28 research outputs found
Natural AChE inhibitors from plants and their contribution to Alzheimer´s disease therapy
As acetylcholinesterase (AChE) inhibitors are an important therapeutic strategy in Alzheimer's disease, efforts are being made in search of new molecules with anti-AChE activity. The fact that naturally-occurring compounds from plants are considered to be a potential source of new inhibitors has led to the discovery of an important number of secondary metabolites and plant extracts with the ability of inhibiting the enzyme AChE, which, according to the cholinergic hypothesis, increases the levels of the neurotransmitter acetylcholine in the brain, thus improving cholinergic functions in patients with Alzheimer's disease and alleviating the symptoms of this neurological disorder. This review summarizes a total of 128 studies which correspond to the most relevant research work published during 2006-2012 (1st semester) on plant-derived compounds, plant extracts and essential oils found to elicit AChE inhibition.Fil: Murray, Ana Paula. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico BahĂa Blanca. Instituto de QuĂmica del Sur; Argentina. Universidad Nacional del Sur; ArgentinaFil: Faraoni, MarĂa BelĂ©n. Universidad Nacional del Sur. Departamento de QuĂmica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico BahĂa Blanca. Instituto de QuĂmica del Sur; ArgentinaFil: Castro, Maria Julia. Universidad Nacional del Sur. Departamento de QuĂmica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico BahĂa Blanca. Instituto de QuĂmica del Sur; ArgentinaFil: Alza, Natalia Paola. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico BahĂa Blanca. Instituto de QuĂmica del Sur; Argentina. Universidad Nacional del Sur; ArgentinaFil: Cavallaro, Valeria. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico BahĂa Blanca. Instituto de QuĂmica del Sur; Argentina. Universidad Nacional del Sur; Argentin
Particle detectors, geodesic motion, and the equivalence principle
It is shown that quantum particle detectors are not reliable probes of
spacetime structure. In particular, they fail to distinguish between inertial
and non-inertial motion in a general spacetime. To prove this, we consider
detectors undergoing circular motion in an arbitrary static spherically
symmetric spacetime, and give a necessary and sufficient condition for the
response function to vanish when the field is in the static vacuum state. By
examining two particular cases, we show that there is no relation, in general,
between the vanishing of the response function and the fact that the detector
motion is, or is not, geodesic. In static asymptotically flat spacetimes,
however, all rotating detectors are excited in the static vacuum. Thus, in this
particular case the static vacuum appears to be associated with a non-rotating
frame. The implications of these results for the equivalence principle are
considered. In particular, we discuss how to properly formulate the principle
for particle detectors, and show that it is satisfied.Comment: 14 pages. Revised version, with corrections; added two references.
Accepted for publication in Class. Quantum Gra