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Chiral Solvent Discovery: Exploring Chiral Eutectic Mixtures and Deep Eutectic Solvents
Deep eutectic solvents (DES) are mixtures that have a
melting point
much lower than any of the components. Because the properties of DES,
such as chiral discrimination, can be controlled through choice of
components, DES have potential as solvents in many chemical and industrial
applications. However, the large number of potential components makes
high throughput methods of DES discovery critical for their development.
In this study, mixtures of small quantities of hydrogen bond acceptors
(HBAs) and chiral hydrogen bond donors (HBDs) were mixed at 55 °C
and cooled to 20 °C to screen for potential liquid formation.
Variable molar ratios of 10 HBAs were mixed with 93 chiral HBDs to
measure a total of 1250 mixtures, and 356 mixtures were liquid at
20 °C. All of the results including mixtures that did not form
liquids are provided in a publicly available database. Several of
the mixtures were prepared in larger quantities to characterize their
physical properties, including melting points, densities, and viscosities.
The results of this study can be used to guide the discovery and development
of new chiral solvents, such as DES and eutectic mixtures