouette analysis identified two clusters in healthy controls and four clusters in LHON patients. The cluster-centroid profile analysis of the R PAC of LHON patients showed a structural connectivity with the frontal pole, the pallidum, and the supramarginal gyrus, which was not detected in controls. X-axis reports brain areas classified according to the Harvard-Oxford cortical and subcortical atlas.</p

Right hemisphere: regions with different mean cortical thickness in patients with amyotrophic lateral sclerosis compared with healthy controls.

<p>Values are mean thickness ± standard deviation (mm) or percent difference.</p>*<p>p values refer to multivariate liner models, adjusting for subject's age (False-Discovery rate corrected).</p

Sensorimotor, cognitive-frontal and cognitive-temporal mask mean cortical thickness in patients with amyotrophic lateral sclerosis compared with healthy controls.

<p>Values are mean thickness ± standard deviation (mm) or percent difference.</p>*<p>p values refer to multivariate liner models, adjusting for subject's age (False-Discovery rate corrected).</p><p>Abbreviations: ALS = amyotrophic lateral sclerosis; C index = Concordance index.</p

Demographic and clinical data from healthy controls and patients with amyotrophic lateral sclerosis.

<p>Numbers are mean ± standard deviation (range) or number. °Disease progression rate = (48-ALSFRS-r score)/time from symptom onset.</p>*<p>Mann-Whitney-U-test or Fisher exact test as appropriate (see text fro further details). Abbreviations: ALS = amyotrophic lateral sclerosis; ALSFRS-r = ALS Functional Rating scale-revised.</p

MSJ778008_supplementary_appendix – Supplemental material for Cross-modal plasticity among sensory networks in neuromyelitis optica spectrum disorders

<p>Supplemental material, MSJ778008_supplementary_appendix for Cross-modal plasticity among sensory networks in neuromyelitis optica spectrum disorders by Maria Assunta Rocca, Filippo Savoldi, Paola Valsasina, Marta Radaelli, Paolo Preziosa, Giancarlo Comi, Andrea Falini and Massimo Filippi in Multiple Sclerosis Journal</p