19 research outputs found
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OPTIMIZATION OF EXTRACELLULAR SMALL RNA ISOLATION METHODS FOR TRANSCRIPTOMIC PROFILING OF URINARY EXTRACELLULAR VESICLES IN PREGNANCY
The role of insulin-like growth factor 2 receptor-mediated homeobox gene expression in human placental apoptosis, and its implications in idiopathic fetal growth restriction
The concentrations of Cr (III) and Cr (VI) were determined in the upper 500 m of the Sargasso Sea at different times of the year. Total Cr concentrations ranged between 2.5 and 4.5 nM, and the predominant species of Cr was the thermodynamically favoured Cr (VI). Cr (III) concentrations were greatest during periods of high biological activity, as indicated by strong correlations between the ratio of Cr (III):Cr (VI) and both bacterial biomass and primary productivity. Whilst the oxidation state varied substantially over the seasonal cycle, the upper water column inventory of Cr was relatively constant. The long residence time of Cr in the surface Sargasso Sea estimated with respect to atmospheric inputs (1410–2240 years) is indicative of the largely conservative behaviour of this element. Deep particle fluxes of Cr are similar or somewhat greater than atmospheric inputs, and this downward flux of Cr is well correlated with organic carbon fluxes from the upper Sargasso Sea. The long residence time coupled with the seasonal changes in oxidation state of Cr implies rapid seasonal recycling of Cr between redox states, with only slow removal via particles to the deep ocean at this site. <br/
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Humoral immune response to SARS-CoV-2 in pregnant and nonpregnant women following infection
BackgroundImmune changes that occur during pregnancy may place pregnant women at an increased risk for severe disease following viral infections like SARS-CoV-2. Whether these immunologic changes modify the immune response to SARS-CoV-2 infection during pregnancy is not well understood.ObjectiveThis study aimed to compare the humoral immune response to SARS-CoV-2 infection in pregnant and nonpregnant women. The immune response following vaccination for SARS-CoV-2 was also explored.Study designIn this cohort study, 24 serum samples from 20 patients infected with SARS-CoV-2 during pregnancy were matched by number of days after a positive test with 46 samples from 40 nonpregnant women of reproductive age. Samples from 9 patients who were vaccinated during pregnancy were also examined. Immunoglobulin G and immunoglobulin M levels were measured. Trends in the log antibody levels over time and mean antibody levels were assessed using generalized estimating equations.ResultsThe median number of days from first positive test to sampling was 6.5 in the pregnant group (range, 3-97) and 6.0 among nonpregnant participants (range, 2-97). No significant differences in demographic or sampling characteristics were noted between the groups. No differences in immunoglobulin G or immunoglobulin M levels over time or mean antibody levels were noted among pregnant and nonpregnant participants following SARS-CoV-2 infection for any of the SARS-CoV-2 antigen targets examined (spike, spike receptor-binding domain, spike N-terminal domain, and nucleocapsid). Participants who were vaccinated during pregnancy had higher immunoglobulin G levels than pregnant patients who tested positive for all SARS-CoV-2 targets except nucleocapsid antibodies (all P<.001) and had lower immunoglobulin M spike (P<.05) and receptor-binding domain (P<.01) antibody levels.ConclusionThis study suggests that the humoral response following SARS-CoV-2 infection does not seem to differ between pregnant women and their nonpregnant counterparts. These findings should reassure patients and healthcare providers that pregnant patients seem to mount a nondifferential immune response to SARS-CoV-2