Cytotoxic and larvicidal activities of Stemona alkaloids from the aerial parts and roots of Stemona curtisii Hook.f.

2020, 2020 Informa UK Limited, trading as Taylor & Francis Group. A new Stemona alkaloid glycoside derivative, 6-hydroxy-5,6-seco-stemocurtisinoside (4), was isolated from the ethanolic extract of the aerial parts of Stemona curtisii Hook.f., together with stemocurtisine (1), (11Z)-1\u27,2\u27-didehydrostemofoline (2) and 6-hydroxy-5,6-seco-stemocurtisine (3). Whereas, stemocurtisine (1), stemocurtisinol (5) and oxyprotostemonine (6) were isolated from the roots. Their structures were elucidated using 1D and 2D NMR spectroscopy as well as MS experiments. The extract and the pure isolated compounds were evaluated for their cytotoxicities and their larvicidal activities against the dengue vector, Aedes aegypti. The alkaloid 2 showed the strongest larvicidal activity with a LC50 value of 2.44 µM. While the alkaloid 3 exhibited cytotoxicity against MCF-7 and KB cells (IC50 values of 62.52 and 18.82 µM, respectively) and showed no significant cytotoxicity against Vero cells. Additionally, quantitative analysis of the most active compounds; 2 and 3 in the crude extracts was also performed by HPLC

Chemical diversity and anti-acne inducing bacterial potentials of essential oils from selected Elsholtzia species

Essential oils from the aerial parts of four Elsholtzia species; Elsholtzia stachyodes, Elsholtzia communis, Elsholtzia griffithii and Elsholtzia beddomei were obtained by steam distillation and their chemical components were analysed by gas chromatography-mass spectrometry (GC-MS). Principle Component Analysis was used to identify the chemical variations in the essential oils from these plants, which could be categorised into two groups according to their main chemical components which are acylfuran derivatives and oxygenated monoterpenes. Additionally, the anti-acne inducing bacterial activity against Staphylococcus aureus and Staphylococcus epidermidis were evaluated. The oil from E. stachyodes was the most efficacious against the growth of S. aureus and S. epidermidis having MIC values of 0.78 and 1.56 μL/mL, respectively, and exhibited five times more effective than erythromycin (standard antibiotic)

Chemical diversity and anti-acne inducing bacterial potentials of essential oils from selected <i>Elsholtzia</i> species

<p>Essential oils from the aerial parts of four <i>Elsholtzia</i> species; <i>Elsholtzia stachyodes</i>, <i>Elsholtzia communis</i>, <i>Elsholtzia griffithii</i> and <i>Elsholtzia beddomei</i> were obtained by steam distillation and their chemical components were analysed by gas chromatography-mass spectrometry (GC-MS). Principle Component Analysis was used to identify the chemical variations in the essential oils from these plants, which could be categorised into two groups according to their main chemical components which are acylfuran derivatives and oxygenated monoterpenes. Additionally, the anti-acne inducing bacterial activity against <i>Staphylococcus aureus</i> and <i>Staphylococcus epidermidis</i> were evaluated. The oil from <i>E. stachyodes</i> was the most efficacious against the growth of <i>S. aureus</i> and <i>S. epidermidis</i> having MIC values of 0.78 and 1.56 μL/mL, respectively, and exhibited five times more effective than erythromycin (standard antibiotic).</p